| Project/Area Number |
24659747
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kyoto University |
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Principal Investigator |
INAOKA Takatoshi 京都大学, 医学(系)研究科(研究院), 客員研究員 (10623548)
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| Co-Investigator(Kenkyū-buntansha) |
HIRAMI Harukazu 京都大学, 医学研究科, 助教 (10374167)
NAKAGAWA Takayuki 京都大学, 医学研究科, 講師 (50335270)
SAKAMOTO Tatsunori 京都大学, 医学研究科, 助教 (60425626)
YAMAMOTO Norio 京都大学, 医学研究科, 助教 (70378644)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 内耳再生 / ナノテクノロジー / めまい / 有毛細胞 |
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| Research Abstract |
The aim of the present study was to develop a model of the vestibular hair cell using piezoelectric materials. Effects of alterations in the thickness of piezoelectric membranes and fixation designs of piezoelectric membranes in a silicon frame on responsible frequencies were investigated in vitro. The results demonstrated the efficacy of continuous alterations in thickness of piezoelectric membranes for expansion of dynamic ranges for frequencies. Alterations in fixation designs of piezoelectric membranes in a silicon frame also affected responsible frequencies. However, responsible frequencies of a redesigned device were still too high comparing vestibular stimuli. We also examined biological responses of cochlear tissues after implantation of the device, which showed no significant inflammatory responses in the cochleae four weeks after implantation.
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