Interaction of hypoxia, and coagulation and inflammation through HIF-α.

• Project/Area Number: 24659793
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Emergency medicine
• Research Institution: Hokkaido University
• Principal Investigator: GANDO Satoshi 北海道大学, 大学院・医学研究科, 教授 (30125306)
• Co-Investigator(Kenkyū-buntansha): JESMIN Saubrina 国立国際医療センター研究所, 遺伝子診断治療開発研究部, 室長 (60374261)
• Co-Investigator(Renkei-kenkyūsha): WADA Takeshi 北海道大学, 大学病院, 助教 (30455646)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
• Keywords: 生体侵襲 / 臓器不全 / 凝固線溶系 / VEGF / Angiopoietin

Research Abstract

To test the hypothesis that Hypoxia-inducible factor1-α-induced angiogenetic factors (VEGF/VEGFR1/VEGFR2, angiopoietin and Tie2) deeply involved in the pathogenesis of organ dysfunction in patients with DIC associated with trauma, sepsis, and post cardiac arrest syndrome, we investigated the relationships of these factors and DIC. The results indicated that angiogenetic factors and DIC is one of the main causes of organ dysfunctionin patients with these three insults.

Research Products

• [Journal Article] Angiogenic factors and their soluble receptors for predicting organ dysfunction in disseminated intravascular coagulation associated with sepsis. (2013)
  • Author(s): Jesmin S
  • Journal Title: Inflammation Volume: 36 Issue: 1 Pages: 186-196
  • DOI: 10.1007/s10753-012-9534-6
  • Peer Reviewed / Open Access
• [Journal Article] Using angiogenic factors and their soluble receptors to predict organ dysfunction in patients with disseminated intravascular coagulation associated with severe trauma (2012)
  • Author(s): Wada T, Jesmin S, Gando S, SultanaSN, Zaedi S, Yokota H
  • Journal Title: Critical Care Volume: 16 Issue: 2
  • DOI: 10.1186/cc11309
  • Peer Reviewed
• [Journal Article] Time-dependent alterations of VEGF and its signaling molecules in acute lung injury in a rat model of sepsis (2012)
  • Author(s): Jesmin S, Zaedi S, Islam AM, SultanaSN, Iwashima Y, Wada T, Yamaguchi N, HiroeM, Gando S
  • Journal Title: Inflammation Volume: 35 Issue: 2 Pages: 484-500
  • DOI: 10.1007/s10753-011-9337-1
  • Peer Reviewed
• [Journal Article] Angiogenic factors and their soluble receptors predict organ dysfunction and mortality in post-cardiac arrest syndrome (PCAS) (2012)
  • Author(s): Wada T, Jesmin S, Gando S, Yanagida Y, Mizugaki A, Sultana SN, Zaedi S, Yokota H
  • Journal Title: Critical Care Volume: 16 Issue: 5
  • DOI: 10.1186/cc11648
  • Peer Reviewed
• [Presentation] Angiogenic factors and their soluble receptors for predicting organ dysfunction in disseminated intravascular coagulation associated with sepsis (2012)
  • Author(s): Wada T, Jesmin S, Yanagida Y, TerashimaT, Gando S
  • Organizer: 15^th WFSA World Conguress of Anaesthesiologists
  • Place of Presentation: Buenos Aires ConventionCenter, Argentina
• [Presentation] Angiogenic factors and their solube receptors to predict organ dysfunction in patients with DIC associated with severe trauma (2012)
  • Author(s): Wada T, Jesmin S, Gando S, Sultana SN, Zaedi S, Yokota H
  • Organizer: The 32^nd International Symposium on Intensive Care and Emergency Medicine
  • Place of Presentation: Brussel Meeting Center, Bergium
• [Presentation] Time dependent alterations of VEGF and its signal in molecules in acute lung injury in a rat model of sepsis (2011)
  • Author(s): Wada T, Jesmin S, Zaedi S, Gando S
  • Organizer: 24^rd European Society of Intensive Care Medicine Annual Congress
  • Place of Presentation: The International Congress Center Berlin, Germany.