Physiological function of hydrogen sulfide in osteoblasts.
| Project/Area Number |
24659686
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 骨代謝 / ガスバイオロジー / 骨・軟骨代謝 |
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| Research Abstract |
Hydrogen sulfide has been recognized as a gaseous mediator with a variety of physiological functions. However, its role in the control of skeletal function is unknown. Hydrogen sulfide can be physiologically generated by enzymes, cystathionine beta-synthase (CBS). To define the physiological function of hydrogen sulfide in the skeletal tissue, we performed functional analysis of bone metabolism in CBS knockout mice. The knockout mice showed significant growth retardation and various skeletal disorders. These results suggest that hydrogen sulfide is essential for normal bone metabolism.
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Report
(3 results)
Research Products
(7 results)
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[Journal Article] Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis2012
Author(s)
Hirose, Y., Saijou, E., Sugan,o Y., Takeshita, F., Nishimura, S., Nonaka, H., Chen, Y.R., Sekine, K., Kido, T., Nakamura, T., Kato, S., Kanke, T., Nakamura, K., Nagai, R., Ochiya, T., Miyajima, A.
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Journal Title
Proc.Natl.Acad.Sci.USA
Volume: 109
Issue: 11
Pages: 4263-4268
DOI
Related Report
Peer Reviewed
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