| Project/Area Number |
24659764
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Kyushu University |
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Principal Investigator |
ISHIBASHI Tatsuro 九州大学, 医学(系)研究科(研究院), 教授 (30150428)
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Yasuhiro 九州大学, 大学病院, 助教 (20380389)
村上 祐介 九州大学, 医学(系)研究科(研究院), 研究員 (50634995)
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| Co-Investigator(Renkei-kenkyūsha) |
MURAKAMI Yusuke 九州大学, 医学研究科, 研究員 (50634995)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 網膜色素変性 / レーザースペックルフローグラフィー / 黄斑部網脈絡膜循環 / 黄斑部感度 / ウノプロストン点眼液 / 黄斑部循環 / 視細胞保護 / 臨床 |
|---|
| Research Abstract |
In the present study, we investigated the macular blood flow using laser speckle flowgraphy (LSFG) in patients with retinitis pigmentosa (RP) and its correlation with visual function. Our data showed that macular blood flow was decreased to approximately 60% in RP patients compared with control subjects. Moreover, the decreased macular blood flow was associated with the reduction of macular visual sensitivity in RP patients.
We demonstrated topical unoprostone isopropyl might have a therapeutic efficacy, such as improvements of the macular sensitivity, in patients with RP. Surprisingly, the macular sensitivity was maintained not only in the treated eyes, but also in the fellow eyes. The change ratios of macular blood flow obtained from RP patient were significantly increased in both the treated and the fellow eyes. These results demonstrate that topical unoprostone might have a therapeutic efficacy as a consequence of the macular blood flow improvement.
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