Study of the expression of keratan sulfate in gynecological malignancies
| Project/Area Number |
24659725
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIYAMOTO Tsutomu 信州大学, 医学部付属病院, 講師 (70418721)
KASHIMA Hiroyasu 信州大学, 医学部, 助教 (70464089)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ケラタン硫酸 / 婦人科悪性腫瘍 / 子宮内膜症 / 鑑別診断 / 女性生殖管 / 異所性子宮内膜 / 子宮内膜癌 / 卵巣癌 / 診断マーカー |
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| Research Abstract |
The immunohistochemical staining using monoclonal antibody for keratan sulfate (KS) revealed that the expression of KS was observed in 96.2% (25/26 cases) of non-neoplastic epithelia in female genital tract including fallopian tube, ovarian inclusion cyst, endocervical gland, eutopic and ectopic endometrium. In contrast, the expression of KS was negligible in digestive organ (1/47 cases, 2.3%) and urinary tract (0/6 cases, 0%). In addition, the expression of KS was observed in 90.6% (29/32 cases) of carcinomas in female genital tract (endometrial, tubal and ovarian carcinoma), whereas observed in 0% (0/33 cases) of other carcinomas in abdominal cavity (digestive tract, liver, kidney and urinary tract). These findings suggest that the immunostaining for KS is useful to discriminate epithelia and carcinomas of female genital tract in abdominal cavity. On the other hand, KS-positive cases were present in breast, lung, thyroid, pancreatic cancer and malignant mesothelioma.
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Report
(3 results)
Research Products
(29 results)
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[Journal Article] Recurrent low-grade endometrial stromal sarcoma with intracaval and intracardiac tumor thrombus : diagnosis, treatment,and surgical management2014
Author(s)
Miyamoto T, Tachibana R, Kobara H, Takano T, Kato H, Shimizu A, Ohya A, Uehara T, Shiozawa T
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Journal Title
International Cancer Conference Journal
Volume: 3: Issue 1
Pages: 1-7
Related Report
Peer Reviewed
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