| Project/Area Number |
24659718
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Minoru 京都大学, 原子炉実験所, 准教授 (00319724)
INAMOTO Teruo 大阪医科大学, 医学部, 診療准教授 (20330087)
ONO Kouzi 京都大学, 原子炉実験所, 教授 (90122407)
MIYATAKE Shinichi 大阪医科大学, 医学部, 教授 (90209916)
UBAI Tkanobu 大阪医科大学, 医学部, 非常勤講師 (90388265)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 浸潤性膀胱癌 / 硼素中性子補足療法 / BNCT / 硼素 / 標的粒子線治療 / 硼素化合物 / 膀胱温存療法 / 加速器BNCT |
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| Research Abstract |
We have developed the following mouse models, 1) six different mouse bladder cancer models (T24, ACHN, UMUC3, OMC-BT1, OMC-BT2, OMC-BT3) and 2) mouse baloon occluded arterial infusion model. We have been working on producing the new Boron-10 delivery system, which can be accumulated selectively in the tumor cells, especially in bladder cancer cells, using several special techniques, such as coating technique with transferrin and polyethylene glycol, lyposome-delivery technique, and coating technique with antibodies, which has a special affinity to urothelical cancer antigen.
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