Effect of Botox on the hypertrophied bladder wall in fetal lambs
| Project/Area Number |
24659774
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatric surgery
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
NAGAE Hideki 聖マリアンナ医科大学, 医学部, 助教 (90468942)
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| Co-Investigator(Renkei-kenkyūsha) |
KITAGAWA Hiroaki 聖マリアンナ医科大学, 医学部, 教授 (80153097)
WAKISAKA Munechika 聖マリアンナ医科大学, 医学部, 准教授 (30267596)
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| Research Collaborator |
SEKI Yasuji 聖マリアンナ医科大学, 医学部, 講師 (20309462)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | Botulin Toxin / Fetal surgery / 胎児尿路閉塞 / ボツリヌス毒素 / 胎児治療 / プロテオミクス |
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| Research Abstract |
Posterior Urethral Valves (PUV) is a congenital anomaly almost entirely confined to boys. PUV often develop a specific bladder dysfunction that has become known as [PUV Bladder]. A recent development has been the use of Botulin Toxin (Botox) to treat bladder dysfunction, although this has not yet been tried in [Valve Bladder] patients. This study addresses the questions [will Botox modify the development of the hypertrophied fetal bladder?] and [what is the optimal dose of Botox in International Units/kg in the fetus?] We have shown that the placement of a non-valved shunt produces a hypertrophied bladder. This study is a pilot study to determine the feasibility of using Botox injected into the bladder wall to investigate whether the injection of Botox will improve the bladder development after the placement of a non-valved shunt and attempt to determine a possibly-effective dose.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Valved shunt as a treatment for obstructive uropathy : does pressure make a difference?2013
Author(s)
Hiroaki Kitagawa, Yasuji Seki, Hideki Nagae, Takeshi Aoba , Shutaro Manabe, Kei Ooyama , Junki Koike , Masayuki Takagi , Jane Zuccollo , Shinobu Tatsunami , Kevin C. Pringle
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Journal Title
Pediatr Surg Int
Volume: 29
Pages: 381-386
Related Report
Peer Reviewed
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