Gene therapy in cancer-induced bone pain using a blockade of brain derived neurotrophic factor
| Project/Area Number |
24659706
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MAESHIMA Kyoichiro 川崎医科大学, 麻酔・集中治療医学2, 講師 (20549852)
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| Research Collaborator |
ITANO Yoshitaro
TUGE Masatsugu
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 骨転移癌性疼痛モデル / 後根神経節 / ＢＤＮＦ / ＤＮＡデコイ / BDNF / NGF / DNAデコイ / 癌性疼痛 / 遺伝子治療 |
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| Outline of Final Research Achievements |
1. Brain-derived neurotrophic factor (BDNF) plays an important role in the pathological pain state in some pain models including bone cancer pain. Changes in BDNF in dorsal root ganglia (DRG) were studied in a rat bone cancer pain model. BDNF was increased in L3 DRG after intra-tibial inoculation of MRMT-1 rat breast cancer cells.
2. Decoy DNAs for BDNF exon1 not effective for pain relief derived from cancer. These results suggested that development of cancer pain were different mechanisms from neuropathic pain.
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Report
(4 results)
Research Products
(28 results)
