Innate immunity in ocular pharmacology
| Project/Area Number |
24659765
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Kagoshima University |
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Principal Investigator |
SAKAMOTO Taiji 鹿児島大学, 医歯(薬)学総合研究科, 教授 (10235179)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 薬物治療 / 自然免疫 / 網膜 / 眼内薬物 / 抗VEGF / 網膜色素上皮 / PKC / bevacizumab / aflibercept / ranibizumab / 薬物送達 / 網膜剥離 / 細胞増殖 |
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| Outline of Final Research Achievements |
First, triamcinolone-associated sterile inflammation was studied. Granular materials including triamcinolone acetate was co-incubated wth retinal pigment epithelial cells or R28 retinal cells. As a result, inflammatory cytokines including interleukin-1 beta was significantly upregulated in a time and dose dependent mannter. Next, the effect of cell debris was studied. The histone H3 was added to these cells resulting in upregulation of inflammatory cytokines. Moreover, the excessive amount of histones induced apoptosis. Peculiarly, these negative effects were inhibited by vitreous body or hyaluronic acid. These phenomenon was mediated through toll-like receptors. Therefore, innate immunity supposedly plays a certain role in the pathology of retinal diseases.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Upregulation of non-β cell-derived vascular endothelial growth factor A increases small cluster of insulin-producing cells in the pancreas.2014
Author(s)
Takenouchi K, Shrestha B, Yamakuchi M, Yoshinaga N, Arimura N, Kawaguchi H, Nagasato T, Feil R, Kawahara K, Sakamoto T, Maruyama I, Hashiguchi T.
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Journal Title
Exp Clin Endocrinol & Diabetes
Volume: in press
Related Report
Peer Reviewed
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