Pharmacological mechanisms of locus coeruleus activation -recruitment of descending inhibition for treatment of neuropathic pain-
| Project/Area Number |
24659691
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Gunma University |
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Principal Investigator |
OBATA Hideaki 群馬大学, 医学(系)研究科(研究院), 准教授 (20302482)
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|---|
| Co-Investigator(Renkei-kenkyūsha) |
MIEDA Rie 群馬大学, 医学部附属病院, 助教 (10400772)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | ノルアドレナリン / 脊髄 / α2受容体 / ラット |
|---|
| Research Abstract |
Pregabalin and gabapentin are often used as first-line drugs in the treatment of neuropathic pain. Previous studies suggest that these drugs activate descending inhibitory systems. In the present project, using rats, we observed that systemic administration of pregabalin increased noradrenaline level in the dorsal horn of the lumbar spinal cord through activation of locus coeruleus. The increased noradrenaline inhibit not only neuropathic pain but also acute pain via spinal alpha-2 adrenoceptors. The mechanisms by which pregabalin activates locus coeruleus are still under active investigation.
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Report
(3 results)
Research Products
(39 results)
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[Presentation] 痛みの下行性制御2013
Author(s)
小幡英章
Organizer
第7回日本緩和医療薬学会年会ランチョンセミナー
Place of Presentation
さいたま市
Year and Date
2013-09-15
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[Book] 臨床麻酔2012
Author(s)
木村雅文, 小幡英章
Total Pages
6
Publisher
トラマドール
Related Report
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[Book] Lisa2012
Author(s)
小幡英章
Total Pages
5
Publisher
痛みのバイオロジー, 下行性制御：抑制と促進
Related Report
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[Book] 臨床麻酔2012
Author(s)
木村雅文, 小幡英章
Total Pages
7
Publisher
術後鎮痛の薬理学的研究
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