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Development of novel molecular targeting therapies for ectopic pregnancy using its model mice

Research Project

Project/Area Number 24659722
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionSt. Marianna University School of Medicine

Principal Investigator

KAWAMURA Kazuhiro  聖マリアンナ医科大学, 医学部, 准教授 (10344756)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords異所性妊娠 / モデル動物 / 分子標的治療 / 薬物療法 / 絨毛異所性妊娠 / 絨毛
Outline of Final Research Achievements

Although methotrexate has been widely used for medical treatment of ectopic pregnancy, the development of more effective medical treatment with less adverse effects is anticipated. In this study, we performed DNA microarray analyses to find cell signaling pathway important for growth of villous tissues. Using villous tissue explants and an animal model for ectopic pregnancy, we evaluated their potential as candidates for molecular targeting therapy. We could find 3 targets with high potentials for development of novel medical therapies for ectopic pregnancy.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (67 results)

All 2014 2013 2012 Other

All Journal Article (19 results) (of which Peer Reviewed: 14 results) Presentation (40 results) (of which Invited: 32 results) Book (7 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Anovel infertility treatment based on the technology of follicle activation: IVA2014

    • Author(s)
      Kawamura K31102-1062014
    • Journal Title

      in vitro Activation. J Mammal Ova Res

      Volume: 31 Issue: 9-10 Pages: 102-106

    • DOI

      10.1016/j.lfs.2011.06.022

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腹腔鏡下手術併用による最新の生殖補助医療2014

    • Author(s)
      河村和弘
    • Journal Title

      産婦人科の実際

      Volume: 63 Pages: 19-24

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 未受精卵子凍結保存の現状2014

    • Author(s)
      河村和弘、杉下陽堂、鈴木直
    • Journal Title

      臨床婦人科産科

      Volume: 68 Pages: 812-816

    • NAID

      40020172298

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 休眠原始卵胞の人為的活性化による新たな不妊治療の開発2014

    • Author(s)
      河村和弘
    • Journal Title

      医学のあゆみ

      Volume: 250 Pages: 1045-1046

    • Related Report
      2014 Annual Research Report
  • [Journal Article] POIの卵子再生治療2014

    • Author(s)
      河村和弘
    • Journal Title

      臨床婦人科産科

      Volume: 68 Pages: 902-907

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Regulation of preimplantation embryo development in mice by FMS-like tyrosine kinase ligand2014

    • Author(s)
      Nishijima C, Kawamura K, Okamoto N, Sato Y, Kawamura N, Ishizuka B, Tanaka M, Suzuki N
    • Journal Title

      Journal of Mammalian Ova Research

      Volume: 31 Pages: 45-51

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of late-onset ovarian insufficiency after ovarian surgery2014

    • Author(s)
      Takae S, Kawamura K, SatoY, Nishijima C, Yoshioka N, Sugishita Y, Horage Y, Tanaka M, Ishizuka B, Suzuki N
    • Journal Title

      PLoS One

      Volume: 23 Issue: 5 Pages: 98174-98174

    • DOI

      10.1371/journal.pone.0098174

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful pregnancy after sacrectomy combined with chemotherapy and radiation for Ewing’s sarcoma: case report and literature review2014

    • Author(s)
      Kakogawa J,Nako T,Kawamura K,Nakamura S,Mochiduki A,Kanayama N,Tanaka M
    • Journal Title

      Journal of Pediatric and Adolescent Gynecology

      Volume: 10 Issue: 3 Pages: 1016-1016

    • DOI

      10.1016/j.jpag.2014.06.009

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oocyte-derived R-spondin2 promotes ovarian follicle development.2013

    • Author(s)
      Cheng Y, Kawamura K, Takae S, Deguchi M, Yang Q, Kuo C, Hsueh AJW
    • Journal Title

      FASEB J

      Volume: 27 Issue: 6 Pages: 2175-2184

    • DOI

      10.1096/fj.12-223412

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of maternal aging on expression of sirtuin genes in ovulated oocyte and cumulus cells.2013

    • Author(s)
      Okamoto N, Kawamura K, Kawamura N, Nishijima C, Ishizuka B, Suzuki N, Hirata K
    • Journal Title

      J Mamm Ova Res

      Volume: 30 Pages: 24-29

    • NAID

      10031166253

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hippo Signaling Disruption and Akt Stimulation of Ovarian Follicles for Infertility2013

    • Author(s)
      Kawamura K, Cheng Y, Suzuki N, Deguchi M, Sato Y, TakaeS, Ho CH, Kawamura N, Tamura M, Hashimoto S, Sugishita Y, Morimoto Y, Hosoi Y, Yoshioka N, Ishizuka B, Hsueh AJ.
    • Journal Title

      Proc Nat Acad Sci USA

      Volume: 110 Issue: 43 Pages: 17474-17479

    • DOI

      10.1073/pnas.1312830110

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Suppression of choriocarcinoma invasion and metastasis following blockade of BDNF/TrkB signaling.2013

    • Author(s)
      Kawamura K, Kawamura N, Okamoto N, Manabe M
    • Journal Title

      Cancer Med

      Volume: 2 Pages: 849-861

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Regulation of preimplantation embryo development in mice by FMS-like tyrosine kinase ligand.2013

    • Author(s)
      Nishijima C, Kawamura K, Okamoto N, Sato Y, Kawamura N, Ishizuka B, Tanaka M, Suzuki N
    • Journal Title

      J Mammal Ova Res

      Volume: 31 Pages: 45-51

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 卵子成熟抑制因子(oocyte maturation inhibitor; OMI)の同定とその機能解析 c-type naturiuretic peptide (CNP)による卵子成熟抑制と二次卵胞発育促進作用.2013

    • Author(s)
      河村和弘
    • Journal Title

      産婦人科の実際

      Volume: 62 Pages: 1405-1411

    • Related Report
      2013 Research-status Report
  • [Journal Article] C-type natriuretic peptide stimulates ovarian follicle development.2012

    • Author(s)
      Sato Y, Cheng Y, Kawamura K, Takae S, Hsueh AJ
    • Journal Title

      Mol Endocrinol

      Volume: 26 Issue: 7 Pages: 1158-1166

    • DOI

      10.1210/me.2012-1027

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intraovarian thrombin and activated protein C signaling system regulates steroidogenesis during the periovulatoryperiod2012

    • Author(s)
      Cheng Y, Kawamura K, Deguchi M, Takae S, Mulders SM, Hsueh AJ
    • Journal Title

      Mol Endocrinol

      Volume: 26 Issue: 2 Pages: 331-340

    • DOI

      10.1210/me.2011-1187

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Suppression of hydatidiform molar growth by inhibiting endogenous brain-derived neurotrophic factor/tyrosine kinase B signaling.2012

    • Author(s)
      Kawamura K, Kawamura N, Kawagoe Y, Kumagai J, Fujimoto T, Terada Y
    • Journal Title

      Endocrinology

      Volume: 153 Issue: 8 Pages: 3972-3981

    • DOI

      10.1210/en.2012-1167

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibition of Uterine Sarcoma Cell Growth theough Suppression of endogenous tyrosine Kinase B Signaling2012

    • Author(s)
      Makino K,Terada Y et al
    • Journal Title

      PLoS One

      Volume: 7(7) Issue: 7 Pages: e41049-e41049

    • DOI

      10.1371/journal.pone.0041049

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Promotion of human early embryonic development and blastocyst outgrowthg in vitro using autocrine/paracrine growth factors.2012

    • Author(s)
      Kawamura K, Chen Y, Shu Y, Cheng Y, Qiao J, Behr B, Pera RA, Hsueh AJ
    • Journal Title

      PLoS One

      Volume: 7 Issue: 11 Pages: e49328-e49328

    • DOI

      10.1371/journal.pone.0049328

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Hippoシグナルの抑制とAktシグナルの活性化による卵胞発育の誘起を基盤とする新たな不妊治療法の開発2014

    • Author(s)
      河村和弘
    • Organizer
      第68回聖マリアンナ医科大学医学会
    • Place of Presentation
      聖マリアンナ医科大学(神奈川県)
    • Year and Date
      2014-12-11 – 2014-12-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Development of new infertility treatment based on Akt stimulation and Hippo suppression in ovarian follicles2014

    • Author(s)
      Kawamura K
    • Organizer
      Young Sicentific meeting for Sexual Differentiation
    • Place of Presentation
      静岡県
    • Year and Date
      2014-12-09 – 2014-12-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 卵胞活性化による早発卵巣不全の新しい不妊治療2014

    • Author(s)
      河村和弘
    • Organizer
      第59回日本生殖医学会学術講演会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2014-12-04 – 2014-12-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Highlights in embryology & hot topics and predictors of ART outcomes2014

    • Author(s)
      Kawamura K
    • Organizer
      Global Fertility Academy
    • Place of Presentation
      東京都
    • Year and Date
      2014-12-04 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 早発卵巣不全の新たな治療戦略2014

    • Author(s)
      河村和弘
    • Organizer
      座間・綾瀬・海老名産婦人科医会
    • Place of Presentation
      神奈川県
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 早発卵巣不全の治療戦略—in vitro activation(IVA)の臨床応用—2014

    • Author(s)
      河村和弘
    • Organizer
      第25回平成不妊研究会
    • Place of Presentation
      東京都
    • Year and Date
      2014-11-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] New infertility treatments of patients with primary ovarian insufficiency (POI)2014

    • Author(s)
      Kawamura K
    • Organizer
      Ovarian Follicles from Basic Science to Clinical Application
    • Place of Presentation
      スタンフォード大学(アメリカ)
    • Year and Date
      2014-11-09
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] In vitro activation as a tool for treating infertility related to premature ovarian failure2014

    • Author(s)
      Kawamura K
    • Organizer
      The 7 th World Congress on Mild Approaches in Assisted Reproduction
    • Place of Presentation
      グレースホテル(オーストラリア・シドニー)
    • Year and Date
      2014-09-10 – 2014-09-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Ovarian Grafting Video2014

    • Author(s)
      Kawamura K
    • Organizer
      Lunch Workshop
    • Place of Presentation
      グレースホテル(オーストラリア・シドニー)
    • Year and Date
      2014-09-10 – 2014-09-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] POIによる不妊に対する新しい治療戦略2014

    • Author(s)
      河村和弘
    • Organizer
      産婦人科臨床懇話会 不妊治療2014
    • Place of Presentation
      神奈川県
    • Year and Date
      2014-08-16 – 2014-08-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 卵巣機能不全患者の新たな不妊治療法の開発2014

    • Author(s)
      河村和弘
    • Organizer
      第15回 富山県不妊治療研究会
    • Place of Presentation
      富山県
    • Year and Date
      2014-07-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ヒト卵子再生と卵胞完全体外培養による新たな不妊治療法の開発2014

    • Author(s)
      河村和弘
    • Organizer
      新学術領域研究 動物における配偶子産生システムの制御 第2回領域会議
    • Place of Presentation
      秋保温泉ホテルクレセント(宮城県)
    • Year and Date
      2014-06-02
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Successful pregnancies and a birth after in vitro activation (IVA) of ovarian follicles in patients with primary ovarian insufficiency2014

    • Author(s)
      Kawamura K
    • Organizer
      The 66 th Annual meeting of the Korean Society for Reproductive Medicine
    • Place of Presentation
      ソウル大学病院(韓国・ソウル)
    • Year and Date
      2014-05-31
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 早発卵巣不全患者のIVA (in vitro activation)による卵胞活性化—卵巣自家移植の臨床成績2014

    • Author(s)
      河村和弘
    • Organizer
      第66回日本産科婦人科学会学術講演会
    • Place of Presentation
      国際フォーラム(東京都)
    • Year and Date
      2014-04-18 – 2014-04-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] IVAを用いたPOIへの新たな不妊治療.2014

    • Author(s)
      河村和弘
    • Organizer
      第10回ART生涯研修コース
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 卵巣機能不全患者の新たな不妊治療法の開発2014

    • Author(s)
      河村和弘
    • Organizer
      広島生殖医療研究会
    • Place of Presentation
      広島
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 新規卵子由来因子R-spondin2による初期卵胞発育制御.2013

    • Author(s)
      河村和弘
    • Organizer
      第65回日本産科婦人科学会学術講演会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 卵胞活性化技術のトランスレーショナルリサーチ:早発卵巣機能不全に対する新たな不妊治療法の確立.2013

    • Author(s)
      河村和弘
    • Organizer
      New Insights of Molecular Genetics on Growth Disorders
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 婦人科癌治療と卵巣凍結保存による妊孕性温存.2013

    • Author(s)
      河村和弘
    • Organizer
      第54回日本婦人科腫瘍学会学術講演会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 卵胞活性化技術(IVA: in vitro activation)を用いた早発卵巣機能不全患者の新たな不妊治療法.2013

    • Author(s)
      河村和弘
    • Organizer
      第31回日本受精着床学会学術講演会
    • Place of Presentation
      大分
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] In vitro activation (IVA) as a Novel Infertility Treatment for Primary Ovarian Insufficiency.2013

    • Author(s)
      Kazuhiro Kawamura
    • Organizer
      第65回日本産科婦人科学会学術講演会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 早発卵巣機能不全の新しい治療法.2013

    • Author(s)
      河村和弘
    • Organizer
      第20回ホルモン療法を考える神奈川県医師会の会
    • Place of Presentation
      神奈川
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 早発卵巣不全の新たな不妊治療法の開発.2013

    • Author(s)
      河村和弘
    • Organizer
      第15回横浜ART研究会
    • Place of Presentation
      神奈川
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 早発卵巣不全患者の新たな不妊治療法の開発:IVA(in vitro activation)による卵胞活性化―卵巣自家移植.2013

    • Author(s)
      河村和弘
    • Organizer
      第31回東京生殖医療懇談会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 早発閉経の卵胞活性化に着目した新規不妊治療法の開発2013

    • Author(s)
      河村和弘
    • Organizer
      第44回アステラス病態代謝研究会研究報告会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 新規卵子由来因子R-spondin2による初期卵胞発育制御2013

    • Author(s)
      河村和弘、佐藤可野、岡本直樹、高江正道、石塚文平、鈴木直、田中守.
    • Organizer
      第58回日本生殖医学会学術講演会・総会
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report
  • [Presentation] 新規卵子由来因子R-spondin2による初期卵胞発育制御2013

    • Author(s)
      河村和弘、河村七美、佐藤可野、石塚文平、田中守、鈴木直
    • Organizer
      第18回日本生殖内分泌学会学術集会
    • Place of Presentation
      とうきょう
    • Related Report
      2013 Research-status Report
  • [Presentation] 卵子成熟抑制因子(oocyte maturation inhibitor; OMI)の同定とその機能解析:C-type natriuretic peptide (CNP) による卵子成熟抑制と2次卵胞発育促進作用

    • Author(s)
      河村和弘,白澤弘光,熊澤由紀代,熊谷仁,寺田幸弘
    • Organizer
      第64回日本産科婦人科学会学術講演会
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
  • [Presentation] 休眠原始卵胞の人為的活性化技術とその臨床応用

    • Author(s)
      河村和弘
    • Organizer
      第241回長崎産科婦人科学会、長崎産婦人科医会、総会・学術集会
    • Place of Presentation
      長崎
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 休眠原始卵胞の人為的活性化技術を応用した早発閉経患者の新たな不妊治療法の開発

    • Author(s)
      河村和弘
    • Organizer
      第19回セント・ルカセミナー
    • Place of Presentation
      大分
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 休眠原始卵胞の人為的活性化技術を応用した早発閉経患者の新たな不妊治療法の開発

    • Author(s)
      河村和弘
    • Organizer
      第133回東北連合産科婦人科学会総会・学術講演会
    • Place of Presentation
      秋田
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 最新の不妊・不育症の治療について

    • Author(s)
      河村和弘
    • Organizer
      川崎市看護協会
    • Place of Presentation
      神奈川
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 早発卵巣不全の新たな不妊治療法の開発

    • Author(s)
      河村和弘
    • Organizer
      SOPHIA ART GROUP研究会
    • Place of Presentation
      神奈川
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 早発卵巣不全の新たな不妊治療法の開発

    • Author(s)
      河村和弘
    • Organizer
      第17回勝川ART研究会
    • Place of Presentation
      愛知
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 最新の不妊・不育症の治療について

    • Author(s)
      河村和弘
    • Organizer
      第490回横浜市産婦人科医会月例研究会
    • Place of Presentation
      神奈川
    • Related Report
      2012 Research-status Report
  • [Presentation] 早発卵巣不全患者の卵子の再生:休眠原始卵胞の活性化による成熟卵子の産出

    • Author(s)
      河村和弘
    • Organizer
      第57回日本生殖医学会学術講演会・総会
    • Place of Presentation
      長崎
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 卵子成熟抑制因子(oocyte maturation inhibitor; OMI)の同定とその機能解析:C-type natriuretic peptide (CNP) による卵子成熟抑制と2次卵胞発育促進作用

    • Author(s)
      河村和弘
    • Organizer
      第57回日本生殖医学会学術講演会・総会
    • Place of Presentation
      長崎
    • Related Report
      2012 Research-status Report
  • [Presentation] ヒト初期卵胞発育制御とその臨床応用

    • Author(s)
      河村和弘
    • Organizer
      第5回 文部科学省科学研究費補助金 特定領域研究 生殖系列の世代サイクルとエピゲノムネットワーク 班会議シンポジウム
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] brain-derived neurotrophic factor (BDNF)/tyrosine kinase B (TrkB) signalingによる胞状奇胎の発育制御とその分子機構の解明

    • Author(s)
      河村 和弘、西島千絵、吉岡伸人、杉下陽堂、高江正道、洞下由記、石山めぐみ、石塚 文平、田中 守、鈴木 直
    • Organizer
      第17回生殖内分泌学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 卵子の老化?!妊娠に適齢期はある?―不妊症と不育症を取り巻く現状―

    • Author(s)
      河村和弘
    • Organizer
      川崎市民公開講座
    • Place of Presentation
      神奈川
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] Follicle and oocyte development dynamics. In Biology and pathology of the oocyte.2013

    • Author(s)
      Hsueh AJW, Kawamura K
    • Publisher
      Cambridge University Press
    • Related Report
      2013 Research-status Report
  • [Book] 第III章体外受精とエイジングへの対応 IVFのための排卵誘発法の工夫.2013

    • Author(s)
      河村和弘
    • Publisher
      医師薬出版株式会社
    • Related Report
      2013 Research-status Report
  • [Book] 卵巣の予備能. がん・生殖医療 妊孕性温存の診療.2013

    • Author(s)
      高江正道、河村和弘、石塚文平
    • Publisher
      医師薬出版株式会社
    • Related Report
      2013 Research-status Report
  • [Book] 卵巣組織凍結. がん・生殖医療 妊孕性温存の診療.2013

    • Author(s)
      橋本周、鈴木直、河村和弘、杉下陽堂、森本義晴
    • Publisher
      医師薬出版株式会社
    • Related Report
      2013 Research-status Report
  • [Book] ASCO2013 最新トピックスー妊孕性温存に関する新ガイドライン概要.2013

    • Author(s)
      高江正道、西島千絵、吉岡伸人、杉下陽堂、洞下由紀、石山めぐみ、河村和弘、鈴木直
    • Publisher
      医師薬出版株式会社
    • Related Report
      2013 Research-status Report
  • [Book] 卵巣組織のガラス化保存法:Cryo Support (Cryo Kit Type M). 卵巣組織凍結・移植 新しい妊孕性温存療法の実践2013

    • Author(s)
      杉下陽堂、橋本周、星名真理子、川越雄太、吉岡伸人、高江正道、洞下由紀、五十嵐豪、津田千春、矢持隆行、竹之下誠、細井美彦、河村和弘、森本義晴、鈴木直
    • Publisher
      医師薬出版株式会社
    • Related Report
      2013 Research-status Report
  • [Book] IVA. 卵巣組織凍結・移植 新しい妊孕性温存療法の実践2013

    • Author(s)
      河村和弘
    • Publisher
      医師薬出版株式会社
    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] STIMULATION OF OVARIAN FOLLICLE DEVELOPMENT AND OOCYTEMATURATION2012

    • Inventor(s)
      Kazuhiro Kawamura, Aaron Hsueh
    • Industrial Property Rights Holder
      Kazuhiro Kawamura, Aaron Hsueh
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-09-12
    • Related Report
      2012 Research-status Report
    • Overseas

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Published: 2013-05-31   Modified: 2019-07-29  

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