• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Pain treatment by using induced neuronal cell

Research Project

Project/Area Number 24659692
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Anesthesiology/Resuscitation studies
Research InstitutionChiba University

Principal Investigator

AOE Tomohiko  千葉大学, 医学(系)研究科(研究院), 准教授 (90311612)

Co-Investigator(Kenkyū-buntansha) KOMITA Mari  千葉大学, 医学部附属病院, 医員 (90589194)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords再生医学、 / 神経科学 / 再生医学 / 神経障害性疼痛 / 転換神経細胞
Research Abstract

For future clinical application, we tried to convert a mouse fibroblast into nerve cells and examined a method to derive it, in order to isolate GABAergic nerve cells. We prepared neuropathic pain model mice for intrathecal administration of the separation cells on a trial basis, to consider whether neuropathic sharp pain would be reduced.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (22 results)

All 2013 2012 Other

All Journal Article (7 results) (of which Peer Reviewed: 1 results) Presentation (13 results) Book (2 results)

  • [Journal Article] The effect of endoplasmic reticulum stress on neurotoxicity caused by inhaled anesthetics2013

    • Author(s)
      Komita, M., Jin, H,. Aoe, T
    • Journal Title

      Anesthesia&Analgesia

      Volume: 117 Issue: 5 Pages: 1197

    • DOI

      10.1213/ane.0b013e3182a74773

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 小胞体ストレス反応とオピオイド耐性2013

    • Author(s)
      青江知彦
    • Journal Title

      退薬症状

      Volume: 麻酔62 Pages: 289-289

    • URL

      http://www.de-hon.ne.jp/digital/bin/product.asp?sku=1491008313033300400P

    • Related Report
      2013 Final Research Report
  • [Journal Article] 小胞体ストレスと神経系細胞2013

    • Author(s)
      青江知彦
    • Journal Title

      Anesthesia 21 Century

      Volume: 15 Pages: 16-23

    • URL

      http://www.maruishi-pharm.co.jp/med2/files/anesth/book/3/4.pdf?1366097691

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
  • [Journal Article] 小胞体ストレスと疾患2013

    • Author(s)
      小見田真理、奥山陽太、神久予、磯野史朗、青江知彦
    • Journal Title

      千葉医学雑誌

      Volume: 89巻 Pages: 87-94

    • NAID

      10031200368

    • URL

      http://mitizane.ll.chiba-u.jp/metadb/up/igakukai/89-3-87.pdf

    • Related Report
      2013 Final Research Report
  • [Journal Article] 小胞体ストレスと疾患2013

    • Author(s)
      小見田 真理、奥山陽太、神久予、磯野史朗、青江知彦
    • Journal Title

      千葉医学雑誌

      Volume: 89 Pages: 87-94

    • NAID

      10031200368

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 小胞体ストレス反応とオピオイド耐性, 退薬症状2013

    • Author(s)
      青江知彦
    • Journal Title

      麻酔

      Volume: 62 Pages: 283-289

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 小胞体ストレス反応とオピオイド耐性、退薬症状2013

    • Author(s)
      青江知彦
    • Journal Title

      麻酔

      Volume: 62

    • Related Report
      2012 Research-status Report
  • [Presentation] 化学シャペロンによるオピオイド耐性形成の抑制2013

    • Author(s)
      青江知彦
    • Organizer
      第8回臨床ストレス応答学会大会プログラム
    • Place of Presentation
      松本
    • Year and Date
      2013-11-15
    • Related Report
      2013 Final Research Report
  • [Presentation] 小胞体シャペロンBiPのソーテイング異常によって起こる発生過程から老年期に見られる病態2013

    • Author(s)
      青江知彦
    • Organizer
      日本細胞生物学会2013
    • Place of Presentation
      名古屋
    • Year and Date
      2013-06-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 吸入麻酔薬による神経障害と小胞体ストレス2013

    • Author(s)
      青江知彦,小見田真理,奥山陽太,神久予
    • Organizer
      日本麻酔科学会第60回学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2013-05-23
    • Related Report
      2013 Final Research Report
  • [Presentation] 化学シャペロンを用いたモルヒネ耐性形成抑制の実験2013

    • Author(s)
      奥山陽太, 神久予, 磯野史朗, 青江知彦
    • Organizer
      日本麻酔科学会第60回学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2013-05-23
    • Related Report
      2013 Final Research Report
  • [Presentation] 吸入麻酔薬による神経細胞障害と小胞体ストレス2012

    • Author(s)
      小見田真理, 神久予,青江知彦
    • Organizer
      第7回臨床ストレス応答学会
    • Place of Presentation
      東京
    • Year and Date
      2012-11-24
    • Related Report
      2013 Final Research Report
  • [Presentation] 変異BiPノックインマウスの加齢病変2012

    • Author(s)
      青江知彦, 三村尚也, 木村敬太, 小見田真理, 奥山陽太, 神久予
    • Organizer
      第7回臨床ストレス応答学会
    • Place of Presentation
      東京
    • Year and Date
      2012-11-24
    • Related Report
      2013 Final Research Report
  • [Presentation] The influence of endoplasmic reticulum stress on neurotoxicity caused by inhalational anesthetics American2012

    • Author(s)
      Aoe, T., Komita, M., Aono, M., Okuyama, Y., Jin, H
    • Organizer
      Society of Anesthesiologists annual meeting 2012
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2012-10-14
    • Related Report
      2013 Final Research Report
  • [Presentation] 吸入麻酔薬による神経障害と小胞体ストレス2012

    • Author(s)
      小見田真理、青江知彦、神久予
    • Organizer
      日本麻酔科学会第59回学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2012-06-07
    • Related Report
      2013 Final Research Report
  • [Presentation] 化学シャペロンを用いたモルヒネ耐性形成抑制の実験

    • Author(s)
      奥山陽太 神久予 磯野史朗 青江知彦
    • Organizer
      日本麻酔科学会 第60 回学術集会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] 吸入麻酔薬による神経障害と小胞体ストレス

    • Author(s)
      青江 知彦, 小見田 真理, 奥山陽太,神 久予
    • Organizer
      日本麻酔科学会 第60 回学術集会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] 小胞体シャペロンBiPのソーテイング異常によって起こる発生過程から老年期に見られる病態

    • Author(s)
      青江 知彦
    • Organizer
      日本細胞生物学会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 化学シャペロンによるオピオイド耐性形成の抑制

    • Author(s)
      青江知彦
    • Organizer
      第8 回臨床ストレス応答学会
    • Place of Presentation
      松本
    • Related Report
      2013 Annual Research Report
  • [Presentation] The influence of endoplasmic reticulum stress on neurotoxicity caused by inhalational anesthetics.

    • Author(s)
      Aoe, T., Komita, M., Aono, M., Okuyama, Y., Jin, H.
    • Organizer
      American Society of Anesthesiologists annual meeting
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2012 Research-status Report
  • [Book] In"Analgesics : New Research" Vivian Jacobs and Alexander Lang, Modulation of the development of morphine antinociceptive tolerance by endoplasmic reticulum chaperones2012

    • Author(s)
      Tomohiko Aoe, Ed
    • Related Report
      2013 Final Research Report
  • [Book] Modulation of the development of morphine antinociceptive tolerance by endoplasmic reticulum chaperones. In“Analgesics: New Research”2012

    • Author(s)
      Tomohiko Aoe, Ed. Vivian Jacobs and Alexander Lang
    • Publisher
      Nova Science Publishers, Inc NY, USA
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi