| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
First, triamcinolone-associated sterile inflammation was studied. Granular materials including triamcinolone acetate was co-incubated wth retinal pigment epithelial cells or R28 retinal cells. As a result, inflammatory cytokines including interleukin-1 beta was significantly upregulated in a time and dose dependent mannter. Next, the effect of cell debris was studied. The histone H3 was added to these cells resulting in upregulation of inflammatory cytokines. Moreover, the excessive amount of histones induced apoptosis. Peculiarly, these negative effects were inhibited by vitreous body or hyaluronic acid. These phenomenon was mediated through toll-like receptors. Therefore, innate immunity supposedly plays a certain role in the pathology of retinal diseases.
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