Development of novel molecular targeting therapies for ectopic pregnancy using its model mice
| Project/Area Number |
24659722
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 異所性妊娠 / モデル動物 / 分子標的治療 / 薬物療法 / 絨毛異所性妊娠 / 絨毛 |
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| Outline of Final Research Achievements |
Although methotrexate has been widely used for medical treatment of ectopic pregnancy, the development of more effective medical treatment with less adverse effects is anticipated. In this study, we performed DNA microarray analyses to find cell signaling pathway important for growth of villous tissues. Using villous tissue explants and an animal model for ectopic pregnancy, we evaluated their potential as candidates for molecular targeting therapy. We could find 3 targets with high potentials for development of novel medical therapies for ectopic pregnancy.
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Report
(4 results)
Research Products
(67 results)
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[Journal Article] Hippo Signaling Disruption and Akt Stimulation of Ovarian Follicles for Infertility2013
Author(s)
Kawamura K, Cheng Y, Suzuki N, Deguchi M, Sato Y, TakaeS, Ho CH, Kawamura N, Tamura M, Hashimoto S, Sugishita Y, Morimoto Y, Hosoi Y, Yoshioka N, Ishizuka B, Hsueh AJ.
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Journal Title
Proc Nat Acad Sci USA
Volume: 110
Issue: 43
Pages: 17474-17479
DOI
Related Report
Peer Reviewed
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