Immunotherapy targeting brain tumor stem cell antigen and niche
| Project/Area Number |
24659657
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Keio University |
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Principal Investigator |
TODA Masahiro 慶應義塾大学, 医学部, 准教授 (20217508)
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| Co-Investigator(Renkei-kenkyūsha) |
UEDA Ryo 慶應義塾大学, 医学部, 共同研究員 (30317143)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 腫瘍幹細胞 / 免疫療法 / 微小環境 / 脳腫瘍幹細胞 / 免疫抑制 / グリオーマ |
|---|
| Outline of Final Research Achievements |
In this study, we demonstrated that glioma cells and brain tumor stem cells (BTSCs) expressed highly VEGF (vascular endothelial growth factor) and VEGFR (vascular endothelial growth factor receptor) in vitro. Furthermore, VEGFR was shown to express highly within malignant glioma tissues compared with surrounding brain tissue. In a clinical study, we performed a novel immunotherapy using VEGFR1/VEGFR2 peptides in 8 patients with recurrent malignant glioma and analyzed the cytotoxic T lymphocytes (CTLs) specific to VEGFR1/VEGFR2. After the vaccination with VEGFR1/VEGFR2, CTLs specific to VEGFR1 were induced in 6 out of 6 patients analyzed and CTLs specific to VEGFR2 in 2 out of 6 patients. These results suggest that an immunotherapy using VEGFR1/2 peptides to inhibit the VEGF/VEGFR signal may be effective for the treatment of malignant glioma.
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Report
(4 results)
Research Products
(43 results)
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[Presentation] ペプチドワクチンの臨床経験2015
Author(s)
戸田正博
Organizer
第10回信濃町脳腫瘍セミナー
Place of Presentation
慶應義塾大学病院新教育研究棟講堂（東京都）
Year and Date
2015-02-07
Related Report
Invited
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[Presentation] 脳腫瘍の最新治療2014
Author(s)
戸田正博
Organizer
第19回日本脳腫瘍の外科学会 市民公開講座
Place of Presentation
慶應義塾大学病院３号館北棟１階ラウンジ(東京都）
Year and Date
2014-09-14
Related Report
Invited
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