Usefulness of volatile biomarkers in breath for perioperative management

• Project/Area Number: 24659700
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Kagoshima University
• Principal Investigator: MATSUNAGA Akira 鹿児島大学, 医歯(薬)学総合研究科, 准教授 (70284883)
• Co-Investigator(Kenkyū-buntansha): SHIMSANOE Kengo 九州大学, 総合理工学部, 教授 (10274531) ; 垣花 泰之 鹿児島大学, 医歯(薬)学総合研究科, 教授 (20264426)
• Co-Investigator(Renkei-kenkyūsha): KAKIHANA Yasuyuki 鹿児島大学, 医歯学総合研究科, 教授 (20264426)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: ガスセンサ / 揮発性有機化合物(ＶＯＣｓ） / 患者評価 / VOCs / 呼気ガス分析 / 半導体式ガスセンサ / 接触燃焼式ガスセンサ / 周術期管理 / 呼気ガスﾊﾞｲｵﾏｰｶｰ

Research Abstract

The aim of this study was to identify the useful volatile organic compounds (VOCs) in breath for evaluating perioperative patients, and to develop the accurate gas sensor for measuring the concentration of the VOCs. Changes in VOCs in breath were analyzed by gas chromatography in patients who underwent highly invasive operations. However, the useful volatile biomarkers were not identified.
Water vapor content and lowing catalytic activity decreased the accuracy of gas sensor for measuring VOCs.

Research Products

• [Journal Article] Nanoparticle cluster gas sensor : controlled clustering of SnO_2 nanoparticles for highly sensitive toluene detection (2014)
  • Author(s): Suematsu K, Shin Y, Hua Z, Yoshida K, Yuasa M, Kida T, Shimanoe K
  • Journal Title: ACS Appl Mater Interfaces Volume: 6 Pages: 5319-26
  • Peer Reviewed
• [Journal Article] Perfusion index as a possible predictor for postanesthetic shivering (2014)
  • Author(s): Kuroki C, Godai K, Hasegawa-Moriyama M, Kuniyoshi T, Matsunaga A, Kanmura Y, Kuwaki T
  • Journal Title: J Anesth Volume: 28 Pages: 19-25
  • Peer Reviewed
• [Journal Article] Suspected intraoperative formation of left atrial thrombus in a patient with atrial fibrillation receiving bridging anticoagulation therapy. (2014)
  • Author(s): Godai K, Hasegawa-Moriyama M, Unoki K, Uchida Y, Kuniyoshi T, Matsunaga A, Kanmura Y.
  • Journal Title: J Anesth. Volume: 28 Issue: 1 Pages: 112-115
  • DOI: 10.1007/s00540-013-1664-y
  • Peer Reviewed
• [Journal Article] Perfusion index as a possible predictor for postanesthetic shivering. (2014)
  • Author(s): Kuroki C, Godai K, Hasegawa-Moriyama M, Kuniyoshi T, Matsunaga A, Kanmura Y, Kuwaki T.
  • Journal Title: J Anesth. Volume: 28 Issue: 1 Pages: 19-25
  • DOI: 10.1007/s00540-013-1658-9
  • Peer Reviewed / Open Access
• [Journal Article] Recombinant Thrombomodulin Protects Mice against Histone-Induced Lethal Thromboembolism (2013)
  • Author(s): Nakahara M, Ito T, Kawahara KI, Yamamoto M, Nagasato T, Shrestha B, Yamada S, Miyauchi T, Higuchi K, Takenaka T, Yasuda T, Matsunaga A, Kakihana Y, Hashiguchi T, Kanmura Y, Maruyama I
  • Journal Title: PLoS One Volume: 30:8 Pages: 75961-75961
  • Peer Reviewed
• [Journal Article] Remifentanil temporarily improves renal function in adult patients with chronic kidney disease undergoing orthopedic surgery (2013)
  • Author(s): Terashi T, Takehara A, Kuniyoshi T, Matsunaga A, Kawasaki K, Kanmura Y
  • Journal Title: J Anesth Volume: 27 Pages: 340-5
  • Peer Reviewed
• [Journal Article] Increased carboxyhemoglobin level during liver resection with inflow occlusion (2013)
  • Author(s): Godai K, Hasegawa-Moriyama M, Kuniyoshi T, Matsunaga A, Kanmura Y
  • Journal Title: J Anesth Volume: 27 Pages: 306-8
  • Peer Reviewed
• [Journal Article] Increased carboxyhemoglobin level during liver resection with inflow occlusion. (2013)
  • Author(s): Godai K, Hasegawa-Moriyama M, Kuniyoshi T, Matsunaga A, Kanmura Y.
  • Journal Title: J Anesth. Volume: 27 Issue: 2 Pages: 306-308
  • DOI: 10.1007/s00540-012-1513-4
  • Peer Reviewed
• [Journal Article] Remifentanil temporarily improves renal function in adult patients with chronic kidney disease undergoing orthopedic surgery. (2013)
  • Author(s): Terashi T, Takehara A, Kuniyoshi T, Matsunaga A, Kawasaki K, Kanmura Y.
  • Journal Title: J Anesth Volume: 27 Issue: 3 Pages: 340-345
  • DOI: 10.1007/s00540-012-1545-9
  • Peer Reviewed
• [Journal Article] Recombinant thrombomodulin protects mice against histone-induced lethal thromboembolism. (2013)
  • Author(s): Nakahara M, Ito T, et al.
  • Journal Title: PLoS One Volume: 8(9) Issue: 9 Pages: 75961-75961
  • DOI: 10.1371/journal.pone.0075961
  • Peer Reviewed
• [Journal Article] Three cases of suspected sugammadex-induced hypersensitivity reactions (2012)
  • Author(s): Godai K, Hasegawa-Moriyama M, Kuniyoshi T, Kakoi T, Ikoma K, Isowaki S, Matsunaga A, Kanmura Y
  • Journal Title: British journal of Anesthesia Volume: 109 Issue: 2 Pages: 216-8
  • DOI: 10.1093/bja/aes137
  • Peer Reviewed
• [Journal Article] Effect of pneumoperitoneum on functional residual capacity (2012)
  • Author(s): Matsunaga A, Ohse K, Kakihana Y, Masuda M, Ikoma K, Kanmura Y
  • Journal Title: Advances in Experimental Medicine and Biology Volume: 737 Pages: 239-43
  • DOI: 10.1007/978-1-4614-1566-4_35
  • ISBN: 9781461415657, 9781461415664
  • Peer Reviewed
• [Journal Article] Cerebral monitoring using near-infrared time-resolved spectroscopy and postoperative cognitive dysfunction (2012)
  • Author(s): Kakihana Y, Okayama N, Matsunaga A, Yasuda T, Imabayashi T, Nakahara M, Kiyonaga N, Ikoma K, Kikuchi T, Kanmura Y, Oda M, Ohmae E, Suzuki T, Yamashita Y, Tamura M
  • Journal Title: Advances in Experimental Medicine and Biology Volume: 737 Pages: 19-24
  • DOI: 10.1007/978-1-4614-1566-4_3
  • ISBN: 9781461415657, 9781461415664
  • Peer Reviewed
• [Presentation] 多波長パルスオキシメータによるメトヘモグロビン血症患者モニタリング (2013)
  • Author(s): 松永明、磯脇純和、上村裕一
  • Organizer: 第35回日本手術医学会総会
  • Place of Presentation: 横浜
• [Presentation] 麻酔科領域におけるタブレットツールの応用 (2012)
  • Author(s): 松永明、磯脇純和、上村裕一
  • Organizer: 第34回日本手術医学会総会
  • Place of Presentation: 東京
• [Presentation] Effects of low-dose carperitide on hemodynamic stability in postoperative patients undergoing cardiovascular surgery (2012)
  • Author(s): T. Imabayashi, A. Matsunaga, M. Hasegawa, K. Ikoma, N. Kiyonaga, Y. Kanmura
  • Organizer: Euroanaesthesia
  • Place of Presentation: Paris, France
• [Presentation] Perfusion Index as a Predictive Factor of Postoperative Shivering (2012)
  • Author(s): A. Yoshikawa, M. Hasegawa-Moriyama, C. Kuroki, K. Godai, K. Enohata, A. Matsunaga, Y. Kanmura
  • Organizer: American Society of Anesthesiologists Annual Meeting
  • Place of Presentation: Washington, DC, United States
• [Presentation] Carboxyhemoglobin Level Reflects Hepatic Ischemia During Liver Resection With Inflow Occlusion (2012)
  • Author(s): K. Godai, M. Hasegawa-Moriyama, A. Yoshikawa, K. Enohata, A. Matsunaga, Y. Kanmura
  • Organizer: American Society of Anesthesiologists Annual Meeting
  • Place of Presentation: Washington, DC, United States
• [Book] 麻酔科医のための循環管理の実際 (2013)
  • Author(s): 松永 明、上村裕一
  • Total Pages: 307
  • Publisher: 中山書店