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Usefulness of volatile biomarkers in breath for perioperative management

Research Project

Project/Area Number 24659700
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Anesthesiology/Resuscitation studies
Research InstitutionKagoshima University

Principal Investigator

MATSUNAGA Akira  鹿児島大学, 医歯(薬)学総合研究科, 准教授 (70284883)

Co-Investigator(Kenkyū-buntansha) SHIMSANOE Kengo  九州大学, 総合理工学部, 教授 (10274531)
垣花 泰之  鹿児島大学, 医歯(薬)学総合研究科, 教授 (20264426)
Co-Investigator(Renkei-kenkyūsha) KAKIHANA Yasuyuki  鹿児島大学, 医歯学総合研究科, 教授 (20264426)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsガスセンサ / 揮発性有機化合物(VOCs) / 患者評価 / VOCs / 呼気ガス分析 / 半導体式ガスセンサ / 接触燃焼式ガスセンサ / 周術期管理 / 呼気ガスバイオマーカー
Research Abstract

The aim of this study was to identify the useful volatile organic compounds (VOCs) in breath for evaluating perioperative patients, and to develop the accurate gas sensor for measuring the concentration of the VOCs. Changes in VOCs in breath were analyzed by gas chromatography in patients who underwent highly invasive operations. However, the useful volatile biomarkers were not identified.
Water vapor content and lowing catalytic activity decreased the accuracy of gas sensor for measuring VOCs.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (19 results)

All 2014 2013 2012

All Journal Article (13 results) (of which Peer Reviewed: 13 results,  Open Access: 1 results) Presentation (5 results) Book (1 results)

  • [Journal Article] Nanoparticle cluster gas sensor : controlled clustering of SnO_2 nanoparticles for highly sensitive toluene detection2014

    • Author(s)
      Suematsu K, Shin Y, Hua Z, Yoshida K, Yuasa M, Kida T, Shimanoe K
    • Journal Title

      ACS Appl Mater Interfaces

      Volume: 6 Pages: 5319-26

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Perfusion index as a possible predictor for postanesthetic shivering2014

    • Author(s)
      Kuroki C, Godai K, Hasegawa-Moriyama M, Kuniyoshi T, Matsunaga A, Kanmura Y, Kuwaki T
    • Journal Title

      J Anesth

      Volume: 28 Pages: 19-25

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suspected intraoperative formation of left atrial thrombus in a patient with atrial fibrillation receiving bridging anticoagulation therapy.2014

    • Author(s)
      Godai K, Hasegawa-Moriyama M, Unoki K, Uchida Y, Kuniyoshi T, Matsunaga A, Kanmura Y.
    • Journal Title

      J Anesth.

      Volume: 28 Issue: 1 Pages: 112-115

    • DOI

      10.1007/s00540-013-1664-y

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Perfusion index as a possible predictor for postanesthetic shivering.2014

    • Author(s)
      Kuroki C, Godai K, Hasegawa-Moriyama M, Kuniyoshi T, Matsunaga A, Kanmura Y, Kuwaki T.
    • Journal Title

      J Anesth.

      Volume: 28 Issue: 1 Pages: 19-25

    • DOI

      10.1007/s00540-013-1658-9

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recombinant Thrombomodulin Protects Mice against Histone-Induced Lethal Thromboembolism2013

    • Author(s)
      Nakahara M, Ito T, Kawahara KI, Yamamoto M, Nagasato T, Shrestha B, Yamada S, Miyauchi T, Higuchi K, Takenaka T, Yasuda T, Matsunaga A, Kakihana Y, Hashiguchi T, Kanmura Y, Maruyama I
    • Journal Title

      PLoS One

      Volume: 30:8 Pages: 75961-75961

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Remifentanil temporarily improves renal function in adult patients with chronic kidney disease undergoing orthopedic surgery2013

    • Author(s)
      Terashi T, Takehara A, Kuniyoshi T, Matsunaga A, Kawasaki K, Kanmura Y
    • Journal Title

      J Anesth

      Volume: 27 Pages: 340-5

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased carboxyhemoglobin level during liver resection with inflow occlusion2013

    • Author(s)
      Godai K, Hasegawa-Moriyama M, Kuniyoshi T, Matsunaga A, Kanmura Y
    • Journal Title

      J Anesth

      Volume: 27 Pages: 306-8

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased carboxyhemoglobin level during liver resection with inflow occlusion.2013

    • Author(s)
      Godai K, Hasegawa-Moriyama M, Kuniyoshi T, Matsunaga A, Kanmura Y.
    • Journal Title

      J Anesth.

      Volume: 27 Issue: 2 Pages: 306-308

    • DOI

      10.1007/s00540-012-1513-4

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Remifentanil temporarily improves renal function in adult patients with chronic kidney disease undergoing orthopedic surgery.2013

    • Author(s)
      Terashi T, Takehara A, Kuniyoshi T, Matsunaga A, Kawasaki K, Kanmura Y.
    • Journal Title

      J Anesth

      Volume: 27 Issue: 3 Pages: 340-345

    • DOI

      10.1007/s00540-012-1545-9

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recombinant thrombomodulin protects mice against histone-induced lethal thromboembolism.2013

    • Author(s)
      Nakahara M, Ito T, et al.
    • Journal Title

      PLoS One

      Volume: 8(9) Issue: 9 Pages: 75961-75961

    • DOI

      10.1371/journal.pone.0075961

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three cases of suspected sugammadex-induced hypersensitivity reactions2012

    • Author(s)
      Godai K, Hasegawa-Moriyama M, Kuniyoshi T, Kakoi T, Ikoma K, Isowaki S, Matsunaga A, Kanmura Y
    • Journal Title

      British journal of Anesthesia

      Volume: 109 Issue: 2 Pages: 216-8

    • DOI

      10.1093/bja/aes137

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of pneumoperitoneum on functional residual capacity2012

    • Author(s)
      Matsunaga A, Ohse K, Kakihana Y, Masuda M, Ikoma K, Kanmura Y
    • Journal Title

      Advances in Experimental Medicine and Biology

      Volume: 737 Pages: 239-43

    • DOI

      10.1007/978-1-4614-1566-4_35

    • ISBN
      9781461415657, 9781461415664
    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cerebral monitoring using near-infrared time-resolved spectroscopy and postoperative cognitive dysfunction2012

    • Author(s)
      Kakihana Y, Okayama N, Matsunaga A, Yasuda T, Imabayashi T, Nakahara M, Kiyonaga N, Ikoma K, Kikuchi T, Kanmura Y, Oda M, Ohmae E, Suzuki T, Yamashita Y, Tamura M
    • Journal Title

      Advances in Experimental Medicine and Biology

      Volume: 737 Pages: 19-24

    • DOI

      10.1007/978-1-4614-1566-4_3

    • ISBN
      9781461415657, 9781461415664
    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 多波長パルスオキシメータによるメトヘモグロビン血症患者モニタリング2013

    • Author(s)
      松永明、磯脇純和、上村裕一
    • Organizer
      第35回日本手術医学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 麻酔科領域におけるタブレットツールの応用2012

    • Author(s)
      松永明、磯脇純和、上村裕一
    • Organizer
      第34回日本手術医学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of low-dose carperitide on hemodynamic stability in postoperative patients undergoing cardiovascular surgery2012

    • Author(s)
      T. Imabayashi, A. Matsunaga, M. Hasegawa, K. Ikoma, N. Kiyonaga, Y. Kanmura
    • Organizer
      Euroanaesthesia
    • Place of Presentation
      Paris, France
    • Related Report
      2012 Research-status Report
  • [Presentation] Perfusion Index as a Predictive Factor of Postoperative Shivering2012

    • Author(s)
      A. Yoshikawa, M. Hasegawa-Moriyama, C. Kuroki, K. Godai, K. Enohata, A. Matsunaga, Y. Kanmura
    • Organizer
      American Society of Anesthesiologists Annual Meeting
    • Place of Presentation
      Washington, DC, United States
    • Related Report
      2012 Research-status Report
  • [Presentation] Carboxyhemoglobin Level Reflects Hepatic Ischemia During Liver Resection With Inflow Occlusion2012

    • Author(s)
      K. Godai, M. Hasegawa-Moriyama, A. Yoshikawa, K. Enohata, A. Matsunaga, Y. Kanmura
    • Organizer
      American Society of Anesthesiologists Annual Meeting
    • Place of Presentation
      Washington, DC, United States
    • Related Report
      2012 Research-status Report
  • [Book] 麻酔科医のための循環管理の実際2013

    • Author(s)
      松永 明、上村裕一
    • Total Pages
      307
    • Publisher
      中山書店
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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