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TRPV4, a Ca ion channel plays pivotal role in chondrogenic mechanotransduction in ATDC5

Research Project

Project/Area Number 24659671
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionNagoya University

Principal Investigator

ISHIGURO Naoki  名古屋大学, 医学(系)研究科(研究院), 教授 (20212871)

Co-Investigator(Kenkyū-buntansha) KITOH Hiroshi  名古屋大学, 医学部附属病院, 准教授 (40291174)
SAKAI Tadahiro  名古屋大学, 医学部附属病院, 病院講師 (60378198)
KANEKO Hiroshi  名古屋大学, 大学院医学系研究科, 寄附講座助教 (60566975)
MISHIMA Kenichi  名古屋大学, 大学院医学系研究科, 寄附講座助教 (40646519)
Co-Investigator(Renkei-kenkyūsha) NARUSE Keiji  岡山大学, 大学院医歯薬学総合研究科, 教授 (40252233)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsTRPV4 / SOX9 / 機械的刺激 / 軟骨細胞分化 / ATDC5細胞 / II型コラーゲン / ATDC5 / プロテオグリカン / 機械受容体
Research Abstract

It is well known that chondrocyte metabolic activity is partly regulated by physical factors.However, the specific cellular mechanosensor responsible for perception and transduction has not been fully identified in chondrocytes. It has already reported that TRPV4 activation can contribute to the process of chondrogenesis via SOX9 pathway.In this study we demonstrated that TRPV4 works as a mechanoreceptor in response to mechanical stress in chondrocytes, and to determine the intracellular mechanisms leading to the chondorogensis. Our conclusions are as follow, Mechanical stress promoted chondorogensis in ATDC5 cells with increasing mRNA expression of SOX9. Inhibition of TRPV4 by chmical and siRNA suppressed chondrogenesis effect of mechanical stress in ATDC5 cells. Ca influx by mechanical stress was suppressed by RR supplementation and TRPV4 siRNA transfection.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (58 results)

All 2014 2013 2012

All Journal Article (19 results) (of which Peer Reviewed: 19 results,  Open Access: 2 results) Presentation (35 results) (of which Invited: 2 results) Book (2 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Benign prenatal hypophosphatasia: a treatable disease not to be missed.2014

    • Author(s)
      Matsushita M, Kitoh H, Michigami T, Tachikawa K, Kaneko H, Mishima K, Ishiguro N.
    • Journal Title

      Ped Radiol

      Volume: 44(3) Issue: 3 Pages: 340-343

    • DOI

      10.1007/s00247-013-2805-z

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Perhexiline maleate in the treatment of fibrodysplasia ossificans progressiva: an open-labeled clinical trial.2013

    • Author(s)
      Kitoh H, Achiwa M, Kaneko H, Mishima K, Matsushita M, Kadono I, Horowitz JD, Sallustio BC, Ohno K, Ishiguro N.
    • Journal Title

      Orphanet J Rare Dis.

      Volume: 8 Issue: 1 Pages: 163-163

    • DOI

      10.1186/1750-1172-8-163

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term outcome of gradual reduction using overhead traction for developmental dysplasia of the hip over 6 months of age.2013

    • Author(s)
      Kaneko H, Kitoh H, Mishima K, Matsushita M, Ishiguro N.
    • Journal Title

      J Pediatr Orthop.

      Volume: 33(6) Issue: 6 Pages: 628-34

    • DOI

      10.1097/bpo.0b013e31829b2d8b

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A comparative study of blade plate fixation and external fixation in osteotomies for slipped capital femoral epiphysis.2013

    • Author(s)
      Kitoh H, Kitakoji T, Hattori T, Kaneko H, Mishima K, Matsushita M, Ishiguro N.
    • Journal Title

      J Pediatr Orthop B.

      Volume: 22(6) Issue: 6 Pages: 542-7

    • DOI

      10.1097/bpb.0b013e3283637070

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic factors for trochanteric overgrowth after containment treatment in Legg-Calvé-Perthes disease.2013

    • Author(s)
      Kitoh H, Kaneko H, Mishima K, Matsushita M, Ishiguro N
    • Journal Title

      J Pediatr Orthop B

      Volume: 22 Issue: 5 Pages: 432-436

    • DOI

      10.1097/bpb.0b013e32835f585b

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel in-frame deletion of the RUNX2 gene causes a classic form of cleidocranial dysplasia2013

    • Author(s)
      Mastushita M., Kitoh H., Kaneko H., Mishima K., Itoh Y., Tokita Y., Ishiguro N.
    • Journal Title

      J Bone Miner Metab

      Volume: 未定 Issue: 1 Pages: 96-99

    • DOI

      10.1007/s00774-013-0456-7

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Meclozine facilitates proliferation and differentiation of chondrocytes by attenuating abnormally activated FGFR3 signaling in achondroplasia.2013

    • Author(s)
      Matsushita, M., Kitoh, H., Ohkawara, B., Mishima, K., Kaneko, H., Ito, M., Masuda, A., Ishiguro, N. and Ohno, K.
    • Journal Title

      PLOS ONE

      Volume: 8(12) Issue: 12 Pages: 81569-81569

    • DOI

      10.1371/journal.pone.0081569

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel SOX9 H169Q mutation in a family with overlapping phenotype of mild campomelic dysplasia and small patella syndrome2013

    • Author(s)
      Matsushita M, Kitoh H, Kaneko H, Mishima K, Kadono I, Ishiguro N, Nishmura G
    • Journal Title

      Am J Med Genet A

      Volume: 161 Issue: 10 Pages: 2528-2534

    • DOI

      10.1002/ajmg.a.36134

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SURFACE MARKERS AND GENE EXPRESSION TO CHARACTERIZE THE DIFFERENTIATION OF MONOLAYER EXPANDED HUMAN ARTICULAR CHONDROCYTES2013

    • Author(s)
      TAKASHI HAMADA, TADAHIRO SAKAI, HIDEKI HIRAIWA, MOTOSHIGE NAKASHIMA, YOHEI ONO, HIROHITO MITSUYAMA and NAOKI ISHIGURO
    • Journal Title

      Nagoya J. Med. Sci.

      Volume: 75 Pages: 101-111

    • NAID

      120005227637

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytes.2013

    • Author(s)
      Matsukawa T, Sakai T, Yonezawa T, Hiraiwa H, Hamada T, Nakashima M, Ono Y, Ishizuka S, Nakahara H, Lotz MK, Asahara H, Ishiguro N.
    • Journal Title

      Arthritis Res Ther.

      Volume: 15(1)

    • NAID

      40020134052

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Isolated bifid rib: Clinical and radiological findings in children.2012

    • Author(s)
      Kaneko H, Kitoh H, Mabuchi A, Mishima K, Matsushita M, Ishiguro N.
    • Journal Title

      Pediatr Int

      Volume: 54 Issue: 6 Pages: 820-823

    • DOI

      10.1111/j.1442-200x.2012.03672.x

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 小児疾患の診断治療基準 運動器疾患 軟骨無形成症.2012

    • Author(s)
      鬼頭浩史
    • Journal Title

      小児内科

      Volume: 44 増刊号 Pages: 820-821

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 培養骨髄細胞移植を併用した骨延長術.2012

    • Author(s)
      鬼頭浩史、石黒直樹
    • Journal Title

      現代医学

      Volume: 60(2) Pages: 353-357

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chondroblastoma of the femoral neck as a cause of hip synovitis2012

    • Author(s)
      Kaneko H, Kitoh H, Wasa J, Nishida Y, Ishiguro N
    • Journal Title

      J Pediatr Orthop B

      Volume: 21 Issue: 2 Pages: 179-182

    • DOI

      10.1097/bpb.0b013e3283484c31

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] SOX9遺伝子に変異を認めたsmall patella syndromeの非定型例.2012

    • Author(s)
      金子浩史、鬼頭浩史、馬渕晃好、三島健一、松下雅樹、石黒直樹、西村玄
    • Journal Title

      骨系統疾患研究会記録集

      Volume: 23 Pages: 11-14

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Novel compound heterozygous mutations in the cathepsin K gene in Japanese female siblings with pyknodysostosis.2012

    • Author(s)
      Matsushita M, Kitoh H, Kaneko H, Mishima K, Itoh Y, Hattori T, Ishiguro N.
    • Journal Title

      Mol Syndromol

      Volume: 2 Pages: 254-258

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 特集関節リウマチにおける骨•軟骨病変とその治療 2.関節リウマチの骨•軟骨破壊に対する外科治療 2)軟骨移植2012

    • Author(s)
      酒井忠博、石黒直樹
    • Journal Title

      CLINICAL CALCIUM

      Volume: 22(2) Pages: 89-93

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] MPFL再建+脛骨粗面移行術後の膝蓋骨高に関するX線学的検討ー治療成績評価における各種計測法の違いー2012

    • Author(s)
      酒井忠博、平岩秀樹、濱田恭、山本隆一郎、大間知孝顕、松川哲也、大野洋平、中島基成、石塚真哉、石黒直樹
    • Journal Title

      JOSKAS

      Volume: 37(1) Pages: 156-157

    • NAID

      10030548096

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 骨形成不全症に合併した反復性肩関節脱臼の1例2012

    • Author(s)
      酒井忠博、平岩秀樹、濱田恭、中島基成
    • Journal Title

      肩関節

      Volume: 36(2) Pages: 1075-1077

    • NAID

      130002103516

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Long-term outcome of gradual reduction with overhead traction for developmental dysplasia of the hip in children over six months of age2013

    • Author(s)
      Hiroshi Kaneko, Hiroshi Kitoh, Kenichi Mishima, Masaki Matsushita, Naoki Ishguro
    • Organizer
      Annual meeting of Pediatric Orthopedic Society of North America
    • Place of Presentation
      Sheraton Center Toronto Hotel .(Tronto. Canada)
    • Related Report
      2013 Final Research Report
  • [Presentation] 下肢長不等例における脚長差の経時的変化2013

    • Author(s)
      三島健一、鬼頭浩史、金子浩史、松下雅樹、杉浦洋、長谷川幸、北村暁子、石黒直樹
    • Organizer
      第24回日本小児整形外科学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Final Research Report
  • [Presentation] 大腿骨頭すべり症に対する創外固定法による矯正骨切り術の短期成績?プレート法との比較?2013

    • Author(s)
      鬼頭浩史、金子浩史、三島健一、松下雅樹、石黒直樹
    • Organizer
      第86回日本整形外科学会
    • Place of Presentation
      広島グリーンアリーナリーガロイヤルホテル広島NTTクレドホールメルパルク広島(広島市)
    • Related Report
      2013 Final Research Report
  • [Presentation] Long-term outcome of gradual reduction with overhead traction for developmental dysplasia of the hip in children over six months of age.2013

    • Author(s)
      Hiroshi Kaneko, Hiroshi Kitoh, Kenichi Mishima, Masaki Matsushita, Naoki Ishguro.
    • Organizer
      Annual meeting of Pediatric Orthopedic Society of North America
    • Place of Presentation
      Toronto(Canada)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 大腿骨頭すべり症に対する創外固定法による矯正骨切り術の短期成績―プレート法との比較―.2013

    • Author(s)
      鬼頭浩史、金子浩史、三島健一、松下雅樹、石黒直樹.
    • Organizer
      第86回日本整形外科学会学術総会
    • Place of Presentation
      広島グリーンアリーナ、リーガロイヤルホテル広島、NTTクレドホール、メルパルク広島(広島市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Dysplasia epiphysealis hemimelica generalized typeの右股関節病変について.2013

    • Author(s)
      松下雅樹、鬼頭浩史、金子浩史、三島健一、門野泉、石黒直樹.
    • Organizer
      第52回小児股関節研究会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] A novel Sox9 H169Q mutation in a family with overlapping phenotype of mild campomelic dysplasia and small patella syndrome.2013

    • Author(s)
      Hiroshi Kaneko, Hioroshi Kitoh, Kenichi Mishima, Masaki Matsushita, Naoki Ishiguro.
    • Organizer
      International Skeletal Dysplasia Meeting
    • Place of Presentation
      Bologna(Italy)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Meclozine facilitates chondrocyte proliferation and differentiation by attenuating abnormally activated fibroblast growth factor receptor 3 (FGFR3) signaling in achondroplasia.2013

    • Author(s)
      Masaki Matsushita, Hiroshi Kitoh, Hiroshi Kaneko, Kenichi Mishima, Naoki Ishiguro, Kinji Ohno.
    • Organizer
      International Skeletal Dysplasia Meeting
    • Place of Presentation
      Bologna(Italy)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Meclozineは軟骨無形成症におけるFGFR3シグナルによる軟骨細胞の増殖・分化抑制をレスキューする.2013

    • Author(s)
      松下雅樹、鬼頭浩史、金子浩史、三島健一、石黒直樹、大野欽司.
    • Organizer
      第28回日本整形外科学会基礎学術集会
    • Place of Presentation
      幕張メッセ国際会議場(千葉市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 先天性垂直距骨の外科的治療法の検討.2013

    • Author(s)
      松下雅樹、鬼頭浩史、金子浩史、三島健一、石黒直樹.
    • Organizer
      第17回東海足と靴の研究会
    • Place of Presentation
      興和株式会社 本店ビル(名古屋市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 骨延長後の骨折に関連する因子.2013

    • Author(s)
      鬼頭浩史、金子浩史、三島健一、松下雅樹、門野泉、杉浦洋、長谷川幸、石黒直樹.
    • Organizer
      第24回日本小児整形外科学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] DDH整復後の遺残性臼蓋形成不全に対するソルター骨盤骨切り術の長期成績不良因子.2013

    • Author(s)
      浩史、鬼頭浩史、北小路隆彦、三島健一、松下雅樹、門野泉、杉浦洋、長谷川幸、北村暁子、石黒直樹、服部義.
    • Organizer
      第24回日本小児整形外科学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 下肢長不等例における脚長差の経時的変化.2013

    • Author(s)
      三島健一、鬼頭浩史、金子浩史、松下雅樹、杉浦洋、長谷川幸、北村暁子、石黒直樹.
    • Organizer
      第24回日本小児整形外科学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Potential clinical application of meclizine, an anti-histamine drug, for short stature in FGFR3-related skeletal dysplasias.2013

    • Author(s)
      Masaki Matsushita, Hiroshi Kitoh, Hiroshi Kaneko, Kenichi Mishima, Naoki Ishiguro, Kinji Ohno.
    • Organizer
      第24回日本小児整形外科学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 軟骨無形成症に対する下腿骨延長後の歩行解析.2013

    • Author(s)
      馬渕晃好、鬼頭浩史、金子浩史、三島健一、松下雅樹.
    • Organizer
      第24回日本小児整形外科学会
    • Place of Presentation
      パシフィコ横浜(横浜市)横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 軟骨無形成症に対する下肢骨延長術に伴う下肢関節可動域制限.2013

    • Author(s)
      門野泉、鬼頭浩史、金子浩史、三島健一、松下雅樹、杉浦洋、長谷川幸、杉浦洋、石黒直樹.
    • Organizer
      第24回日本小児整形外科学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Proximal focal femoral deficiencyの重症例.2013

    • Author(s)
      松下雅樹、鬼頭浩史、金子浩史、三島健一、門野泉、西田佳弘、石黒直樹.
    • Organizer
      第25回日本整形外科学会骨系統疾患研究会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 進行性骨化性線維異形成症におけるレントゲン学的診断指針.2013

    • Author(s)
      三島健一、鬼頭浩史、芳賀信彦、中島康晴、金子浩史、松下雅樹、門野泉、西田佳弘、石黒直樹.
    • Organizer
      第25回日本整形外科学会骨系統疾患研究会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒト骨髄由来間葉系幹細胞の細胞増殖能および骨芽細胞分化能2012

    • Author(s)
      鬼頭浩史、金子浩史、三島健一、松下雅樹、石黒直樹
    • Organizer
      第23回日本小児整形外科学会
    • Place of Presentation
      九州大学医学部百年講堂(福岡市)
    • Related Report
      2013 Final Research Report
  • [Presentation] 軟骨無形成症に対する治療の展望2012

    • Author(s)
      鬼頭浩史
    • Organizer
      第85回日本整形外科学会学術総会
    • Place of Presentation
      国立京都国際会館・グランドプリンスホテル京都(京都市)
    • Related Report
      2013 Final Research Report
  • [Presentation] OA治療学の疫学から治療まで 「鎮痛をターゲットとしたOA治療 -可能性と課題-」2012

    • Author(s)
      石黒直樹
    • Organizer
      第56回日本リウマチ学会総会・学術集会 シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] リウマチ頚椎病変は今  「生物製剤のRA頚椎病変に対する進行予防効果」2012

    • Author(s)
      石黒直樹
    • Organizer
      第56回日本リウマチ学会総会・学術集会 シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 先天性股関節脱臼に対する新しい適応を用いたリーメンビューゲルによる短期治療成績2012

    • Author(s)
      鬼頭浩史、金子浩史、松下雅樹、石黒直樹
    • Organizer
      第85回日本整形外科学会学術総会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] 軟骨無形成症に対する治療の展望2012

    • Author(s)
      鬼頭浩史
    • Organizer
      第85回日本整形外科学会学術総会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] 先天性股関節脱臼保存治療後の臼蓋発育についてー幼児期の補正手術の適応を再考するー2012

    • Author(s)
      鬼頭浩史、金子浩史、三島健一、松下雅樹、石黒直樹
    • Organizer
      第51回日本小児股関節研究会
    • Place of Presentation
      千葉
    • Related Report
      2012 Research-status Report
  • [Presentation] Identification and functional characterization of a novel NPR2 mutation (p.R388Q) causing acromesomellic dysplasia, type Maroteaux.2012

    • Author(s)
      Naoko Amano, Hiroshi Kitoh, Satoshi Narumi, Rumi Hachiya, Yoshihiro Ogawa, Gen Nishimura, Tomonobu Hasegawa
    • Organizer
      94th annual meeting of ENDO
    • Place of Presentation
      Houston
    • Related Report
      2012 Research-status Report
  • [Presentation] Proton pump inhibitors commonly used in clinical practice favorably facilitate osteogenesis.2012

    • Author(s)
      三島健一、鬼頭浩史、石黒直樹
    • Organizer
      第30回日本骨代謝学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] ヒト骨髄由来間葉系幹細胞の細胞増殖能および骨芽細胞分化能2012

    • Author(s)
      鬼頭浩史、金子浩史、三島健一、松下雅樹、石黒直樹
    • Organizer
      第23回日本小児整形外科学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] 歩行開始後に診断したDDHに対するoverhead traction法の長期成績2012

    • Author(s)
      金子浩史、鬼頭浩史、三島健一、松下雅樹、石黒直樹
    • Organizer
      第23回日本小児整形外科学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] 3D-CTによる解剖学的二重束前十字靭帯再建術における大腿骨孔の検討2012

    • Author(s)
      與田正樹、高橋成夫、黒河内和俊、山本隆一郎、山本英樹、酒井忠博、石黒直樹
    • Organizer
      第85回日本整形外科学会学術総会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] ロコモティブシンドロームと運動機能の検討2012

    • Author(s)
      中島基成、長谷川幸治、酒井忠博、大間知孝顕、石黒直樹
    • Organizer
      第85回日本整形外科学会学術総会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] 膝軟部肉腫広範切除術後に膝蓋腱及び外側支持機構の再建を行った1例2012

    • Author(s)
      酒井忠博、平岩秀樹、濱田恭、大間知孝顕、中島基成、石塚真哉、小田智之、高松晃、山下暁士、筑紫聡、石黒直樹
    • Organizer
      第4回日本関節鏡・膝・スポーツ整形外科学会
    • Place of Presentation
      沖縄
    • Related Report
      2012 Research-status Report
  • [Presentation] 鏡視下Bankart修復術後成績に影響を与える因子の統計学的検討2012

    • Author(s)
      酒井忠博、平岩秀樹、濱田恭、中島基成、石塚真哉、小田智之、高松晃、山下暁士、石黒直樹
    • Organizer
      第39回日本肩関節学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] S100A12タンパクによる変形性関節症の進行における影響2012

    • Author(s)
      中島基成、酒井忠博、平岩秀樹、濱田恭、石塚真哉、小田智之、高松晃、山下暁士、石黒直樹
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] OA半月板におけるHypoxia-inducible factor-2α の高発現2012

    • Author(s)
      石塚真哉、酒井忠博、平岩秀樹、濱田恭、中島基成、小田智之、高松晃、山下暁士、石黒直樹
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
  • [Book] トピックス2.骨形成促進治療の展望-Runx2を活性化する薬剤の検討?.『先端医療シリーズ44臨床医のための最新整形外科』2013

    • Author(s)
      三島健一、鬼頭浩史、石黒直樹
    • Total Pages
      570
    • Publisher
      先端医療技術研究所
    • Related Report
      2013 Final Research Report
  • [Book] 先端医療シリーズ44 臨床医のための最新整形外科2013

    • Author(s)
      三島健一、鬼頭浩史、石黒直樹 、 戸山芳昭、桃原茂樹、吉川秀樹、越智光夫、松下 隆、吉田宗人、松本守雄、久保俊一、井樋栄二、小宮節郎、土屋弘行、望月一男、田中良哉、松山幸弘、田中 栄、金 郁喆、馬場久敏、等
    • Total Pages
      570
    • Publisher
      先端医療技術研究所
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 骨系統疾患治療薬及びその用途2013

    • Inventor(s)
      大野欽司、石黒直樹、鬼頭浩史、松下雅樹
    • Industrial Property Rights Holder
      国立大学法人名古屋大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-047426
    • Filing Date
      2013-03-10
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 骨形成促進剤及びその用途2012

    • Inventor(s)
      大野欽司、石黒直樹、鬼頭浩史、三島健一
    • Industrial Property Rights Holder
      国立大学法人名古屋大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-08-23
    • Related Report
      2013 Final Research Report
    • Overseas

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Published: 2013-05-31   Modified: 2019-07-29  

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