| Project/Area Number |
24659776
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Plastic surgery
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| Research Institution | Hokkaido University |
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Principal Investigator |
SAITO Akira 北海道大学, 医学(系)研究科(研究院), 客員研究員 (70507574)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Yuhei 北海道大学, 大学院医学研究科, 教授 (70271674)
HURUKAWA Hiroshi 北海道大学, 大学院医学研究科, 講師 (00399924)
OYAMA Akihiko 北海道大学, 北海道大学病院, 講師 (70374486)
FUNAYAMA Emi 北海道大学, 大学院医学研究科, 助教 (10533630)
OSAWA Masayuki 北海道大学, 大学院医学研究科, 客員研究員 (70625029)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 顔面神経麻痺 / bFGF / 神経再生 / Axonal Guidance / 軸索誘導因子 / 神経突起 |
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| Research Abstract |
In the basic experiment using nine-week-old wistar male rat, when the main trunk of the facial nerve was cut and anastomosed by epineural suture, the nerve regeneration already started from the sutured edge at four week past from the operation, and the nerve could reached to the mimetic muscles. Furthermore, when it was attached bFGF-impregnated MedGel on the point of epineural suture, the speed of nerve regeneration was faster than former group. And finally it also improve the movement of the mimetic muscles. This will enable us to expect a good role and capacity of the control released bFGF in the treatment of facial palsy after neurotmesis.
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