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Development of novel therapies for itch by a positive charged lidocaine

Research Project

Project/Area Number 24659693
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Anesthesiology/Resuscitation studies
Research InstitutionShinshu University

Principal Investigator

KAWAMATA Tomoyuki  信州大学, 医学部, 准教授 (80336388)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords痒み / 局所麻酔薬 / イミキモド / カプサイシン / TRPV1 / QX314 / Itch
Research Abstract

Recently, it has been reported that a positive-charged lidocaine produces local anesthestic effects through the activated TRPV1. In this study, we examined whether a positive-charged lidocaine QX-314 has anti-antipruritic effects on imiquimod-induced itch, which is evoked through the activation of TRPV1. We found that QX-314 selectively inhibited miquimod-induced itch without any effects on touch sensation and pain. Our results suggested that a positive charged lidocaine have beneficial effects on symptoms induced by TRPV1 activation with lesser side effects.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (29 results)

All 2013 2012

All Journal Article (12 results) (of which Peer Reviewed: 7 results) Presentation (7 results) (of which Invited: 5 results) Book (10 results)

  • [Journal Article] 外套細胞より供給されるL-セリンに注目した化学療法誘起末梢神経障害の機序2013

    • Author(s)
      川股知之, 木谷友洋
    • Journal Title

      日薬理誌

      Volume: 141 Pages: 71-75

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] がん性腹膜炎による難治性疼痛の病態解析2013

    • Author(s)
      鈴木雅美, 成田年, 川股知之, 的場元弘, 上園保仁
    • Journal Title

      ペインクリニック

      Volume: 34 Pages: 255-262

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] がんの神経浸潤と痛みにおけるがん細胞と神経のクロストーク2013

    • Author(s)
      鈴木雅美, 川股知之, 成田年, 上園保仁
    • Journal Title

      ペインクリニック

      Volume: 34 Pages: 625-63

    • Related Report
      2013 Final Research Report
  • [Journal Article] がんの神経浸潤と痛みにおけるがん細胞と神経のクロストーク2013

    • Author(s)
      鈴木雅美, 川股知之, 成田 年, 上園保仁
    • Journal Title

      ペインクリニック

      Volume: 34 Pages: 625-633

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sensation of abdominal pain induced by peritoneal carcinomatosis is accompanied by changes in the expression of substance P andμ-opioid receptors in the spinal cord of mice2012

    • Author(s)
      Suzuki M, Narita M, Hasegawa M, Furuta S, Kawamata T, Ashizawa M, Miyano K, Yanagihara K, Chiwaki F, Suzuki T, Matoba M, Sasaki H, Uezono Y
    • Journal Title

      Anesthesiology

      Volume: 117 Pages: 847-56

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 疼痛治療の薬理学-末梢から脊髄への痛みの伝達-2012

    • Author(s)
      川股知之
    • Journal Title

      BRAIN MEDICAL

      Volume: 90 Pages: 7-12

    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Journal Article] がん疼痛の発生メカニズム2012

    • Author(s)
      川真田樹人,川股知之
    • Journal Title

      薬局

      Volume: 63 Pages: 15-20

    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Journal Article] 骨転移痛のメカニズムと鎮痛薬による薬物療法2012

    • Author(s)
      川股知之,布施谷仁志,山本克己,石田高志,平林高暢,川真田樹人
    • Journal Title

      ペインクリニック

      Volume: 33 Pages: 1353-60

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 骨転移痛のメカニズムと鎮痛薬による薬物療法2012

    • Author(s)
      川股知之,布施谷仁志,山本克己,石田高志,平林高暢,川真田樹人
    • Journal Title

      ペインクリニック

      Volume: 33 Pages: 1353-1360

    • Related Report
      2012 Research-status Report
  • [Journal Article] Acute neurogenic pulmonary edema following electroconvulsive therapy: a case report2012

    • Author(s)
      Takahashi T, Kinoshita K, Fuke T, Urushihata K, Kawamata T, Yanagisawa S, Kaneko T, Washizuka S, Hanihara T, Amano N
    • Journal Title

      Gen Hosp Psychiatry

      Volume: 34

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Misplacement of a guidewire into the vertebral vein through the internal juglar vein2012

    • Author(s)
      Ide S, Kawamata T, Imai N, Ando A, Kawamata M
    • Journal Title

      J Cardiothorac Vasc Anesth

      Volume: 26 Pages: 17-18

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sensation of abdominal pain induced by peritoneal carcinomatosis is accompanied by changes in the expression of substance P and -opioid receptors in the spinal cord of mice2012

    • Author(s)
      Suzuki M, Narita M, Hasegawa M, Furuta S, Kawamata T, Ashizawa M, Miyano K, Yanagihara K, Chiwaki F, Suzuki T, Matoba M, Sasaki H, Uezono Y
    • Journal Title

      Anesthesiology

      Volume: 117 Pages: 847-856

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Lumbar epidural anesthesia does not affect the suppressive effect of landiolol on endotracheal intubation-induced tachycardia2013

    • Author(s)
      Urasawa M, Kawamata T, Shimizu F, SAndo N, Kitoh T, Ina H, Sasao J, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      San Francisco
    • Related Report
      2013 Annual Research Report
  • [Presentation] レミフェンタニルは術後痛を増強するのか?2013

    • Author(s)
      川股知之
    • Organizer
      日本臨床麻酔学会第33回大会
    • Place of Presentation
      金沢
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] がんの痛みのメカニズム2012

    • Author(s)
      川股知之
    • Organizer
      日本麻酔科学会第59回学術集会
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Role of satellite cell-derived L-serine in the dorsal root ganglionin paclitaxel-induced peripheral neuropathy2012

    • Author(s)
      Kawamata T
    • Organizer
      The 85th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Final Research Report
  • [Presentation] がんの痛みのメカニズム2012

    • Author(s)
      川股知之
    • Organizer
      日本麻酔科学会第59回学学術集会
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] TRPV2 is involved in bone cancer-induced movement-evoked pain but not ongoing pain2012

    • Author(s)
      Yamamoto K, Kawamata T, Ide S, Ishida T, Kawamata M
    • Organizer
      42nd Annual meeting of Society for Neuroscience
    • Place of Presentation
      New Orleans
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] TRPV1-positive afferents and IB4-binding afferents sense different modalities of hyperalgesia in an incisional pain model2012

    • Author(s)
      Kawamata T, Ishida KM, Tanaka H, Kawamata Y, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      Washington DC
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] 2.薬物療法.VIII.骨粗鬆症の疼痛管理.最新の骨粗鬆症学-骨粗鬆症最新の知見-2013

    • Author(s)
      川股知之
    • Publisher
      東京,日本臨牀社
    • Related Report
      2013 Final Research Report
  • [Book] ①骨転移. 2.がん性痛.VI.痛みの原因と鎮痛薬の選択.痛みのScience & Practice第3巻痛みの薬物治療(山本達郎編)2013

    • Author(s)
      布施谷仁志, 川股知之
    • Publisher
      東京,文光堂
    • Related Report
      2013 Final Research Report
  • [Book] ②がんによる神経障害性痛. 2.がん性痛.VI.痛みの原因と鎮痛薬の選択.痛みのScience & Practice第3巻痛みの薬物治療(山本達郎編)2013

    • Author(s)
      川股知之
    • Publisher
      東京,文光堂
    • Related Report
      2013 Final Research Report
  • [Book] 2.骨転移痛.I.がん疼痛の発生機序と治療.病態疾患別がん性疼痛の治療(井関雅子編)2013

    • Author(s)
      川股知之
    • Publisher
      東京,文光堂
    • Related Report
      2013 Final Research Report
  • [Book] 病態疾患別がん性疼痛の治療2013

    • Author(s)
      川股知之
    • Publisher
      文光堂
    • Related Report
      2013 Annual Research Report
  • [Book] 末梢神経でのmuオピオイド受容体発現と鎮痛効果.I.鎮痛機序.第2章ペインクリニック・緩和医療.垣花学・成田年編.オピオイド基礎を知って臨床で使いこなす2012

    • Author(s)
      川股知之
    • Publisher
      克誠堂出版,東京
    • Related Report
      2013 Final Research Report
  • [Book] 2.骨痛の緩和療法.IV.骨痛のメカニズムと緩和療法.がん骨転移のバイオロジーとマネージメント(米田俊之編)2012

    • Author(s)
      川股知之
    • Publisher
      医薬ジャーナル社
    • Related Report
      2013 Final Research Report
  • [Book] For Professional Anesthesiologists 麻酔・疼痛管理・集中治療領域におけるα2受容体作動薬2012

    • Author(s)
      川股知之
    • Total Pages
      355
    • Publisher
      克誠堂出版
    • Related Report
      2012 Research-status Report
  • [Book] オピオイド 基礎を知って臨床で使いこなす2012

    • Author(s)
      川股知之
    • Total Pages
      208
    • Publisher
      克誠堂出版
    • Related Report
      2012 Research-status Report
  • [Book] がん骨転移のバイオロジーとマネージメント2012

    • Author(s)
      川股知之
    • Total Pages
      399
    • Publisher
      医薬ジャーナル社
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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