| Project/Area Number |
24659663
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
INUI Hiroshi 東京大学, 医学部附属病院, 助教 (60583119)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Hideya 東京大学, 医学部附属病院, 臨床登録医 (30436464)
TAKETOMI Shuji 東京大学, 医学部附属病院, 助教 (70570018)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 関節病学 |
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| Research Abstract |
We identified transcription factor that induce ADAMTS5, a crucial proteinase for osteoarthritis development by promotor analysis. The endogenous Adamts5 expression in primary chondrocyte derived from knockout mouse of this gene was decreased. In the ex vivo culture of femoral head cartilage from mesenchymal cell-specific knockout of this gene, aggrecanolysis was significantly lower than that in the control cartilage. Finally, we performed the experimental mouse osteoarthritis model in conditional knockout mouse, the conditional knockout of this gene resulted in the acceleration of osteoarthritis development because of the up-regulation of chondrocyte apoptosis. We will investigate moderate suppression of this gene could suppress the osteoarthritis development by using inhibitor of signals related to this gene.
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