Regeneration of retinal neuron using Muller cells in the infarction area
| Project/Area Number |
24659759
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
CHIBA Dai 信州大学, 医学部附属病院, 助教 (70467158)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 網膜 / 梗塞 / 前駆細胞 / ミュラー細胞 / 糖尿病網膜症 / 網膜神経線維 / 神経線維前駆細胞 / 糖尿病黄斑浮腫 / 網膜虚血 / グリア細胞 / GFAP |
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| Research Abstract |
To make infarction in the retina, we used two models.1) laser induced necrotic area. 2) Kimba mice, transgenic mice that overexpress vascular endothelial growth factor in the retina. We developed a method to detect these infarcted area with optical coherence tomography or fluorescein angiography. We attempted to establish a method to induce expression of neurobslastic markers such as Pax6 and nestin in regenerative Muller cells in the retinal infarction. The definite protocol has to be pursued in the further studies.
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Report
(3 results)
Research Products
(4 results)
