| Project/Area Number |
24659809
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
SUGAWARA Shunji 東北大学, 歯学研究科(研究院), 教授 (10241639)
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| Co-Investigator(Kenkyū-buntansha) |
KUROISHI Toshinobu 東北大学, 大学院歯学研究科, 助教 (30400261)
ENDO Yasuo 東北大学, 大学院歯学研究科, 技術補佐員 (50005039)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 金属アレルギー / ヒト化マウス / ニッケル |
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| Research Abstract |
The aim of this study was to elucidate pathogenesis of metal allergy using humanized mice by reconstituting human immune system in the mice. We used genetically modified immunodeficient mice as recipients and tried to engraft human peripheral blood mononuclear cells in the mice. We also depleted macrophages in the mice to increase immunodeficiency. We observed very weak engraftment of human lymphocytes in the mice but are unable to induce metal allergy. As analysis of pathogenesis of metal allergy using humanized mice is still fascinating project to develop medical service for the next generation, we continue to realize this project.
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