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New evaluation of fetal oxidative stress: measurement of the umbilical cord blood dimethyl sulfate-induced ascorbyl free radical by an electron spin resonance method

Research Project

Project/Area Number 24659734
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionOita University

Principal Investigator

NISHIDA Yoshihiro  大分大学, 医学部, 准教授 (10336274)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords酸化ストレス / 胎児機能不全 / 臍帯 / Vitamin C / ESR / 分娩 / Vitamin C radical / Umbilical cord blood / Fetal stress / 胎児 / 電子スピン共鳴法 / 胎盤 / fetus / oxidative stress / umbilical cord
Outline of Final Research Achievements

Objective. The aim is to evaluate intrapartum fetal oxidative stress in real-time by umbilical cord blood dimethyl sulfate (DMSO)-induced ascorbyl free radical (AFR) measured by an electron spin resonance (ESR) method. Methods. 75 mothers delivering at gestational age after 37 weeks were recruited. Umbilical artery (UA) and venous (UV) cord blood gas analysis was performed. Serum levels of DMSO-induced AFR (AFR/DMSO) that reflect vitamin C concentrations, was measured by ESR spectroscopy. Results. Blood gas analysis showed no significant differences among the groups. UA-AFR/DMSO level of elective cesarean section(CS) group was significantly lower compared with spontaneous delivery group. Emergency CS group showed significantly lower levels of UA-AFR/DMSO compared with elective CS group. UV-AFR/DMSO levels had no significant difference among the groups. Conclusions. It is suggested that fetal cord blood AFR/DMSO is a sensitive marker to assess fetal oxidative stress during delivery.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (7 results)

All 2014 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (5 results)

  • [Journal Article] Telmisartan induces growth inhibition, DNA double-strand breaks and apoptosis in human endometrial cancer cells.2014

    • Author(s)
      Naoko Koyama, Yoshihiro Nishida, Terukazu Ishii, Toshie Yoshida, Yuichi Furukawa,Hisashi Narahara.
    • Journal Title

      PLoS ONE

      Volume: 9(3)

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] New evaluation of fetal oxidative stress:measurement of the umbilical cord blood dimethyl sulfate-induced ascorbyl free radical by an electron spin resonance method2012

    • Author(s)
      Yoshihiro Nishida, Shigekiyo Matsumoto, Takashi Noguchi, Hishashi Narahara
    • Journal Title

      J Maternal-Fetal Neo Med

      Volume: 25(1) Issue: 12 Pages: 2499-2502

    • DOI

      10.3109/14767058.2012.704448

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] ESR によるビタミンC ラジカル値からみた精子機能2014

    • Author(s)
      西田欣広、松本重清、原田枝美、山下由貴、古賀寛教、北野敬明、
    • Organizer
      第67回日本酸化ストレス学会
    • Place of Presentation
      同志社大学(京都府京都市)
    • Year and Date
      2014-09-04 – 2014-09-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 緊急帝王切開術における妊婦へのビタミンC投与が胎児酸化ストレスとApgar score に与える影響2014

    • Author(s)
      松本重清、古賀寛教、新宮千尋、小山淑正、内野哲哉、牧野剛典、
    • Organizer
      第67回日本酸化ストレス学会
    • Place of Presentation
      同志社大学(京都府京都市)
    • Year and Date
      2014-09-04 – 2014-09-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 胎児酸化ストレスにおけるmalondialdehydeとフリーラジカルとの関連および候補蛋白の抽出2012

    • Author(s)
      西田欣広、石井照和、吉良尚子、楢原久司
    • Organizer
      第64回日本産科婦人科学会学術講演会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2013 Research-status Report 2012 Research-status Report
  • [Presentation] Non-reassuring fetal statusにおける酸化ストレスの解析2012

    • Author(s)
      西田欣広、楢原久司
    • Organizer
      第12回日本抗加齢医学会総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Research-status Report 2012 Research-status Report
  • [Presentation] Non-reassuring fetal statusと診断された胎児の酸化ストレスマーカーの解析2012

    • Author(s)
      西田欣広、石井照和、吉良尚子、楢原久司
    • Organizer
      第48回日本周産期・新生児学会総会
    • Place of Presentation
      大宮ソニックシティ
    • Related Report
      2013 Research-status Report 2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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