| Project/Area Number |
24659683
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
ARAI Yuji 京都府立医科大学, 医学(系)研究科(研究院), 講師 (50347449)
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| Co-Investigator(Kenkyū-buntansha) |
KISHIDA Tsunao 京都府立医科大学, 医学研究科, 講師 (00370205)
KUBO Toshikazu 京都府立医科大学, 医学研究科, 教授 (20178031)
TERAUCHI Ryu 京都府立医科大学, 医学研究科, 講師 (20575154)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ミオスタチン / hiPS細胞 / 筋芽細胞 / siRNA / 筋力訓練 / 変形性関節症 |
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| Research Abstract |
Myostatin negatively regulates proliferation of satellite cells that are tissue resident stem cells in the skeletal muscle, as well as differentiation of myoblasts into myotubes. Myostatin is crucially involved in pathogenesis of some diseases including cachexia, while recent studies have clarified its important roles in the control of carbohydrate and lipid metabolism. Blocking of Myostatin signal may provide novel therapeutic modality to prevent and improve atrophic conditions in cachexia and sarcopenia, and to control obesity and diabetes as well.
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