| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
To elucidate the molecular mechanisms of interaction between cancer cells and microenvironments which determine the osteolytic/ osteogenic tendencies of bone metastases of cancer, series of experiments were performed to establish an in vivo imaging system by which 4 kind of cells, cancer cells, osteoclasts, osteoblasts and osteocytes in bone marrow can be analyzed simultaneously at multiple time points. Cancer cells expressing fluorescent proteins were implanted to mice and bone metastasis system of osteolytic prostate cancer was established. In vivo fluorescence imaging for osteoclast was also performed.
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