The international collaborating study of BIS monitoring system on rodents for the invention of new medicine

• Project/Area Number: 24659707
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Kurume University
• Principal Investigator: HARADA Hideki 久留米大学, 医学部, 准教授 (30198923)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: BISモニタリング / 齧歯類 / 脳健常性 / bispectral index / rat / 齧歯類BISモニタリング / Bispectral Index / ラット / 砂ネズミ

Outline of Final Research Achievements

We have invented special Bispectral Index monitoring device, capable attached on the scalps for the species such as rat or gerbil in case of of basic animal experiments. The device can reveal the clear EEG wave and BIS related values precisely from rats and gerbil, but not from mice. The data under inhaled anesthesia obtained from these rodents completely mimicked what those reported in human. For example, BIS value went down depending on the increasing of inhaled anesthetic concentration with sigmoid curve. With the device, BIS value could shortly follow cerebral ischemia or hypoxia caused by the experimental cerebral ischemia model in rats and gerbil.