Physiological function of hydrogen sulfide in osteoblasts.

• Project/Area Number: 24659686
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Keio University
• Principal Investigator: NAKAMURA Takashi 慶應義塾大学, 医学部, 助教 (80431948)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 骨代謝 / ガスバイオロジー / 骨・軟骨代謝

Research Abstract

Hydrogen sulfide has been recognized as a gaseous mediator with a variety of physiological functions. However, its role in the control of skeletal function is unknown. Hydrogen sulfide can be physiologically generated by enzymes, cystathionine beta-synthase (CBS). To define the physiological function of hydrogen sulfide in the skeletal tissue, we performed functional analysis of bone metabolism in CBS knockout mice. The knockout mice showed significant growth retardation and various skeletal disorders. These results suggest that hydrogen sulfide is essential for normal bone metabolism.

Research Products

• [Journal Article] エストロゲン受容体ノックアウトマウスを用いた研究の発展 (2013)
  • Author(s): 加藤茂明、中村貴
  • Journal Title: O.li.v.e.-骨代謝と生活習慣病の連関- Pages: 52-55
  • URL: http://www.m-review.co.jp/magazine/detail/J71_03_02
• [Journal Article] Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis (2012)
  • Author(s): Hirose, Y., Saijou, E., Sugan,o Y., Takeshita, F., Nishimura, S., Nonaka, H., Chen, Y.R., Sekine, K., Kido, T., Nakamura, T., Kato, S., Kanke, T., Nakamura, K., Nagai, R., Ochiya, T., Miyajima, A.
  • Journal Title: Proc.Natl.Acad.Sci.USA Volume: 109 Issue: 11 Pages: 4263-4268
  • DOI: 10.1073/pnas.1117560109
  • Peer Reviewed
• [Presentation] Wnt5a-Ror2シグナルは、Daam2-Rhoを介して骨吸収機能を促進する (2014)
  • Author(s): 上原俊介、山下照仁、中村貴、加藤茂明、宇田川信之、高橋直之、小林泰浩
  • Organizer: 第32回日本骨代謝学会学術集会
  • Place of Presentation: 日大阪国際会議場
• [Presentation] Transgenic expression of mouse Fra-1 in osteoblasts reduces bone mineralization in medaka fish (2012)
  • Author(s): Tomohiro Matsumoto, Yasunari Takada, Takashi Nakamura, Makoto Suematsu, Keiji Inohaya, Akira Kudo, Atsushi Shimizu, and Koichi Matsuo
  • Organizer: 18th Japanese Medaka and Zebrafish Meeting
  • Place of Presentation: Kyoto University
• [Remarks] 慶應義塾大学医学部医化学教
  • URL: http://www.gasbiology.com/
• [Remarks] 慶應義塾大学医学部医化学教室
  • URL: http://www.gasbiology.com
• [Remarks] 慶應義塾大学医学部・医化学教室
  • URL: http://www.gasbiology.com