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Innate immunity in ocular pharmacology

Research Project

Project/Area Number 24659765
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionKagoshima University

Principal Investigator

SAKAMOTO Taiji  鹿児島大学, 医歯(薬)学総合研究科, 教授 (10235179)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords薬物治療 / 自然免疫 / 網膜 / 眼内薬物 / 抗VEGF / 網膜色素上皮 / PKC / bevacizumab / aflibercept / ranibizumab / 薬物送達 / 網膜剥離 / 細胞増殖
Outline of Final Research Achievements

First, triamcinolone-associated sterile inflammation was studied. Granular materials including triamcinolone acetate was co-incubated wth retinal pigment epithelial cells or R28 retinal cells. As a result, inflammatory cytokines including interleukin-1 beta was significantly upregulated in a time and dose dependent mannter. Next, the effect of cell debris was studied. The histone H3 was added to these cells resulting in upregulation of inflammatory cytokines. Moreover, the excessive amount of histones induced apoptosis. Peculiarly, these negative effects were inhibited by vitreous body or hyaluronic acid. These phenomenon was mediated through toll-like receptors. Therefore, innate immunity supposedly plays a certain role in the pathology of retinal diseases.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report

Research Products

(31 results)

All 2015 2014 2013 2012

All Journal Article (18 results) (of which Peer Reviewed: 18 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (10 results) (of which Invited: 10 results) Book (3 results)

  • [Journal Article] PENETRATION OF BEVACIZUMAB AND RANIBIZUMAB THROUGH RETINAL PIGMENT EPITHELIAL LAYER IN VITRO.2015

    • Author(s)
      Terasaki H, Sakamoto T, Shirasawa M, Yoshihara N, Otsuka H, Sonoda S, Hisatomi T, Ishibashi T.
    • Journal Title

      Retina

      Volume: 35

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Luminal and stromal areas of choroid determined by binarization method of optical coherence tomographic images.2015

    • Author(s)
      Sonoda S, Sakamoto T, Yamashita T, Uchino E, Kawano H, Yoshihara N, Terasaki H, Shirasawa M, Tomita M, Ishibashi T
    • Journal Title

      American Journal of Ophthalmology

      Volume: NA Pages: 1123-1131

    • DOI

      10.1016/j.ajo.2015.03.005

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Objective determination of optimal number of spectral-domain optical coherence tomographic images of retina to average.2014

    • Author(s)
      Shirasawa M, Sakamoto T, Terasaki H, Yamashita T, Uchino E, Sonoda S.
    • Journal Title

      Plos One

      Volume: 9

    • DOI

      10.1371/journal.pone.0110550

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hyaluronan protection of corneal endothelial cells against extracellular histones after phacoemulsification.2014

    • Author(s)
      Kawano H, Sakamoto T, Ito T, Miyata K, Hashiguchi T, Maruyama I.
    • Journal Title

      J Cataract Refract Surg.

      Volume: 40 Pages: 704-711

    • DOI

      10.1016/j.jcrs.2014.07.026

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Posterior pole asymmetry analyses of retinal thickness of upper and lower sectors and their association with peak retinal nerve fiber layer thickness in healthy young eyes.2014

    • Author(s)
      Yamashita T, Sakamoto T, Kakiuchi N, Tanaka M, Kii Y, Nakao K.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 55 Pages: 5673-8

    • DOI

      10.1167/iovs.13-13828

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between supernormal sectors of retinal nerve fibre layer and axial length in normal eyes.2014

    • Author(s)
      Yamashita T, Kii Y, Tanaka M, Yoshinaga W, Yamashita T, Nakao K, Sakamoto T.
    • Journal Title

      Acta Ophthalmol.

      Volume: 92

    • DOI

      10.1111/aos.12382

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Toxic effects of extracellular histones and their neutralization by vitreous in retinal detachment.2014

    • Author(s)
      Kawano H, Ito T, Yamada S, Hashiguchi T, Maruyama I, Hisatomi T, Nakamura M, Sakamoto T.
    • Journal Title

      Lab Invest.

      Volume: 94(5) Pages: 569-585

    • DOI

      10.1038/labinvest.2014.46

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Blood component and OCT reflectivity2014

    • Author(s)
      Sonoda S, Sakamoto T
    • Journal Title

      Curr Eye Res

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adhesiotomy with grafting of fat and perifascial areolar tissue for adhesions of extraocular muscles after trauma or surgery.2014

    • Author(s)
      Kamisasanuki T, Katori N, Kasai K, Hayashi K, Kokubo K, Ota Y, Sakamoto T.
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Upregulation of non-β cell-derived vascular endothelial growth factor A increases small cluster of insulin-producing cells in the pancreas.2014

    • Author(s)
      Takenouchi K, Shrestha B, Yamakuchi M, Yoshinaga N, Arimura N, Kawaguchi H, Nagasato T, Feil R, Kawahara K, Sakamoto T, Maruyama I, Hashiguchi T.
    • Journal Title

      Exp Clin Endocrinol & Diabetes

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Long-term observation of the vitreomacular relationship in normal fellow eyes of patients with unilateral idiopathic macular holes.2014

    • Author(s)
      Otsuji F, Nakano T, Sakamoto T, Uemura A.
    • Journal Title

      Ohthalmologica

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between retinal thickness of 64 sectors in posterior pole determined by optical coherence tomography and axial length and body height.2013

    • Author(s)
      Yamashita T, Tanaka M, Kii Y, Nakao K, Sakamoto T
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 54 Pages: 7478-7482

    • DOI

      10.1167/iovs.13-12586

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Particle-induced endophthalmitis: possible mechanisms of sterile endophthalmitis after intravitreal triamcinolone.2013

    • Author(s)
      Otsuka H, Kawano H, Sonoda S, Nakamura M, Sakamoto T
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 54 Pages: 1758-1766

    • DOI

      10.1167/iovs.12-11247

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] TNF-α disrupts morphologic and functional barrier properties of polarized retinal pigment epithelium.2013

    • Author(s)
      Shirasawa M
    • Journal Title

      Exp Eye Res.

      Volume: 27 Pages: 59-69

    • DOI

      10.1016/j.exer.2013.02.012

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Early diagnosis of macular hole closure of a gas-filled eye with Watzke-Allen slit beam test and spectral domain optical coherence tomography.2012

    • Author(s)
      Yamakiri K , Sakamoto T.
    • Journal Title

      Retina

      Volume: 32(4) Pages: 767-772

    • DOI

      10.1097/iae.0b013e318227aa1f

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Choroidal neovascularization of optic disk melanocytoma treated with bevacizumab.2012

    • Author(s)
      Kamissasanuki t, Uchino E, SakamotoT.
    • Journal Title

      Eur J Ophthalmol

      Volume: 22 (3) Pages: 503-505

    • DOI

      10.5301/ejo.5000060

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Optic disc swelling in Vogt-Koyanagi-Harada Disease.2012

    • Author(s)
      Nakao K, Abematsu N, MizushimaY, Sakamoto T.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 53 (4) Pages: 1917-1922

    • DOI

      10.1167/iovs.11-8984

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of foveal microstructure imaging with different spectral domain optical coherence tomography machines2012

    • Author(s)
      Terasaki H, Shirasawa M, Yamashita T, Yamashita T, Yamakiri K, Sonoda S, Sakamoto T
    • Journal Title

      Ophthalmology.

      Volume: 119(11) Pages: 2319-2327

    • DOI

      10.1016/j.ophtha.2012.07.012

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 網膜血管疾患の現状と問題2014

    • Author(s)
      坂本泰二
    • Organizer
      第37回東北ブロック眼科講習会
    • Place of Presentation
      秋田市秋田ビューホテル 飛翔I
    • Year and Date
      2014-08-31
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Softshell vitrectomy2014

    • Author(s)
      Sakamoto T
    • Organizer
      World Congress of Ophthalmology
    • Place of Presentation
      Tokyo International Forum, Tokyo
    • Year and Date
      2014-04-02 – 2014-04-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ye Drop for posterior eye,2014

    • Author(s)
      Sakamoto T
    • Organizer
      World Congress of Ophthalmology
    • Place of Presentation
      Tokyo International Forum, Tokyo
    • Year and Date
      2014-04-02 – 2014-04-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Emerging ne therapy for diabecic macular edema bsed upon OCT findings. Symposium diabetic retinopathy.2013

    • Author(s)
      Sakamoto T.
    • Organizer
      8th Asia pacific vitreoretinal society and 52nd JOVS annual meeting.
    • Place of Presentation
      Nagoya Congress Center, Nagoya, Japan,
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Current understanding of Retinal Vein Occlusion.2013

    • Author(s)
      Sakamoto T.
    • Organizer
      8th Asia pacific vitreoretinal society and 52nd JOVS annual meeting.
    • Place of Presentation
      Nagoya Congress Center, Nagoya, Japan,
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] When and How macular hole closes.2013

    • Author(s)
      Sakamoto T.
    • Organizer
      Vail Vitrectomy 2013
    • Place of Presentation
      Vail. Colorado, USA
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Biology of vitreous body2013

    • Author(s)
      Sakamoto T.
    • Organizer
      IVth Doheny Scholars Special Lecture
    • Place of Presentation
      Los Angeles, CA, USA
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Key note lectures. 3. No prone macular hole surgery.2012

    • Author(s)
      Sakamoto T.
    • Organizer
      XXI Vitreo Retina Society of India
    • Place of Presentation
      Guwahati, India
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Sterile endopthalmitis.2012

    • Author(s)
      Sakamoto T.
    • Organizer
      XXI Vitreo Retina Society of India
    • Place of Presentation
      Guwahati, India
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Particle-induced endophthalmitis.2012

    • Author(s)
      Sakamoto T.
    • Organizer
      43rd. The Retina Society.
    • Place of Presentation
      Washington DC, Washington DC
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] 今日の治療指針2015

    • Author(s)
      坂本泰二眼科責任編集(総編集 山口徹, 北原光夫, 福井次矢)
    • Total Pages
      1000
    • Publisher
      医学書院
    • Related Report
      2014 Annual Research Report
  • [Book] 専門医のための眼科診療クオリファイ212014

    • Author(s)
      坂本泰二編
    • Total Pages
      380
    • Publisher
      中山書店
    • Related Report
      2013 Research-status Report
  • [Book] 今日の治療指針2014年版2014

    • Author(s)
      坂本泰二
    • Total Pages
      2128
    • Publisher
      医学書院
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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