Induction of immune-tolerance by a novel human trophoblast-specific soluble factor, laeverin
| Project/Area Number |
24659730
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SATO Yukiyasu 京都大学, 医学研究科, 講師 (00508236)
HORIE Akihito 京都大学, 医学研究科, 助教 (30535836)
HATTORI Akira 京都大学, 薬学研究科, 准教授 (50300893)
ARAKI Yosihiko 順天堂大学, 医学研究科, 准教授 (70250933)
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| Project Period (FY) |
2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | ヒト絨毛外栄養膜細胞 / laeverin / 免疫寛容 / 胚シグナル |
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| Research Abstract |
During human placentation, extravillous trophoblast invades maternal endometrium and remodels spiral arteries. In this study, we examined the physiological roles of a novel human trophoblast-specific soluble factor, laeverin that we identified. We found that soluble-form laeverin induced differentiation of monocytes into dendritic cells and showed possible involvement of laeverin in induction of immune-tolerance in cooperation with HLA-G. These findings provide a new insight into the mechanisms for intrauterine human fetal development.
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Report
(2 results)
Research Products
(11 results)
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[Journal Article] Overexpression of TEX101, a potential novel cancer marker, in head and neck squamous cell.2013
Author(s)
Yoshitake H, Yokoi H, Ishikawa H, Maruyama M, Endo S, Nojima M, Yoshida K, Yoshikawa H, Suzuki F, Takamori K, Fujiwara H and Araki Y
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Journal Title
Cancer Biomark
Volume: 13
Pages: 141-8
Related Report
Peer Reviewed
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[Journal Article] Eph-ephrin A system regulates human choriocarcinoma-derived JEG-3 cell invasion2013
Author(s)
Fujiwara H, Nishioka Y, Matsumoto H, Suginami K, Horie A, Tani H, Matsumura N, Baba T, Sato Y, Araki Y, Konishi I
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Journal Title
Int J Gynecol Cancer
Volume: 23
Pages: 576-82
Related Report
Peer Reviewed
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[Journal Article] Overexpression of TEX101, a potential novel cancer marker, in head and neck squamous cell carcinoma2013
Author(s)
Yoshitake H, Yokoi H, Ishikawa H, Maruyama M, Endo S, Nojima M, Yoshida K, Yoshikawa H, Suzuki F, Takamori K, Fujiwara H, Araki Y
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Journal Title
Cancer Biomark
Volume: 12
Pages: 141-8
Related Report
Peer Reviewed
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