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Study of the expression and function of C2GnT1 in endometrial carcinoma

Research Project

Project/Area Number 24659724
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionShinshu University

Principal Investigator

SUZUKI Akihisa  信州大学, 医学部附属病院, 特任研究員 (10547095)

Co-Investigator(Kenkyū-buntansha) SHIOZAWA Tanri  信州大学, 医学部, 教授 (20235493)
MIYAMOTO Tsutomu  信州大学, 医学部付属病院, 講師 (70418721)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsC2GnT1 / 子宮内膜癌 / 予後因子 / コア 2 分枝糖鎖 / 糖転移酵素 / core2分枝 / シアル化ルイスX抗原
Research Abstract

Anti-human C2GnT1 rabbit polyclonal antibody were supplied from Prof. Nakayama
(Shinshu Univ. Molecular Pathology) and confirmed its specificity by western blotting and immunofluorescent staining using COS7 cells transfected human C2GnT1 cDNA. Using this anti-C2GnT1 antibody, the expression of C2GnT1 was examined in normal endometrium, atypical endometrial hyperplasia and endometrial carcinoma, immunohistochemically. The expression of C2GnT1 was significantly stronger in endometrial carcinoma than that in normal endometrium (P<0.05). In endometrial carcinomas, the stronger expression of C2GnT1 seemed to be involved in aggressiveness including higher histological grade, deep
myometrial invasion, and lymph-vascular space invasion. Kaplan-Meier method revealed that the cases with C2GnT1 overexpression were associated with shorter survival periods (P<0.05). In addition, multi-variable analysis revealed that C2GnT1 overexpression was an independent prognostic factor.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (19 results)

All 2013 2012

All Journal Article (8 results) (of which Peer Reviewed: 7 results) Presentation (11 results)

  • [Journal Article] Lipocalin2 enhances the matrix metalloproteinase-9 activity and invasion of extravillous trophoblasts under hypoxia2013

    • Author(s)
      Kobara H, Miyamoto T, Suzuki A, Asaka R, Yamada Y, Ishikawa K, Kikuchi N, Ohira S, Shiozawa T
    • Journal Title

      Placenta

      Volume: 34 Pages: 1036-43

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clonality analysis suggests that STK11 gene mutations are involved in progression of lobular endocervical glandular hyperplasia (LEGH) to minimal deviation adenocarcinoma (MDA)2013

    • Author(s)
      Takatsu A, Miyamoto T, Fuseya C, Suzuki A, Kashima H, Horiuchi A, Ishii K, Shiozawa T
    • Journal Title

      Virchows Arch

      Volume: 462 Pages: 645-51

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical expression of core 2β1,6-N-acetylglucosaminyl transferase 1 (C2GnT1) in endometrioid-type endometrial carcinoma : a novel potential prognostic factor2013

    • Author(s)
      Miyamoto T, Suzuki A, Asaka R, Ishikawa K, Yamada Y, Kobara H, Nakayama J, Shiozawa T
    • Journal Title

      Histopathology

      Volume: 62(7) Pages: 986-93

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical expression of core 2 β1,6-N-acetylglucosaminyl transferase 1 (C2GnT1) in endometrioid-type endometrial carcinoma: a novel potential prognostic factor.2013

    • Author(s)
      Miyamoto T
    • Journal Title

      Histopathology

      Volume: Feb 9 [Epub ahead of print] Issue: 7 Pages: 986-93

    • DOI

      10.1111/his.12107

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clonality analysis suggests that STK11 gene mutations are involved in progression of lobular endocervical glandular hyperplasia (LEGH) to minimal deviation adenocarcinoma (MDA).2013

    • Author(s)
      Takatsu A, Miyamoto T, Fuseya C, Suzuki A, Kashima H, Horiuchi A, Ishii K, Shiozawa T
    • Journal Title

      Virchows Arch

      Volume: 462(6) Issue: 6 Pages: 645-51

    • DOI

      10.1007/s00428-013-1417-1

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lipocalin2 enhances the matrix metalloproteinase-9 activity and invasion of extravillous trophoblasts under hypoxia.2013

    • Author(s)
      Kobara H, Miyamoto T, Suzuki A, Asaka R, Yamada Y, Ishikawa K, Kikuchi N, Ohira S, Shiozawa T.
    • Journal Title

      Placenta

      Volume: 34(11) Issue: 11 Pages: 1036-43

    • DOI

      10.1016/j.placenta.2013.08.004

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Involvement of pelvic inflammation-related mismatch repair abnormalities and microsatellite instability in the malignant transformation of ovarian endometriosis2012

    • Author(s)
      Fuseya C, Horiuchi A, Hayashi A, Suzuki A, Miyamoto T, Hayashi T, Shiozawa T
    • Journal Title

      Hum Pathol

      Volume: 43 Pages: 1964-72

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognostic significance of Notch signalling molecules and their involvement in the invasiveness of endometrial carcinoma cells2012

    • Author(s)
      Mitsuhashi Y, Horiuchi A, Miyamoto T, Kashima H, Suzuki A, Shiozawa T
    • Journal Title

      Histopathology

      Volume: 60 Pages: 826-37

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 子宮内膜癌におけるポリコーム遺伝子群発現とその臨床病理学的意義の検討2013

    • Author(s)
      石川香織、宮本強、鈴木昭久、山田靖、浅香亮一、塩沢丹里
    • Organizer
      第65回日本産科婦人科学会学術講演会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] レトロウイルスを用いたcDNA発現ライブラリーによる卵巣明細胞腺癌原因遺伝子の機能的スクリーニングの試み2013

    • Author(s)
      鈴木昭久、宮本強、内川順子、小原久典、山田靖、石川香織、塩沢丹里
    • Organizer
      第65回日本産科婦人科学会学術講演会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Sirtuin1(SIRT1),a longevity gene,is over-expressed in endometrial carcinoma2012

    • Author(s)
      Asaka R,Miymamoto T,Suzuki A,Ishikawa K,Yamada Y,Kobara H,Shiozawa T
    • Organizer
      14th International Gynecologic Cancer Society(IGCS)
    • Place of Presentation
      バンクーバー
    • Related Report
      2013 Final Research Report
  • [Presentation] The expression of lipocalin2 in ovarian carcinoma and endometriosis2012

    • Author(s)
      Y amada Y, Miyamoto T,Asaka R,Ishikawa k,Kobara H,Suzuki A,Shiozawa T
    • Organizer
      14th International Gynecologic Cancer Society(IGCS)
    • Place of Presentation
      バンクーバー
    • Related Report
      2013 Final Research Report
  • [Presentation] Lipocalin2 enhances the proliferation of endometrial carcinoma cells in nude mice2012

    • Author(s)
      Miyamoto T,Asaka R,Yamada Y,Ishikawa K,Kobara H,Suzuki A,Kashima H,Shiozawa T
    • Organizer
      14th International Gynecologic Cancer Society(IGCS)
    • Place of Presentation
      バンクーバー
    • Related Report
      2013 Final Research Report
  • [Presentation] 卵巣明細胞腺癌におけるレトロウイルスcDNAライブラリーを用いた機能的スクリーニングの試み2012

    • Author(s)
      鈴木昭久、宮本強、小原久典、山田靖、石川香織、浅香亮一、塩沢丹里
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 正常内膜および子宮内膜癌におけるSirtuin1(SIRT1)の発現と機能の検討2012

    • Author(s)
      浅香亮一、宮本強、石川香織、山田靖、小原久典、鈴木昭久、塩沢丹里
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] 子宮内膜癌におけるポリコーム遺伝子mRNA発現と臨床病理学的意義の検討2012

    • Author(s)
      石川香織、宮本強、鈴木昭久、山田靖、浅香亮一、塩沢丹里
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] Lipocalin2は子宮内膜症から発生する卵巣癌で高発現している2012

    • Author(s)
      山田靖、宮本強、浅香亮一、石川香織、小原久典、鈴木昭久、鹿島大靖、塩沢丹里
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] Lipocalin2はヌードマウスでの子宮内膜癌細胞の腫瘍増大を促進する2012

    • Author(s)
      宮本強、浅香亮一、山田靖、石川香織、小原久典、鈴木昭久、鹿島大靖、塩沢丹里
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] Lipocalin2は紫外線照射後およびシスプラチン処理後の子宮内膜癌細胞の生存を促進する2012

    • Author(s)
      宮本強、浅香亮一、鈴木昭久、鹿島大靖、塩沢丹里
    • Organizer
      第64回日本産科婦人科学会学術講演会
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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