The activation of injured testis by a novel system of using mesenchymal stem cell

• Project/Area Number: 24659711
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Jichi Medical University (2013-2014); Hamamatsu University School of Medicine (2012)
• Principal Investigator: TAKAYAMA TATSUYA 自治医科大学, 医学部, 准教授 (90324350)
• Co-Investigator(Kenkyū-buntansha): OZONO Seiichrou 浜松医科大学, 医学部, 教授 (00183228) ; TAKAOKA Naohisa 浜松医科大学, 医学部, 研究員 (30467229) ; TERATANI Takumi 自治医科大学, 医学部, 講師 (70373404)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 間葉系幹細胞 / 不妊症 / 再生医学

Outline of Final Research Achievements

Decline birth rate is national problem in Japan. It is also expected that male infertility comes to a settlement. We achieved the activation of injured testis in rat by the novel methods of using mesenchymal stem cell (MSC) which is one of stem cells derived from somatic cells. In this model, there was neither cell fusion nor tumoriogenicity. Sperm production was not derived from transfected MSC but host origin. Taking the application to human into consideration, we are now starting to try pig experiment.