| Project/Area Number |
24659730
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SATO Yukiyasu 京都大学, 医学研究科, 講師 (00508236)
HORIE Akihito 京都大学, 医学研究科, 助教 (30535836)
HATTORI Akira 京都大学, 薬学研究科, 准教授 (50300893)
ARAKI Yosihiko 順天堂大学, 医学研究科, 准教授 (70250933)
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| Project Period (FY) |
2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | ヒト絨毛外栄養膜細胞 / laeverin / 免疫寛容 / 胚シグナル |
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| Research Abstract |
During human placentation, extravillous trophoblast invades maternal endometrium and remodels spiral arteries. In this study, we examined the physiological roles of a novel human trophoblast-specific soluble factor, laeverin that we identified. We found that soluble-form laeverin induced differentiation of monocytes into dendritic cells and showed possible involvement of laeverin in induction of immune-tolerance in cooperation with HLA-G. These findings provide a new insight into the mechanisms for intrauterine human fetal development.
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