A new approach to the different biological function of PTH and PTHrP on osteoblastic cells
| Project/Area Number |
24659808
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
AMIZUKA Norio 北海道大学, 歯学研究科(研究院), 教授 (30242431)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 副甲状腺ホルモン / 副甲状腺ホルモン関連ペプチド / 骨芽細胞 / 前骨芽細胞 / 骨リモデリング / 細胞・組織 / PTH / PTHrP / 歯学 / 細胞組織 / PTH/PTHrP受容体 |
|---|
| Research Abstract |
It is well known that intermittent administration of PTH (parathyroid hormone) shows anabolic effects in bone, while continuous injection of PTH results in catabolic effects. When human PTH(1-34) was administered into mice with high frequency, actively-proliferating preosteoblasts, abundant osteoclasts and many mature osteoblasts forming bone matrices were observed, representing high bone turnover. However, when PTH(1-34) was administered with low frequency, preosteoblasts was not so proliferated, with less forming osteoclasts, and mature osteoblasts formed more bone. Meanwhile, the fetuses continuously overexpressing PTHrP (PTH-related peptide) showed a large numbers of preosteoblasts and bone marrow stromal cells without accompanying accelerated osteoclast formation, and a few mature osteoblasts formed bone matrix. Thus, PTH and PTHrP appear to differently show predominant effects to preosteoblastic and osteoblastic activities, despite their binding the common receptor.
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Report
(3 results)
Research Products
(26 results)
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[Journal Article] Sclerostin is differently immunolocalized in metaphyseal trabecules and cortical bones of mouse tibiae2013
Author(s)
Hasegawa T., Amizuka N., Yamada T., Liu Z., Miyamoto Y., Yamamoto T., Sasaki M., Hongo H., Suzuki R., Freitas PHL., Yamamoto T., Oda K., Li M
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Journal Title
Biomed Res
Volume: 34(3)
Pages: 153-159
NAID
Related Report
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[Journal Article] Histochemical aspects for vascular invasion at the erosion zone of epiphyseal cartilage in MMP-9 deficient mice2013
Author(s)
Kojima T., Hasegawa T., Freitas PHL., Yamamoto T., Sasaki M., Horiuchi K., Hongo H., Yamada T., Sakagami N., Saito N., Yoshizawa M., Kobayashi T., Maeda T., Saito C., Amizuka N
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Journal Title
Biomedical Res
Volume: 34(3)
Pages: 119-128
Related Report
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[Journal Article] Sclerostin is differently immunolocalized in metaphyseal trabecules and cortical bones of mouse tibiae2013
Author(s)
Hasegawa T., Amizuka N., Yamada T., Liu Z., Miyamoto Y., Yamamoto T., Sasaki M., Hongo H., Suzuki R., Freitas PHL., Yamamoto T., Oda K., Li M.
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Journal Title
Biomedical Research
Volume: 34
Issue: 3
Pages: 153-159
DOI
NAID
ISSN
0388-6107, 1880-313X
Related Report
Peer Reviewed
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