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Identification of endometrial cancer stem cell markers

Research Project

Project/Area Number 24659736
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionKyushu University

Principal Investigator

KATO Kiyoko  九州大学, 医学(系)研究科(研究院), 教授 (10253527)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords子宮体癌 / 癌幹細胞 / バイオマーカー
Research Abstract

We analyzed the association with dbpC/contrin(dbpC) and the character of endometrial cancer stem cells .We designed and constructed a cytomegarovirus vector containing dbpC cDNA, and transfected it into Ishikawa(IK) cells, an endometrial cancer cell line. The expression of ALDH1 was increased in IK-dbpC cells, compared to mock cells,and the ratio of SP cells were more than 10-fold in IK-dbpC cells compared to mock cells . Downreguration of dbpC expression was remarkably reduced the ALDH1 expression and the rate of SP cells, compared to negative control. Microarray analysis showed that one of the cancer/testis antigens was up-regulated in IK-dbpC cells compared with mock cells.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (31 results)

All 2014 2013 2012 Other

All Journal Article (19 results) (of which Peer Reviewed: 9 results) Presentation (12 results) (of which Invited: 4 results)

  • [Journal Article] The inhibitory effect of salinomycin on the proliferation, migration and invasion of human endometrial cancer stem-like cells2013

    • Author(s)
      Kusunoki S, Kato K, Tabu K, Inagaki T, Okabe H, Kaneda H, Suga S, Terao Y, Taga T,Takeda S
    • Journal Title

      Gynecol Oncol

      Volume: 129(3) Pages: 598-605

    • Related Report
      2013 Final Research Report
  • [Journal Article] Ovarian transitional cell carcinoma represents a poorly differentiated form of high-gradeserous or endometrioid adenocarcinoma2013

    • Author(s)
      Takeuchi T, Ohishi Y, Imamura H, Aman M, Shida K, Kobayashi H, Kato K, Oda Y
    • Journal Title

      Am J Surg Pathol

      Volume: 37(7) Pages: 1091-1099

    • Related Report
      2013 Final Research Report
  • [Journal Article] Association of MDM2 SNP309 and TP53 Arg72Pro polymorphisms with risk of endometrial cancer2013

    • Author(s)
      Yoneda T, Kuboyama A, Kato K, Ohgami T, Okamoto K, Saito T, Wake N
    • Journal Title

      Oncol Rep

      Volume: 30(1) Pages: 25-34

    • Related Report
      2013 Final Research Report
  • [Journal Article] がん幹細胞を標的とする治療法の開発2013

    • Author(s)
      加藤聖子、楠木総司
    • Journal Title

      産婦人科の実際

      Volume: 62(3) Pages: 289-295

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Association of MDM2 SNP309 and TP53 Arg72Pro polymorphisms with risk of endometrial cancer.2013

    • Author(s)
      Yoneda T, Kuboyama A, Kato K, Ohgami T, Okamoto K, Saito T, Wake N.
    • Journal Title

      Oncol Rep.

      Volume: 30 Issue: 1 Pages: 25-34

    • DOI

      10.3892/or.2013.2432

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The inhibitory effect of salinomycin on the proliferation, migration and invasion of human endometrial cancer stem-like cells2013

    • Author(s)
      Kusunoki S
    • Journal Title

      Gynecol Oncol

      Volume: in press Issue: 3 Pages: 153-154

    • DOI

      10.1016/j.ygyno.2013.03.005

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ovarian transitional cell carcinoma represents a poorly differentiated form of high-gradeserous or endometrioid adenocarcinoma.2013

    • Author(s)
      Takeuchi T, Ohishi Y, Imamura H, Aman M, Shida K, Kobayashi H, Kato K, Oda Y
    • Journal Title

      Am J Surg Pathol.

      Volume: 37 Pages: 1091-1099

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The maternally expressed gene Tssc3 regulates the expression of Mash2 transcription factorin mouse trophoblast stem cells through thr Akt-Sp1 signaling pathway2012

    • Author(s)
      Takao T, Asanoma K, Tsunematsu R, Kato K, Wake N
    • Journal Title

      J Biol Chem

      Volume: 287(51) Pages: 42685-42694

    • Related Report
      2013 Final Research Report
  • [Journal Article] Side-population cells derived from non-tumorigenic rat endometrial cells are a candidate cell of origin for malignant endometrial tumors.2012

    • Author(s)
      Kato K, Kusunoki S, Inagaki T, Yusuf N, Suga S, Terao Y, Arima T, Tsukimori K,Takeda S.
    • Journal Title

      J Stem Cell Res Ther.

      Volume: 10 Issue: S1 Pages: 1-7

    • DOI

      10.4172/2157-7633.s7-003

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of transient TCDD exposure on immortalized human trophoblast-derived cell lines2012

    • Author(s)
      Fukushima K, Tsukimori K, Li D, Takao T, Morokuma S, Kato K, Seki H, Takeda S, Matsumura S, Wake N
    • Journal Title

      Hum Exp Toxicol

      Volume: 31(6) Pages: 550-556

    • Related Report
      2013 Final Research Report
  • [Journal Article] Stem Cells in Human Normal Endometrium And Endometrial Cancer Cells : Characterization of Side-Population Cells2012

    • Author(s)
      Kato K
    • Journal Title

      Kaohsiung Journal of Medical Sciences

      Volume: 28(2) Pages: 63-71

    • Related Report
      2013 Final Research Report
  • [Journal Article] Endometrial cancer stem cells : a new target for cancer therapy2012

    • Author(s)
      Kato K
    • Journal Title

      Anticancer Res

      Volume: 32(6) Pages: 2283-2293

    • Related Report
      2013 Final Research Report
  • [Journal Article] [子宮体癌の生物学的特性から診断、治療まで]癌遺伝子と癌幹細胞2012

    • Author(s)
      加藤聖子
    • Journal Title

      産科と婦人科

      Volume: 79(2) Pages: 203-208

    • Related Report
      2013 Final Research Report
  • [Journal Article] [婦人科悪性腫瘍の治療開発とそのシーズ]子宮体癌・癌幹細胞の関連分子を標的とした治療法の開発2012

    • Author(s)
      加藤聖子
    • Journal Title

      産婦人科の実際

      Volume: 61(2) Pages: 235-243

    • Related Report
      2013 Final Research Report
  • [Journal Article] Effect of transient TCDD exposure on immortalized human trophoblast-derived cell lines.2012

    • Author(s)
      Fukushima K, Tsukimori K, Li D, Takao T, Morokuma S, Kato K, Seki H, Takeda S, MatsumuraS,Wake N
    • Journal Title

      Hum Exp Toxicol.

      Volume: 31 Pages: 550-556

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The maternally expressed gene Tssc3 regulates the expression of Mash2 transcription factor in mouse trophoblast stem cells through thr Akt-Sp1 signaling pathway.2012

    • Author(s)
      Takao T,Asanoma K,Tsunematsu R,Kato K,Wake N
    • Journal Title

      J Biol Chem

      Volume: 287 Pages: 42685-42694

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Stem Cells in Human Normal Endometrium And Endometrial Cancer Cells: Characterization of Side-Population Cells.2012

    • Author(s)
      Kato K
    • Journal Title

      Kaohsiung Journal of Medical Sciences.

      Volume: 28 Pages: 63-71

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Endometrial cancer stem cells: a new target for cancer therapy.2012

    • Author(s)
      Kato K
    • Journal Title

      Anticancer Res.

      Volume: 32 Pages: 2283-2293

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] SPARC was overexpressed in human endometrial cancer stem-like cells and promoted migration activity

    • Author(s)
      Yusuf N, Inagaki T, Kusunoki S, Okabe H, Yamada I, Matsumoto A, Terao T, Takeda S, Kato K
    • Journal Title

      Gynecol Oncol

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Development of new cancer therapy by targeting endometrial cancer stem cells2014

    • Author(s)
      Kiyoko Kato
    • Organizer
      The 72^<nd> Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2014-10-03
    • Related Report
      2013 Final Research Report
  • [Presentation] 子宮体がん幹細胞の生物学的特性の解析2014

    • Author(s)
      加藤聖子
    • Organizer
      日本内分泌学会学術総会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-04-25
    • Related Report
      2013 Final Research Report
  • [Presentation] 子宮内膜、子宮体癌幹細胞の同定と生物学的特性の解析2013

    • Author(s)
      加藤聖子
    • Organizer
      日本内分泌学会九州地方会
    • Place of Presentation
      沖縄
    • Year and Date
      2013-08-24
    • Related Report
      2013 Final Research Report
  • [Presentation] 子宮体癌幹細胞の同定と新規治療法開発の試み2013

    • Author(s)
      加藤聖子
    • Organizer
      関東産科婦人科連合学会
    • Place of Presentation
      東京
    • Year and Date
      2013-06-16
    • Related Report
      2013 Final Research Report
  • [Presentation] The inhibitory effect of salinomycin on the proliferation, migration and invasion of human endometrial cancer stem-like cells.2013

    • Author(s)
      Soshi Kusunoki
    • Organizer
      第3回アジア国際婦人科腫瘍学会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 子宮体癌の癌幹細胞形質獲得機構における精巣特異的発現遺伝子dbpC_contrin の関与2012

    • Author(s)
      楠木総司 加藤聖子 木村美葵 須賀 新 金田容秀 寺尾泰久 竹田 省
    • Organizer
      第64回日本産科婦人科学会学術講演会
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
  • [Presentation] 細胞基質蛋白SPARC(secreted protein acidic and rich in cystein)は子宮体癌細胞の遊走能を亢進する2012

    • Author(s)
      ヌルスマングリユスプ 加藤聖子楠木総司 金田容秀 木村美葵 須賀 新 寺尾泰久
    • Organizer
      第64回日本産科婦人科学会学術講演会
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
  • [Presentation] 子宮体癌の癌幹細胞形質獲得機構における精巣特異的発現遺伝子dbpC_contrin の関与2012

    • Author(s)
      楠木総司 加藤聖子 木村美葵 須賀 新 金田容秀 寺尾泰久 竹田 省
    • Organizer
      第52回日本婦人科腫瘍学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 子宮体癌幹細胞の生物学的特性の解析と新規治療法開発

    • Author(s)
      加藤聖子
    • Organizer
      関東産科婦人科連合学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Development of new cancer therapy by targeting endometrial cancer stem cells

    • Author(s)
      Kiyoko Kato
    • Organizer
      日本癌学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 産婦人科における幹細胞研究

    • Author(s)
      加藤聖子
    • Organizer
      近畿産婦人科学会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 子宮内膜・体癌幹細胞の同定と生物学的特性も解析

    • Author(s)
      加藤聖子
    • Organizer
      日本内分泌学会九州地方会
    • Place of Presentation
      沖縄
    • Related Report
      2013 Annual Research Report
    • Invited

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Published: 2013-05-31   Modified: 2019-07-29  

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