Novel bladder preservation therapy: BNCT-BOAI-Radiation, which selectively target cancer cells with very few complications

• Project/Area Number: 24659718
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: Osaka Medical College
• Principal Investigator: AZUMA Haruhito 大阪医科大学, 医学部, 教授 (40231914)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Minoru 京都大学, 原子炉実験所, 准教授 (00319724) ; INAMOTO Teruo 大阪医科大学, 医学部, 診療准教授 (20330087) ; ONO Kouzi 京都大学, 原子炉実験所, 教授 (90122407) ; MIYATAKE Shinichi 大阪医科大学, 医学部, 教授 (90209916) ; UBAI Tkanobu 大阪医科大学, 医学部, 非常勤講師 (90388265)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 浸潤性膀胱癌 / 硼素中性子補足療法 / BNCT / 硼素 / 標的粒子線治療 / 硼素化合物 / 膀胱温存療法 / 加速器BNCT

Research Abstract

We have developed the following mouse models, 1) six different mouse bladder cancer models (T24, ACHN, UMUC3, OMC-BT1, OMC-BT2, OMC-BT3) and 2) mouse baloon occluded arterial infusion model. We have been working on producing the new Boron-10 delivery system, which can be accumulated selectively in the tumor cells, especially in bladder cancer cells, using several special techniques, such as coating technique with transferrin and polyethylene glycol, lyposome-delivery technique, and coating technique with antibodies, which has a special affinity to urothelical cancer antigen.

Research Products

• [Journal Article] Initial Experience With Adaptive Iterative Dose Reduction 3D to Reduce Radiation Dose in Computed Tomographic Urography (2013)
  • Author(s): Juri H, Matsuki M, Itou Y, Inada Y, Nakai G,Azuma H, Narumi Y
  • Journal Title: J Comput Assist Tomogr Volume: 37(1) Pages: 52-57
• [Journal Article] Comparable effect with minimal morbidity of low-dose Tokyo 172 strain compared with regular dose Connaught strain as an intravesical bacillus Calmette-Guerin prophylaxis in nonmuscle invasive bladder cancer : Results of a randomized prospective comparison (2013)
  • Author(s): Teruo Inamoto, Takanobu Ubai, Takeshi Nishida, Yutaka Fujisue, Yoji Katsuoka, Haruhito Azuma
  • Journal Title: Urology Annals Volume: 5(1) Pages: 7-12
• [Journal Article] Effect of a novel bladder preservation therapy,BOAI-CDDP-radiation (OMC-regimen) (2013)
  • Author(s): Haruhito Azuma, Teruo Inamoto, Kiyoshi Takahara, Hayahito Nomi, Hiroshi Uehara, Kazumasa Komura, Koichiro Minami, Junko Kouno, Yatsugu Kotake , Hirokazu Abe, Shizuko Takagi, Kazuhiro Yamamoto, Yoshihumi Narumi, Satoshi Kiyama
  • Journal Title: INTERNATIONAL JOURNAL OF ONCOLOGY Volume: 243(1) Issue: 1 Pages: 79-87
  • DOI: 10.3892/ijo.2013.1923
• [Journal Article] A great option for elderly patients with locally invasive bladder cancer, BOAI-CDDP-radiation (OMC regimen) (2013)
  • Author(s): Haruhito Azuma, Teruo Inamoto , Kiyoshi Takahara, Hayahito Nomi, Hajime Hirano,Hiroshi Uehara, Kazumasa Komura, Koichiro Minami, Junko Kouno, Yat sugu Kotake, Hirokazu Abe, Shizuko Takagi, Naokazu Ibuki, Kazuhiro Yamamoto, Yoshihumi Narumi,Satoshi Kiyama
  • Journal Title: Int.Oncol Volume: 43 Issue: 4 Pages: 1087-1094
  • DOI: 10.3892/ijo.2013.2058
• [Journal Article] Post-operative urothelial recurrence in patients with upper urinary tract urothelial carcinoma managed by radical nephroureterectomy with an ipsilateral bladder cuff : Minimal prognostic impact in comparison with non-urothelial recurrence and other clinical indicators (2013)
  • Author(s): Takahara K, Inamoto T, Komura K, Watsuji T, Azuma H
  • Journal Title: Oncol Lett Volume: 6(4) Issue: 4 Pages: 1015-1020
  • DOI: 10.3892/ol.2013.1485
• [Journal Article] Adverse Event Profile and Dose Modification of Everolimus for Advanced Renal Cell Carcinoma in Real-world Japanese Clinical Practice (2013)
  • Author(s): Nozawa M, Nonomura N, Ueda T, Nishimura K, Kanayama HO, Miki T, Nakatani T, Tomita Y, Azuma H, Yoshioka T, Tsujihata M, Uemura H
  • Journal Title: Jpn J Clin Oncol Volume: 43(11) Issue: 11 Pages: 1132-8
  • DOI: 10.1093/jjco/hyt121
• [Journal Article] Single session of high-intensity focused ultrasound for localized prostate cancer : treatment outcomes and potential effect as a primary therapy (2013)
  • Author(s): Komura K, Inamoto T, Takai T, Uchimoto T, Saito K, Tanda N, Kono J, Minami K, Uehara H, Fujisue Y, Takahara K, Hirano H, Nomi H, Watsuji T, Kiyama S, Azuma H
  • Journal Title: World J Urol Volume: - Issue: 5 Pages: 1339-1345
  • DOI: 10.1007/s00345-013-1215-z
  • Peer Reviewed
• [Journal Article] Post-operative urothelial recurrence in patients with upper urinary tract urothelial carcinoma managed by radical nephroureterectomy with an ipsilateral bladder cuff: Minimal prognostic impact in comparison with non-urothelial recurrence and other clinical indicators.. (2013)
  • Author(s): Takahara K, Inamoto T, Komura K, Watsuji T, Azuma H.
  • Journal Title: Oncol Lett Volume: 6 Pages: 1015-1020
  • Peer Reviewed
• [Journal Article] A great option for elderly patients with locally invasive bladder cancer, BOAI-CDDP-radiation (OMC regimen). (2013)
  • Author(s): Azuma H, Inamoto T, Takahara K, Nomi H, Hirano H, Uehara H, Komura K, Minami K, Kouno J, Kotake Y, Abe H, Takagi S, Ibuki N, Yamamoto K, Narumi Y, Kiyama S.
  • Journal Title: Int J Oncol. Volume: 43 Pages: 1087-94
  • Peer Reviewed
• [Journal Article] Effect of a novel bladder preservation therapy, BOAI-CDDP-radiation (OMC-regimen). (2013)
  • Author(s): Azuma H, Inamoto T, Takahara K, Nomi H, Uehara H, Komura K, Minami K, Kouno J, Kotake Y, Abe H, Takagi S, Yamamoto K, Narumi Y, Kiyama S.
  • Journal Title: Int J Oncol. Volume: 43 Pages: 79-87
  • Peer Reviewed
• [Journal Article] Comparable effect with minimal morbidity of low-dose Tokyo 172 strain compared with regular dose Connaught strain as an intravesical bacillus Calmette–Guérin prophylaxis in nonmuscle invasive bladder cancer: Results of a randomized prospective comparison. (2013)
  • Author(s): Teruo Inamoto, Takanobu Ubai, Takeshi Nishida, Yutaka Fujisue, Yoji Katsuoka, Haruhito Azuma.
  • Journal Title: Urology Annals Volume: 5 Pages: 7-12
  • Peer Reviewed
• [Journal Article] Initial Experience With Adaptive Iterative Dose Reduction 3D to Reduce Radiation Dose in Computed Tomographic Urography. (2013)
  • Author(s): Juri H, Matsuki M, Itou Y, Inada Y, Nakai G, Azuma H, Narumi Y.
  • Journal Title: J Comput Assist Tomogr Volume: 37 Issue: 1 Pages: 52-57
  • DOI: 10.1097/rct.0b013e3182742c0e
  • Peer Reviewed
• [Journal Article] STAT3 polymorphism can predict the response to interferon-α therapy in patients with metastatic renal cell carcinoma. (2013)
  • Author(s): Eto M, Kamba T, Miyake H, Fujisawa M, Kamai T, Uemura H, Tsukamoto T, Azuma H, Matsubara A, Nishimura K, Nakamura T, Ogawa O, Naito S; Japan Immunotherapy SNPs-Study Group for Kidney Cancer.
  • Journal Title: Eur Urol. Volume: 63 Issue: 4 Pages: 745-752
  • DOI: 10.1016/j.eururo.2012.09.052
  • Peer Reviewed
• [Journal Article] Experience with high-intensity focused ultrasound therapy for management of organ-confined prostate cancer: critical evaluation of oncologic outcomes. (2013)
  • Author(s): Kazumasa Komura,Teruo Inamoto, HiroshiMasuda, ToshikazuWatsuji, Haruhito Azuma
  • Journal Title: Acta BioMedica Volume: in press
  • Peer Reviewed
• [Journal Article] Specific body mass index cut-off value in relation to survival of patients with upper urinary tract urothelial carcinomas (2012)
  • Author(s): Teruo Inamoto, Kazumasa Komura, Toshikazu Watsuji, Haruhito Azuma
  • Journal Title: Int J Clin Oncol Volume: 17(3) Pages: 256-262
  • NAID: 10030951612
• [Journal Article] Predictors of Success for Stone Fragmentation and Stone-Free Rate After Extracorporeal Shockwave Lithotripsy in the Treatment of Upper Urinary Tract Stones (2012)
  • Author(s): Kiyoshi Takahara, Naokazu Ibuki, Teruo Inamoto, Hayahito Nomi, Takanobu Ubai, Haruhito Azuma
  • Journal Title: Urology Journal Volume: 9(3) Pages: 549-552
• [Journal Article] Experience with high-intensity focused ultrasound therapy for management of organ-confined prostate cancer : critical evaluation of oncologic outcomes (2012)
  • Author(s): Kazumasa Komura, Teruo Inamoto, HiroshiMasuda, ToshikazuWatsuji, Haruhito Azuma
  • Journal Title: Acta BioMedica Volume: 83(3) Pages: 186-196
• [Journal Article] Immunotherapy of Genitourinary Malignancies. (2012)
  • Author(s): Teruo Inamoto, Haruhito Azuma.
  • Journal Title: Journal of Oncology Volume: 10 Pages: 1155-1155
  • DOI: 10.1155/2012/397267
  • Peer Reviewed
• [Journal Article] Immunotherapy of Genitourinary Malignancies
  • Author(s): Teruo Inamoto, Haruhito Azuma
  • Journal Title: Journal of Oncology Volume: Volume 2012
• [Presentation] 浸潤性膀胱癌に対する新規膀胱温存療法の治療成績 (2013)
  • Author(s): 東 治人
  • Organizer: 第61回 TEUS （Tokyo Expert Urology Seminar)
  • Place of Presentation: 東京ドームホテル
  • Invited
• [Presentation] 放射線併用バルーン塞栓抗癌剤動注による膀胱温存療法の治療成績 (2013)
  • Author(s): 東 治人
  • Organizer: 第1回泌尿器科画像診断・治療技術研究会
  • Place of Presentation: ホテルグランヴィア京都
  • Invited
• [Presentation] 日常癌診療における私たちの工夫 (2013)
  • Author(s): 東 治人
  • Organizer: 第24回みなと泌尿器カンファレンス
  • Place of Presentation: 東京慈恵医科大学 西講堂(東京都）
  • Invited
• [Presentation] 泌尿器科癌診療の私たちの工夫 (2012)
  • Author(s): 東治人
  • Organizer: 第15回関西泌尿器科研究会
  • Place of Presentation: リーガロイヤルホテル(大阪)
  • Year and Date: 2012-07-07
• [Presentation] 尿路上皮癌の診断と治療 : 浸潤性膀胱癌 (2012)
  • Author(s): 東治人
  • Organizer: 第3回CT Urography研究会
  • Place of Presentation: ヒルトンプラザウエスト(大阪)
  • Year and Date: 2012-06-23
• [Presentation] 泌尿器癌診療における私たちの工夫 (2012)
  • Author(s): 東治人
  • Organizer: 第62回日本泌尿器科学会大分地方会イブニングセミナー
  • Place of Presentation: レンブラントホテル大分(大分)
  • Year and Date: 2012-06-02
• [Presentation] 泌尿器癌診療における私たちの工夫 (2012)
  • Author(s): 東 治人
  • Organizer: 第62回日本泌尿器科学会大分地方会
  • Place of Presentation: レンブラントホテル大分(大分県）
  • Invited
• [Presentation] 尿路上皮癌の診断と治療 (2012)
  • Author(s): 東 治人
  • Organizer: 第3回 CT Urography研究会
  • Place of Presentation: ヒルトンプラザウエスト大阪(大阪府）
  • Invited
• [Presentation] バルーン塞栓選択的膀胱癌動脈抗癌剤動注（BOAI:VP16+CDDP)によってCRを誘導された浸潤性（T３≧）膀胱小細胞癌の１例 (2012)
  • Author(s): 南 幸一郎、東 治人
  • Organizer: 第５回RUPカンファレンス
  • Place of Presentation: 大阪医科大学新講義実習棟(大阪府）
• [Book] 新「名医」の最新治療2013 (2012)
  • Author(s): 東 治人
  • Total Pages: 4
  • Publisher: 新潮社
• [Book] 泌尿器外科 (2012)
  • Author(s): 稲元輝生、東 治人
  • Total Pages: 6
  • Publisher: メジカルビュー社