Establishment and functional analysis of induced pluripotent cancer cells in ovarian cancer
Project/Area Number |
24659723
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Obstetrics and gynecology
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Research Institution | Yamagata University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Kazuhiro 山形大学, 医学部, 准教授 (20292427)
OHTA Tsuyoshi 山形大学, 医学部, 助教 (50375341)
SAWADA Kenjiro 大阪大学, 医学部, 講師 (00452392)
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 卵巣がん / 低酸素 / microRNA / ハニカム膜 / 細胞接着 / 細胞増殖 / 卵巣癌幹細胞 / 卵巣明細胞腺癌 / 卵巣癌 |
Research Abstract |
Honeycomb films (3D porous scaffold) exert an influence on cell adhesion and proliferation. Honeycomb films inhibited cell proliferation compared with control flat films in ovarian cancer cells, suggesting that honeycomb films have the possibility of inducing cancer cell to cancer stem cell and suppressing peritoneal spread of ovarian cancer. Ovarian cancer ascites were collected from patients who underwent surgery and we identified that primary CD11b+CD14+ cells, which were predominantly macrophages, are the major source of IL-6 production in an ovarian tumor microenvironment. When CD11b+CD14+ cells were co-cultured with cancer cells, the invasion and the proliferation of cancer cells were robustly promoted and these promotions were almost inhibited by the pretreatment of anti-IL-6R antibody (tocilizumab).
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Report
(3 results)
Research Products
(32 results)
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[Journal Article] Potential Role of mTORC2 as a Therapeutic Target in Clear Cell Carcinoma of the Ovary.2013
Author(s)
Hisamatsu T, Mabuchi S, Matsumoto Y, Kawano M, Sasano T, Takahashi R, Sawada K, Ito K, Kurachi H, Schilder RJ, Testa JR, Kimura T.
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Journal Title
Mol Cancer Ther.
Volume: 12
Issue: 7
Pages: 1367-77
DOI
Related Report
Peer Reviewed
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[Journal Article] Yolk Sac Tumor of the Ovary: A Retrospective Multicenter Study of 33 Japanese Women by Tohoku Gynecologic Cancer Unit (TGCU)2013
Author(s)
Kojimahara T, Nakahara K, Takano T, Yaegashi N, Nishiyama H, Fujimori K, Sato N, Terada Y, Tase T, Yokoyama Y, Mizunuma H, Shoji T, Sugiyama T, Kurachi H.
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Journal Title
The Tohoku Journal of Experimental Medicine
Volume: 230
Issue: 4
Pages: 211-217
DOI
NAID
ISSN
0040-8727, 1349-3329
Related Report
Peer Reviewed
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[Presentation] 卵管悪性腫瘍の臨床的解析 東北婦人科腫瘍研究会後方視的検討2012
Author(s)
横山良仁,二神真行,高取恵里子,杉山 徹,大槻健郎,八重樫伸生,藤本俊郎,寺田幸弘,佐藤直樹,小島原敬信,倉智博久,西山 浩,藤森敬也,田勢 亨,水沼英樹.
Organizer
第50回日本癌治療学会
Place of Presentation
パシフィコ横浜(横浜市)
Related Report
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