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the research of the mutual relationship in the mouse auditory cortex using the reversible photo- inactivation

Research Project

Project/Area Number 24659746
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionNiigata University

Principal Investigator

TAKAHASHI Sugata  新潟大学, 医歯(薬)学総合研究科, 客員研究員 (10154824)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI KUNIYUKI  新潟大学, 医歯学系, 准教授 (40452057)
KUBOTA YAMATO  新潟大学, 医歯学系, 助教 (40547593)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords大脳聴覚野 / マウス / イメージング / 光抑制法 / 光抑制
Outline of Final Research Achievements

It is known that there are the functional columns in the brain with the different roles depending on the sites. A conventional study of local cortical function in animals could be only in invasive research such as electrical cauterization. We have improved our equipment to obtain the bilateral auditory cortex simultaneously and we have recorded the responses to various sounds in the mouse auditory cortex. And we have also research the relationship between bilateral auditory cortices with transcranial reversible photo-inactivation. As a result, we found the new areas which specifically respond to the frequency change direction of the frequency modulated sound, and the end of the sound in the mouse auditory cortex. We also found that the auditory responses were influenced by the inhibition of the opposite auditory cortex. We think that these results can contribute to further auditory cortex research.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (7 results)

All 2015 2013 Other

All Presentation (6 results) Remarks (1 results)

  • [Presentation] The cortical area located dorsally to auditory cortex involved in sound-shape association memory in mice2015

    • Author(s)
      Tatsuya Yamagishi , Hiroaki Tsukano , Hironori Baba, Yuusuke Honma , Shinsuke Ohshima, Yamato Kubota, Kuniyuki Takahashi, Ryuichi Hishida, Takeshi Yagi, Katsuei Shibuki , Sugata Takahashi
    • Organizer
      The 30th Politzer Society Meeting / the 1st World Congress of Otology
    • Place of Presentation
      朱鷺メッセ(新潟県、新潟市)
    • Year and Date
      2015-06-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] OFF responses produced by short-term depression of thalamic inputs to inhibitory neurons in the mouse auditory cortex2015

    • Author(s)
      Hironori Baba, Hiroaki Tsukano, Tatsuya Yamagishi, Yuusuke Honma, Shinsuke Ohshima, Yamato Kubota, Kuniyuki Takahashi, Ryuichi Hishida, Katsuei Shibuki, Sugata Takahashi
    • Organizer
      The 30th Politzer Society Meeting / the 1st World Congress of Otology
    • Place of Presentation
      朱鷺メッセ(新潟県、新潟市)
    • Year and Date
      2015-06-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Bilateral functional differences in the mouse auditory cortex using flavoprotein autofluorescence imaging2013

    • Author(s)
      高橋邦行、馬場洋徳、本間悠介、大島伸介、窪田和、高橋姿
    • Organizer
      2nd meeting of EA ORL-HNS and CE ORL-HNS
    • Place of Presentation
      ニース(フランス)
    • Related Report
      2013 Research-status Report
  • [Presentation] フラビン蛋白蛍光イメージングを用いた大脳聴覚野の研究

    • Author(s)
      高橋邦行, 窪田和, 大島伸介, 本間悠介, 馬場洋徳, 髙橋姿, 塚野浩明, 菱田竜一, 澁木克栄
    • Organizer
      第1回基礎・臨床研究交流会
    • Place of Presentation
      新潟市
    • Related Report
      2012 Research-status Report
  • [Presentation] 先行持続刺激により出現する マウス聴覚野の二相性応答パターン

    • Author(s)
      馬場 洋徳, 本間 悠介, 大島 伸介, 窪田 和, 高橋 邦行, 澁木克栄, 髙橋 姿
    • Organizer
      第57回日本聴覚医学会総会
    • Place of Presentation
      京都市
    • Related Report
      2012 Research-status Report
  • [Presentation] マウス聴覚野OFF応答のイメージング解析

    • Author(s)
      馬場洋徳, 本間悠介, 大島伸介, 窪田和, 高橋邦行, 澁木克栄, 髙橋姿
    • Organizer
      第11回側頭骨疾患研究会
    • Place of Presentation
      東京都
    • Related Report
      2012 Research-status Report
  • [Remarks] フラビン蛋白蛍光法を用いた聴覚野機能解析

    • URL

      http://www.med.niigata-u.ac.jp/oto/about/research/

    • Related Report
      2015 Annual Research Report 2014 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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