| Project/Area Number |
24659694
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ISHIDA Takashi 信州大学, 医学部附属病院, 医員 (60531952)
ISHIDA Kumiko 信州大学, 医学部附属病院, 助教(診療) (80467191)
MINEMURA Hitoshi 信州大学, 医学部附属病院, 特任研究員 (40635877)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 局所麻酔薬 / 神経毒性 / 痙攣 / 呼吸停止 / リドカイン / 血中濃度 / 髄液内濃度 / 発達脳 / 脳内濃度 / 発達 |
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| Research Abstract |
In order to examine the differences in the toxicity of local anesthetics to the immature and mature brain, adult rats (8 w-old) and neonates (PO7-21) were used. Electrodes for measuring electroencephalograhy were implanted, and a PE10 catheter was inserted into the external jugular vein. Then intravenous infusion of lidocaine was started. When seizure and respiratory arrest were seen, cerebrospinal fluid and arterial blood were collected. The concentrations of lidocaine in the plasma and cerebrospinal fluid were significant higher than those in the adult rats. The results suggest that the developing brain in the rat is resistant to systemic toxicity of local anesthetics, compared to the mature brain.
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