| Project/Area Number |
24659760
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Tottori University |
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Principal Investigator |
RYOKO ISHIKURA 鳥取大学, 医学部附属病院, 助教 (00335530)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAZAKI Dai 鳥取大学, 医学部附属病院, 講師 (30346358)
INOUE Yoshitsugu 鳥取大学, 医学部, 教授 (10213183)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 角膜内皮 |
|---|
| Research Abstract |
Transcriptome of human corneal endothelial cells after HSV-1 infection was characterized by interferon response and pattern recognition receptor response. TLR9 stimulated by CpG DNA or viral infection induced Indoleamine 2,3-deoxygenase 1 (IDO1), which contribute to activation of regulatory T cells, which dampens inflammatory responses of acquired immune system for protection of corneal endothelial cells. Receptor of Advanced glycosylation end products was also induced by viral infection, and was suggested to be involved in recognition of damage associated molecule by TLR9.
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