| Project/Area Number |
24659784
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Plastic surgery
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TERASHI Hiroto 神戸大学, 医学部附属病院, 教授 (80217421)
HASHIKAWA Kazunobu 神戸大学, 医学部附属病院, 准教授 (90403237)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | マイクロサージェリー学 / 血管生理学 / マイクロサージャリー / 塩酸リドカイン / 塩酸パパベリン / オルプリノン塩酸塩 / プロスタグランディンE1 / 血管拡張 / 血管攣縮 / ワイヤーミオグラフ |
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| Research Abstract |
To avoid the vascular spasm during microvascular surgery for free tissue transfer, lidocaine has been widely used. On the other hand, the proper concentration of lidocaine is unknown. We introduced wire-myograph system for pharmacological and physiological analysis of lidocaine or other substances for its anti-spasmogenic activity. We examined papaverine hydrochloride, phentolamine messmate, olprinone hydrochloride, nitroglycerine, and prostaglandin E1. On the result, those substances, except prostaglandin E1, showed concentration-dependent anti-spasmogenic activity. On the other hand, prostaglandin E1 showed concentration-dependent spasmogenic activity which may be caused by inflammatory activity. In conclusion, those substances may be used for anti-spasmogenic agent during microsurgical operation.
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