• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Functional analysis of the Y chromosome in the XY body formation of male meiotic

Research Project

Project/Area Number 24659715
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionThe University of Tokushima

Principal Investigator

SAKARI Matomo  徳島大学, ヘルスバイオサイエンス研究部, 特任助教 (90466772)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsY染色体 / スプライシング
Research Abstract

This study was conducted toward the elucidation of meiotic control mechanism via RNA splicing. 1)I was searching for a group of heterogeneous nuclear RNA is an mRNA precursor attempts to get meiosis-specific, the XY body-specific splicing target hnRNA, binds to Rbmy.To perform a detailed examination of conditions RNA-protein co-immunoprecipitation method using Rbmy in spermatogonia-derived cell lines NEC14, were successfully identified some of hnRNA Rbmy join group.2)
Attempts to produce the shRNA expression knockdown mice targeting Rbmy, was investigated conditions at the cellular level by building a knock-down vector.It was constructed in the vector to be controlled by the pol II to control knockdown tissue-specific manner.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (14 results)

All 2013 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (12 results)

  • [Journal Article] Androgen receptor promotes sex-independent angiogenesis in response to ischemia and is required for activation of vascular endothelial growth factor receptor signaling2013

    • Author(s)
      Yoshida S, Aihara K, Ikeda Y, Sumitomo-Ueda Y, Uemoto R, Ishikawa K, Ise T, Yagi S, Iwase T, Mouri Y, Sakari M, Matsumoto T, Takeyama K, Akaike M, Matsumoto M, Sata M, Walsh K, Kato S, Matsumoto T.
    • Journal Title

      Circulation

      Volume: 128 Issue: 1 Pages: 60-71

    • DOI

      10.1161/circulationaha.113.001533

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The androgen receptor in health and disease2013

    • Author(s)
      Matsumoto T, Sakari M, Okada M, Yokoyama A, Takahashi S, Kouzmenko A, Kato S
    • Journal Title

      Annu Rev Physiol

      Volume: vol. 75 Issue: 1 Pages: 201-224

    • DOI

      10.1146/annurev-physiol-030212-183656

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Y染色体遺伝子CDYのアンドロゲンシグナルを介した雄性特異的エピゲノム制御2013

    • Author(s)
      盛真友
    • Organizer
      第32回アンドロロジー学会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2013-07-26
    • Related Report
      2013 Final Research Report
  • [Presentation] Y染色体遺伝子CDYのアンドロゲンシグナルを介した雄性特異的エピゲノム制御2013

    • Author(s)
      盛真友
    • Organizer
      第32回 日本アンドロロジー学会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒトY染色体精子形成不全領域遺伝子RBMYのエストロゲンシグナルを介したスプライシング制御2012

    • Author(s)
      盛真友
    • Organizer
      第20回ステロイドホルモン学会
    • Place of Presentation
      石川県立音楽堂(石川県)
    • Year and Date
      2012-11-18
    • Related Report
      2013 Final Research Report
  • [Presentation] Y Chromosomal Azoospermic Factor RBMY and Estrogen Signaling Coordinately Regulate Male-specific Alternative Splicing2012

    • Author(s)
      盛真友
    • Organizer
      15^<th> ICHSHC
    • Place of Presentation
      石川県立音楽堂(石川県)
    • Year and Date
      2012-11-17
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒトY染色体精子形成不全領域遺伝子RBMYの分子機能解析2012

    • Author(s)
      盛真友
    • Organizer
      The 58th/60th NIBB Conference"Germline-Specification, Sex, and StemCells-"
    • Place of Presentation
      Okazaki New Grand Hotel(愛知県)
    • Year and Date
      2012-07-19
    • Related Report
      2013 Final Research Report
  • [Presentation] Y染色体遺伝子群と性ホルモンとの相互作用解析2012

    • Author(s)
      盛真友
    • Organizer
      第31回日本アンドロロジー学会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県)
    • Year and Date
      2012-06-30
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒトY染色体精子形成不全領域遺伝子RBMYの分子機能解析2012

    • Author(s)
      盛真友
    • Organizer
      第85回日本内分泌学会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2012-04-20
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒトY染色体性形成不全領域遺伝子RBMYの分子機能解析2012

    • Author(s)
      盛真友
    • Organizer
      第85回日本内分泌学会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2012 Research-status Report
  • [Presentation] Y染色体遺伝子群と性ホルモンとの相互作用解析2012

    • Author(s)
      盛真友
    • Organizer
      第31回日本アンドロロジー学会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県)
    • Related Report
      2012 Research-status Report
  • [Presentation] Y chromosomal azoospermic factor RBMY and estrogen signaling coordinately regulate male-specific alternative splicing2012

    • Author(s)
      盛真友
    • Organizer
      The58th/60th NIBB conference Germline
    • Place of Presentation
      Okazaki conference center(愛知県)
    • Related Report
      2012 Research-status Report
  • [Presentation] Y Chromosomal Azoospermic Factor RBMY and Estrogen Signaling Coordinately Regulate Male-specific Alternative Splicing2012

    • Author(s)
      盛真友
    • Organizer
      15th ICHSHC
    • Place of Presentation
      Ishikawa ongakudo(石川県)
    • Related Report
      2012 Research-status Report
  • [Presentation] ヒトY染色体精子形成不全領域遺伝子RBMYのエストロゲンシグナルを介したスプライシング制御2012

    • Author(s)
      盛真友
    • Organizer
      第20回ステロイドホルモン学会
    • Place of Presentation
      Ishikawa ongakudo(石川県)
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi