Elucidation of new function of glycogen - The possibility as accelerating agent for odontogenesis and osteogenesis
| Project/Area Number |
24659810
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
IDA Hiroko 新潟大学, 医歯学系, 准教授 (60293213)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Mikako 新潟大学, 医歯学総合病院, 講師 (20361909)
NAKATOMI Mitsushiro 九州歯科大学, 歯学部, 講師 (10571771)
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| Co-Investigator(Renkei-kenkyūsha) |
OHSHIMA Hayato 新潟大学, 医歯学系, 教授 (70251824)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | グリコーゲン / 酵素合成 / 歯胚 / 骨形成促進剤 / 歯胚形成 / グリコーゲン代謝 |
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| Outline of Final Research Achievements |
Glycogen is a storage form of glucose within mammalian cells and plays a major role in energy metabolism. Temporary glycogen storage has been observed in the cell differentiation stage during organ development, and understanding the glycogen metabolism that underlies various cell dynamics is essential for developing strategies for organ regeneration. Here, we investigated glycogen metabolism in murine tooth development. We demonstrated that glycogen metabolism is an essential pathway for dental cell differentiation. Next, we evaluated the effect of enzymatically synthesized glycogen (ESG) on osteogenesis as well as odontogenesis using in vitro and in vivo experimental model of mice. As results, ESG stimulated the cell growth and differentiation of dental cells and accelerated the growth of tooth explants in vitro. In conclusion, ESG could be a useful stimulant for osteogenesis and odontogenesis.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Bcl11b transcription factor plays a role in the maintenance of the ameloblast-progenitors in mouse adult maxillary incisors.2013
Author(s)
Katsuragi Y, Anraku J, Nakatomi M, Ida-Yonemochi H, Obata M, Mishima Y, Sakuraba Y, Gondo Y, Kodama Y, Nishikawa A, Takagi R, Ohshima H, Kominami R.
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Journal Title
Mechanism and Development
Volume: 130
Issue: 9-10
Pages: 482-492
DOI
Related Report
Peer Reviewed
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