| Project/Area Number |
24659714
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Osaka University |
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Principal Investigator |
TAKAHARA Shiro 大阪大学, 医学(系)研究科(研究院), 寄附講座教授 (70179547)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Eiji 自治医科大学, 医学部, 研究員 (00245044)
KURODA Kagayaki 東海大学, 情報理工学部, 教授 (70205243)
ISAKA Yoshitaka 大阪大学, 大学院医学系研究科, 准教授 (00379166)
KAIMORI Jyun-ya 大阪大学, 大学院医学系研究科, 寄附講座准教授 (70527697)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | MRI / 臓器障害 / 移植グラフト / 腎移植 / 組織障害 / BOLD MRI / 拡散MRI / 拡散テンソルMRI / q space imaging / 移植腎繊維化 |
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| Outline of Final Research Achievements |
The main objective of this study was to assess cardiac death (CD) kidney grafts before transplantation to determine whether blood oxygen level-dependent (BOLD) and diffusion MRI techniques can predict damage to these grafts after transplantation. We succeeded in evaluating cardiac death donor kidney graft tissue injury by detecting red blood cell accumulation and intra-cellular or outer-cellular edema with BOLD and diffusion MRI respectively. We assessed CD kidney tissue by BOLD and diffusion MRI. We showed that BOLD and diffusion MRI, which are readily available non-invasive tools for evaluating CD kidney grafts tissue damage, can predict prolonged organ damage, and therefore the outcome, of transplanted CD kidney grafts.（Kaimori J et.al, PlosOne 2013）
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