| Project/Area Number |
24659773
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatric surgery
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUDA Yasunobu 新潟大学, 医歯学系, 准教授 (40334669)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | mTOR / rapamycin / trachea / tracheal substitute / coil / tracheal defect / granulation / metallic |
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| Outline of Final Research Achievements |
In order to prevent a formation of granulation tissue around the original artificial trachea, made of super-elastic wire, mTOR signal system in the granulation tissue was examined using rabbit tracheal defect model. In granulation tissue, mTOR activity was increased up to 20―40 folds in comparison with tracheal epithelium. Application of rapamycin, which blocked the mTOR signal system, partially blocked the mTOR activation. At the same time, the granulation tissue changed into the pathological condition, which induced respiratory infection. We have examined the proper method of application of rapamycin and it was found that the application of rapamycin starting from the 2 weeks after operation induced the favorable results. It is also suggested that the natural healing process of the tracheal wall defect is compromised and obtaining an improvement in this healing process should be one of the treatment strategies for tracheal pathologies.
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