| Project/Area Number |
24659652
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kyushu University |
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Principal Investigator |
NAKAMIZO AKIRA 九州大学, 医学(系)研究科(研究院), 講師 (80529800)
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| Co-Investigator(Kenkyū-buntansha) |
HATA Nobuhiro 独立行政法人国立病院機構九州医療センター, 臨床研究センター (10596034)
AMANO Toshiyuki 九州大学, 大学院医学研究院脳神経外科, 助教 (70448413)
KIKKAWA Yuichiro 九州大学, 大学院医学研究院脳神経外科, 助教 (80423515)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 間葉系幹細胞 / 脳動脈瘤 / マクロファージ / micro RNA |
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| Research Abstract |
The macrophage is largely responsible for the development of cerebral aneurysms. We showed that macrophages secreted high level of matrix metalloproteinase (MMP)-9 via the intracellular and extracellular expression of microRNA-21. Moreover, we revealed that conditioned medium of mesenchymal stem cell suppressed the secretion of MMP-9 from macrophages. Furthermore, we showed that mesenchymal stem cells secreted a wide variety of microRNAs including microRNA-145 that inhibited the secretion of MMPs. This indicated that mesenchymal stem cell-derived exosomal microRNA-145 was introduced into macrophage, resulting in the suppression of MMP-9 secretion.
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