Analysis of Functional Bowel Disorder and Development of Vew Treatments

• Project/Area Number: 24659805
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Emergency medicine
• Research Institution: Hyogo Medical University
• Principal Investigator: MAEYAMA YOSHIHIRO 兵庫医科大学, 医学部, 非常勤講師 (80614031)
• Co-Investigator(Kenkyū-buntansha): KIKUCHI Shojiro 兵庫医科大学, 医学部, 准教授 (70381960) ; ISHIKAWA Takehiko 北海道大学, 医学部, 講師 (70280849) ; OKAMURA Haruki 兵庫医科大学, 医学部, 特任教授 (60111043) ; KUBO Shuji 兵庫医科大学, 医学部, 准教授 (10441320)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 腸管機能不全 / CD56brightCD11c positive / γδT細胞 / 侵襲 / CD56brightCD11c+細胞

Research Abstract

We have analyzed CD56brightCD11c positive cells and gamma delta T cells on normal healthy donors and cancer patients. The number of CD56brightCD11c positive cells and gamma delta T cells from some cancer patients had already increased and did not have responses to ZOL and IL-18.

Research Products

• [Journal Article] Inhibition of CCL20 increases mortality in models of mouse sepsis with intestinal apoptosis (2013)
  • Author(s): Kitagawa Y, Kikuchi S, Arita Y, Nishimura M, Mizuno K, Ogasawara H, Kawano T, Ochiai T, Otsuji E, Imai T
  • Journal Title: Surgery Volume: 154(1) Pages: 78-88
  • DOI: 10.1016/j.surg.2013.02.012
  • Peer Reviewed
• [Journal Article] Inhibition of CCL20 increases mortality in models of mouse sepsis with intestinal apoptosis. (2013)
  • Author(s): Kitagawa Y1, Kikuchi S, Arita Y, Nishimura M, Mizuno K, Ogasawara H, Kawano T, Ochiai T, Otsuji E, Imai T.
  • Journal Title: Surgery Volume: 154(1) Pages: 78,88
  • DOI: 10.1016/j.surg.2013.02.012.
  • Peer Reviewed
• [Presentation] Cancer-Associated Fibroblasts Promote Migration of Gastric Cancer Cells (2013)
  • Author(s): Yoshihiro Maeyama
  • Organizer: 10th International Gastric Cancer Congress
  • Place of Presentation: Verona
  • Year and Date: 20130619-20130622
• [Presentation] Analysis of gamma delta T cell and its accessory cells in cancer patients (2013)
  • Author(s): 前山義博
  • Organizer: 日本分子生物学会
  • Place of Presentation: 神戸
  • Year and Date: 2013-12-03
• [Presentation] がん関連線維芽細胞が胃がん細胞の移動に与える影響の解析 (2013)
  • Author(s): 前山義博
  • Organizer: 日本癌学会
  • Place of Presentation: 札幌
  • Year and Date: 2013-10-05
• [Presentation] Cancer-Associated Fibroblasts Promote Migration of Gastric Cancer Cells (2013)
  • Author(s): Y.Maeyama
  • Organizer: International Gastric Cancer Congress
  • Place of Presentation: Verona
  • Year and Date: 2013-06-22
• [Presentation] Analysis of gamma delta T cell and its accessory cells in cancer patients.
  • Author(s): 前山義博
  • Organizer: 日本分子生物学会
  • Place of Presentation: 神戸国際展示場
• [Presentation] がん関連線維芽細胞が胃がん細胞の移動に与える影響の解析
  • Author(s): 前山義博
  • Organizer: 日本癌学会
  • Place of Presentation: パシフィコ横浜