A new glaucoma surgery using regenerative medicine

• Project/Area Number: 24659758
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: University of Fukui
• Principal Investigator: INATANI Masaru 福井大学, 医学部, 教授 (40335245)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: トランスレーショナルリサーチ

Outline of Final Research Achievements

Trabeculectomy is the most common glaucoma surgery in the world. Our clinical studies revealed that eyes with prior ocular surgery resulted in poorer surgical success because of surgical scarring in their conjunctiva. Our further clinical study suggests that the design of conjunctival incision during trabeculectomy is a critical factor for improving the surgical success. The transplantation of the regenerated conjunctival epithelium improved the surgical success for trabeculectomy in rabbit eyes that were associated with surgical scaring.

Research Products

• [Journal Article] Limbus- versus fornix-based trabeculectomy for open-angle glaucoma eyes with prior ocular surgery: the collaborative bleb-related infection incidence and treatment study. (2015)
  • Author(s): Yokota S
  • Journal Title: Scientific Reports Volume: 5 Issue: 1 Pages: 9290-9290
  • DOI: 10.1038/srep09290
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The 5-year incidence of bleb-related infection and its risk factors following filtering surgeries with adjunctive mitomycin C (2014)
  • Author(s): Yamamoto T,et al
  • Journal Title: Collaborative Bleb-related Infection Incidence and Treatment Study 2 Ophthalmology Volume: 121(5) Issue: 5 Pages: 1001-1006
  • DOI: 10.1016/j.ophtha.2013.11.025
  • Peer Reviewed
• [Journal Article] Risk factors for hyphema after trabeculectomy with mitomycin C (2013)
  • Author(s): Kojima S, Inatani M, Shobayashi K, Haga, A, Inoue T, Tanihara H
  • Journal Title: Journal of Glaucoma Volume: (in press) Issue: 5 Pages: 307-311
  • DOI: 10.1097/ijg.0b013e3182741c85
  • Peer Reviewed
• [Journal Article] A prospective comparison between trabeculectomy with mitomycin C and phacotrabeculectomy with mitomycin C (2013)
  • Author(s): Ogata-Iwao M, Inatani M, Takihara Y, Inoue T, Iwao K, Tanihara H
  • Journal Title: Acta Ophthalmologica Volume: 91 Issue: 6 Pages: 500-501
  • DOI: 10.1111/aos.12133
  • Peer Reviewed
• [Journal Article] Study on prognostic factor in trabeculectomy with mitomycin C having history of previous glaucoma surgery (2013)
  • Author(s): Awai-Kasaoka N, Inoue T, Inatani M, Takihara Y, Ogata-Iwao M, Tanihara H
  • Journal Title: Japanese Journal of Ophthalmology Volume: 57 Issue: 6 Pages: 514-519
  • DOI: 10.1007/s10384-013-0257-5
  • Peer Reviewed
• [Journal Article] Japanese Phaco-Goniosynechialysis Multicenter Study Group. Long-term efficacy of goniosynechialysis combined with phacoemulsification for primary angle closure (2013)
  • Author(s): Kameda T, Inoue T, Inatani M, Tanihara H
  • Journal Title: Graefe's Archive for Clinical and Experimental Ophthalmology Volume: 251 Issue: 3 Pages: 825-830
  • DOI: 10.1007/s00417-012-2091-8
  • Peer Reviewed
• [Journal Article] Frequency and risk factors for neovascular glaucoma after vitrectomy in eyes with proliferative diabetic retinopathy (2013)
  • Author(s): Goto A, Inatani M, Inoue T, Awai-Kasaoka N, Takihara Y, Ito Y, Fukushima M, Tanihara H
  • Journal Title: Journal of Glaucoma Volume: 22 Issue: 7 Pages: 572-576
  • DOI: 10.1097/ijg.0b013e31824d514a
  • Peer Reviewed
• [Journal Article] Impact of phacoemulsification on failure of trabeculectomy with mitomycin C (2012)
  • Author(s): Awai-Kasaoka N, Inoue T, Takihara Y, Kawaguchi A, Inatani M, 7人5番目
  • Journal Title: J Cataract Refract Surg Volume: 38 Issue: 3 Pages: 419-424
  • DOI: 10.1016/j.jcrs.2011.09.035
  • NAID: 120005148223
  • Peer Reviewed
• [Journal Article] Prognostic risk factors for failure of trabeculectomy with mitomycin C after vitrectomy (2012)
  • Author(s): Inoue T, Inatani M, Takihara Y, Awai-Kasaoka N, Ogata-Iwao M, Tanihara H
  • Journal Title: Japanese Journal of Ophthalmology Volume: 56 Issue: 5 Pages: 1389-1397
  • DOI: 10.1007/s10384-012-0171-2
  • NAID: 10031039818
  • Peer Reviewed
• [Journal Article] Simultaneous increases in multiple proinflammatory cytokines in the aqueous humor of pseudophakic glaucomatous eyes (2012)
  • Author(s): Inoue T, Kawaji T, Inatani M, Kameda T, Yoshimura N, Tanihara H
  • Journal Title: Journal of Cataract and Refractive Surgery Volume: 38 Issue: 8 Pages: 1389-1397
  • DOI: 10.1016/j.jcrs.2012.04.028
  • Peer Reviewed
• [Journal Article] Elevated levels of monocyte chemoattractant protein-1 in the aqueous humor after phacoemulsification. (2012)
  • Author(s): Kawai M
  • Journal Title: Investigative Ophthalmology and Visual Science Volume: 53 Issue: 13 Pages: 7951-7960
  • DOI: 10.1167/iovs.12-10231
  • Peer Reviewed
• [Presentation] Comparison of limbus-based vs fornix-based trabeculectomy in surgical success for open-angle glaucoma eyes with prior ocular surgery: The Collaborative Bleb-related Infection Incidence and Treatment Study. (2014)
  • Author(s): Inatani M, Yokota S, Takihara Y
  • Organizer: The 2nd Asia-Pacific Glaucoma Congress
  • Place of Presentation: 香港コンベンションセンター（中国香港）
  • Year and Date: 2014-09-26 – 2014-09-28
• [Presentation] 緑内障手術における組織侵襲とその対策 (2014)
  • Author(s): 稲谷 大
  • Organizer: 第23回日本眼科学会総会
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
  • Year and Date: 2014-04-01 – 2014-04-06
• [Presentation] 緑内障インプラント手術 (2013)
  • Author(s): 稲谷 大
  • Organizer: 第67回日本臨床眼科学会
  • Place of Presentation: 横浜市 パシフィコ横浜
  • Invited
• [Presentation] Pseudophakic glaucoma, complicated glaucoma. (2012)
  • Author(s): Inatani M
  • Organizer: The 27th APAO Congress
  • Place of Presentation: 韓国釜山コンベンションセンター
  • Invited
• [Remarks] 福井大学眼科研究内容紹介
  • URL: http://ganka-fukuimed.jp/class/pages/kenkyu.html
• [Remarks] 福井大学眼科研究業績
  • URL: http://ganka-fukuimed.jp/class/pages/gyouseki.html
• [Remarks] 福井大学眼科研究内容紹介
  • URL: http://ganka-fukuimed.jp/class/pages/kenkyu.html
• [Remarks] 福井大学眼科研究業績
  • URL: http://ganka-fukuimed.jp/class/pages/gyouseki.html