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establishment of a new evaluation technique by none envasive MRI

Research Project

Project/Area Number 24659714
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Urology
Research InstitutionOsaka University

Principal Investigator

TAKAHARA Shiro  大阪大学, 医学(系)研究科(研究院), 寄附講座教授 (70179547)

Co-Investigator(Kenkyū-buntansha) KOBAYASHI Eiji  自治医科大学, 医学部, 研究員 (00245044)
KURODA Kagayaki  東海大学, 情報理工学部, 教授 (70205243)
ISAKA Yoshitaka  大阪大学, 大学院医学系研究科, 准教授 (00379166)
KAIMORI Jyun-ya  大阪大学, 大学院医学系研究科, 寄附講座准教授 (70527697)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsMRI / 臓器障害 / 移植グラフト / 腎移植 / 組織障害 / BOLD MRI / 拡散MRI / 拡散テンソルMRI / q space imaging / 移植腎繊維化
Outline of Final Research Achievements

The main objective of this study was to assess cardiac death (CD) kidney grafts before transplantation to determine whether blood oxygen level-dependent (BOLD) and diffusion MRI techniques can predict damage to these grafts after transplantation. We succeeded in evaluating cardiac death donor kidney graft tissue injury by detecting red blood cell accumulation and intra-cellular or outer-cellular edema with BOLD and diffusion MRI respectively. We assessed CD kidney tissue by BOLD and diffusion MRI. We showed that BOLD and diffusion MRI, which are readily available non-invasive tools for evaluating CD kidney grafts tissue damage, can predict prolonged organ damage, and therefore the outcome, of transplanted CD kidney grafts.(Kaimori J et.al, PlosOne 2013)

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (6 results)

All 2014 2013

All Journal Article (2 results) (of which Open Access: 1 results,  Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] 心停止後ラット腎臓のfunctional MRIを用いた詳細な障害の評価と腎移植後グラフト予後予測可能性2014

    • Author(s)
      貝森淳哉、岩井聡美、小林英司、畑中雅喜、津田秀年、小尾佳嗣、奥見雅由、矢澤浩治、市丸直嗣、楽木宏美、野々村祝夫、猪阪善隆、高原史郎
    • Journal Title

      Organ Biology

      Volume: 21(2) Pages: 179-181

    • NAID

      130004715801

    • Related Report
      2014 Annual Research Report
    • Open Access
  • [Journal Article] Non-Invasive Magnetic Resonance Imaging in Rats for Prediction of the Fate of Grafted Kidneys from Cardiac Death Donors2013

    • Author(s)
      J Kaimori, S Iwai, M Hatanaka, T Teratani, Y Obi,H Tsuda, Y Isaka, T Yokawa, K Kuroda, N Ichimaru,MOkumi, K Yazawa, H Rakugi, N Nonomura, S Takahara, E Kobayashi
    • Journal Title

      PLOS ONE

      Volume: Volume 8 | Issue 5 |

    • NAID

      130004715801

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Non-invasive magnetic resonance imaging in rats for prediction of the fate of grafted kidneys from cardiac death donors2013

    • Author(s)
      貝森淳哉
    • Organizer
      アジア移植学会
    • Place of Presentation
      京都国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] 移植腎臓live imaging : functional MRIとmultiphoton microscopy 2つのmodality2013

    • Author(s)
      貝森淳哉
    • Organizer
      日本移植学会
    • Place of Presentation
      京都国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] Non-invasive magnetic resonance imaging in rats for prediction of the fate of grafted kidneys from cardiac death donors2013

    • Author(s)
      貝森淳哉
    • Organizer
      日本臓器保存生物医学会
    • Place of Presentation
      東京医科大学病院
    • Related Report
      2013 Research-status Report
  • [Presentation] Non-invasive magnetic resonance imaging in rats for prediction of the fate of grafted kidneys from cardiac death donors2013

    • Author(s)
      貝森淳哉
    • Organizer
      アメリカ腎臓学会
    • Place of Presentation
      Atlanta, GA, USA
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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