Effects of estrogen and selective estrogen receptor modulators on normal and keloid fibroblasts
| Project/Area Number |
24659777
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Plastic surgery
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| Research Institution | Hokkaido University |
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Principal Investigator |
FURUKAWA Hiroshi 北海道大学, 医学(系)研究科(研究院), 講師 (00399924)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Yuhei 北海道大学, 大学院医学研究科, 教授 (70271674)
OYAMA Akihiko 北海道大学, 北海道大学病院, 講師 (70374486)
FUNAYAMA Emi 北海道大学, 大学院医学研究科, 助教 (10533630)
HAYASHI Toshiyuki 北海道大学, 大学院医学研究科, 准教授 (00432146)
HORIUCHI Katsumi 北海道大学, 大学院医学研究科, 客員研究員 (60625028)
SAITO Noriko 北海道大学, 大学院医学研究科, 客員研究員 (80374487)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 創傷治癒学 / ケロイド / 選択的エストロゲン受容体調節薬 |
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| Research Abstract |
Selective estrogen receptor modulators (SERMs) bind to estrogen receptors acting as an agonist or an antagonist depending on the target tissue. First, we detected the expression of estrogen receptors in keloid fibroblasts. Second, we investigated the effects of SERMs on keloid fibroblasts. The effect is different depending on the concentration of SERMs. Some SERMs are suggested to inhibit cell proliferation of keloid fibroblasts.
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Report
(3 results)
Research Products
(2 results)
