| Project/Area Number |
24659775
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Plastic surgery
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
SAITO Noriko 北海道大学, 医学(系)研究科(研究院), 客員研究員 (80374487)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Yuhei 北海道大学, 大学院医学研究科, 教授 (70271674)
FURUKAWA Hiroshi 北海道大学, 大学院医学研究科, 講師 (00399924)
OYAMA Akihiko 北海道大学, 大学院医学研究科, 講師 (70374486)
FUNAYAMA Megumi 北海道大学, 大学院医学研究科, 助教 (10533630)
SAITO Akira 北海道大学, 大学院医学研究科, 客員研究員 (70507574)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | リンパ浮腫 / リンパ節移植 / マウスモデル / 蛍光イメージング / 皮弁移植 |
|---|
| Research Abstract |
We developed the new lymph node transfer method using mouse hind limb model, in which we transferred the axillary lymph node to the popliteal space at the opposite side after the lymph node removal. Compared to control group, earlier improvement of lymphedema was observed in the lymph node transfer group.
We analyzed the mechanism of the improvement of lymphedema with the lymph node transfer, with fluorescence lymphatic imaging using indocyanine green and PDE system equipped with a charge-coupled device camera as a fluorescence detector. In the lymph node transfer group, formation of the collateral pathway and the transferred lymph node take were observed. This result supports the hypothesis that the lymph node transfer can improve lymphedema by increasing the lymphatic flow.
|
