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The dynamics of DNA damage response in glioblastoma-Toward the development of new therapy-

Research Project

Project/Area Number 24659653
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionKyushu University

Principal Investigator

YOSHIMOTO KOJI  九州大学, 大学病院, 講師 (70444784)

Co-Investigator(Kenkyū-buntansha) HATA Nobuhiro  九州大学, 大学病院, 助教 (10596034)
AMANO Toshiyuki  九州大学, 大学病院, 助教 (70448413)
NAKAMIZO Akira  九州大学, 医学研究院, 講師 (80529800)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords脳腫瘍 / 膠芽腫 / DNA損傷応答
Research Abstract

Cellular DNA is exposed to various kinds of DNA damage inducers. To combat these DNA damage, normal cells have intrinsic DNA damage response (DDR) system to protect the cell from endogenous and exogenous DNA damage inducer. In this study , we demonstrated that ATM/Chk2 pathway is inactivated in glioblastoma tissue, indicating that ATM/Chk2 pathway functions as tumor suppressor in the process of gliomagenesis.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2013

All Presentation (2 results)

  • [Presentation] グリオーマにおけるATM/Chk2シグナル伝達系変異の意義2013

    • Author(s)
      吉本幸司、村田秀樹、波多江龍亮、溝口昌弘
    • Organizer
      日本脳神経外科学会第72回学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2013-10-17
    • Related Report
      2013 Final Research Report
  • [Presentation] グリオーマにおけるATM/Chk2 シグナル伝達系変異の意義2013

    • Author(s)
      吉本幸司、村田秀樹、波多江龍亮、溝口昌弘
    • Organizer
      日本脳神経外科学会第72回学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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