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Elucidation of new function of glycogen - The possibility as accelerating agent for odontogenesis and osteogenesis

Research Project

Project/Area Number 24659810
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Morphological basic dentistry
Research InstitutionNiigata University

Principal Investigator

IDA Hiroko  新潟大学, 医歯学系, 准教授 (60293213)

Co-Investigator(Kenkyū-buntansha) TANAKA Mikako  新潟大学, 医歯学総合病院, 講師 (20361909)
NAKATOMI Mitsushiro  九州歯科大学, 歯学部, 講師 (10571771)
Co-Investigator(Renkei-kenkyūsha) OHSHIMA Hayato  新潟大学, 医歯学系, 教授 (70251824)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsグリコーゲン / 酵素合成 / 歯胚 / 骨形成促進剤 / 歯胚形成 / グリコーゲン代謝
Outline of Final Research Achievements

Glycogen is a storage form of glucose within mammalian cells and plays a major role in energy metabolism. Temporary glycogen storage has been observed in the cell differentiation stage during organ development, and understanding the glycogen metabolism that underlies various cell dynamics is essential for developing strategies for organ regeneration. Here, we investigated glycogen metabolism in murine tooth development. We demonstrated that glycogen metabolism is an essential pathway for dental cell differentiation. Next, we evaluated the effect of enzymatically synthesized glycogen (ESG) on osteogenesis as well as odontogenesis using in vitro and in vivo experimental model of mice. As results, ESG stimulated the cell growth and differentiation of dental cells and accelerated the growth of tooth explants in vitro. In conclusion, ESG could be a useful stimulant for osteogenesis and odontogenesis.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (20 results)

All 2015 2014 2013 2012 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (13 results) (of which Invited: 8 results)

  • [Journal Article] The effects of enzymatically synthesized glycogen on the pulpal healing process of teeth with intentionally delayed replantation in mice.2015

    • Author(s)
      Quispe-Salcedo A, Ida-Yonemochi H, Ohshima H
    • Journal Title

      Journal of Oral Biosciences

      Volume: 57 Pages: 124-130

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Establishment of in vitro culture system for evaluating dentin-pulp complex regeneration with special reference to the differentiation capacity of BrdU label-retaining dental pulp cells.2014

    • Author(s)
      Ida-Yonemochi H, Nakatomi M, Ohshima H
    • Journal Title

      Histochem Cell Biol

      Volume: 141 Issue: 3 Pages: 23-33

    • DOI

      10.1007/s00418-014-1200-7

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lymphoid Enhancer-binding Factor 1 Expression Precedes Dentin Sialophosphoprotein Expression during Rat Odontoblast Differentiation and Regeneration2013

    • Author(s)
      Nakatomi M, Ida-Yonemochi H, Ohshima H
    • Journal Title

      J Endod

      Volume: 39(5) Issue: 5 Pages: 612-618

    • DOI

      10.1016/j.joen.2012.12.016

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Use of a triple antibiotic solution affects the healing process of intentionally delayed replanted teeth in mice.2013

    • Author(s)
      Quispe-Salcedo A, Ida-Yonemochi H, Ohshima H
    • Journal Title

      J Oral Biosci

      Volume: 55 Pages: 91-100

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reciprocal expressions between α-dystroglycan and integrin β1, perlecan receptors, in the murine enamel organ development.2013

    • Author(s)
      Ida-Yonemochi H, Harada H, Ohshima H, Saku T
    • Journal Title

      Gene Expr Patterns

      Volume: 13 Issue: 8 Pages: 293-302

    • DOI

      10.1016/j.gep.2013.05.004

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bcl11b transcription factor plays a role in the maintenance of the ameloblast-progenitors in mouse adult maxillary incisors.2013

    • Author(s)
      Katsuragi Y, Anraku J, Nakatomi M, Ida-Yonemochi H, Obata M, Mishima Y, Sakuraba Y, Gondo Y, Kodama Y, Nishikawa A, Takagi R, Ohshima H, Kominami R.
    • Journal Title

      Mechanism and Development

      Volume: 130 Issue: 9-10 Pages: 482-492

    • DOI

      10.1016/j.mod.2013.05.002

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of perlecan, a basement membrane-type heparan sulfate proteoglycan, in enamel organ morphogenesis.2013

    • Author(s)
      Ida-Yonemochi H
    • Journal Title

      J Oral Biosci

      Volume: 55 Issue: 1 Pages: 23-28

    • DOI

      10.1016/j.job.2012.12.004

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] エナメル質形成を制御する糖代謝の新規メカニズム2015

    • Author(s)
      依田浩子
    • Organizer
      第120回日本解剖学会総会・全国学術集会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 歯の形態形成を制御する糖代謝機構2014

    • Author(s)
      依田浩子
    • Organizer
      第56回歯科基礎医学会学術大会・総会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Glycogen-shunt plays an important role in the relationship between cell differentiation and energy metabolism in organogenesis.2014

    • Author(s)
      Ida-Yonemochi H, Ohshima H, Harada H
    • Organizer
      EMBL Symposia
    • Place of Presentation
      EMBL Advanced Training Centre (Heidelberg, Germany)
    • Year and Date
      2014-08-27 – 2014-08-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 歯の形態形成を制御する糖代謝機構2014

    • Author(s)
      依田浩子
    • Organizer
      第38回峠の会(形態学セミナー)
    • Place of Presentation
      ホテルニューあけぼの(新発田市)
    • Year and Date
      2014-08-01 – 2014-08-02
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Biological effects of enzymatically synthesized glycogen on osteogenesis and Odontogenesis.2013

    • Author(s)
      Ida-Yonemochi H, Takata H, Ohshima H
    • Organizer
      2013 Tripartite Conference on Tooth and Bone
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] AKTシグナルがグリコーゲン代謝を促進しエナメル芽細胞分化を誘導する2013

    • Author(s)
      依田浩子,大島勇人,原田英光
    • Organizer
      第55回歯科基礎医学会学術大会・総会
    • Place of Presentation
      岡山市
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 歯科における再生医療研究の現状と展望2013

    • Author(s)
      依田浩子
    • Organizer
      第78回日本泌尿器科学学会東部総会
    • Place of Presentation
      新潟
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] The role of glycogen metabolism during murine salivary gland development.2013

    • Author(s)
      Hiroko Ida-Yonemochi
    • Organizer
      International Symposium Frontier Meeting, Seoul/Jeonju 2013 Development, Evolution, Taxonomy, and Genetics of Tooth Structure “Tooth Voyage, Up To Date”
    • Place of Presentation
      韓国、全州
    • Related Report
      2012 Research-status Report
  • [Presentation] The application of antimicrobials or glycogen accelerates the pulpal regeneration of replanted molars in mice.2013

    • Author(s)
      Angela Quispe-Salcedo, Hiroko Ida-Yonemochi, Hayato Ohshima
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      高松市
    • Related Report
      2012 Research-status Report
  • [Presentation] 酵素合成グリコーゲンによる骨形成促進作用メカニズムの解明2013

    • Author(s)
      依田浩子,中川英蔵,高田洋樹,監物新一,大島勇人
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      高松市
    • Related Report
      2012 Research-status Report
  • [Presentation] マウス唾液腺分化過程におけるグリコーゲン代 謝の役割2012

    • Author(s)
      依田浩子,中川英蔵,大島勇人
    • Organizer
      第54回歯科基礎医学会学術大会・総会
    • Place of Presentation
      郡山市
    • Related Report
      2012 Research-status Report
  • [Presentation] 酵素合成グリコーゲンの歯科再生医療への応用-新たな骨・歯胚形成促 進剤の開発を目指して-

    • Author(s)
      依田浩子
    • Organizer
      平成25年度第1回新潟大学東京事務所Evening Seminar & Communication Salon
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 歯胚構築における細胞外マトリックス・プロテオグリカンの動的機能

    • Author(s)
      依田浩子
    • Organizer
      第118回日本解剖学会総会・全国学術集会研究集会・懇話会
    • Place of Presentation
      高松市
    • Related Report
      2012 Research-status Report
    • Invited

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Published: 2013-05-31   Modified: 2019-07-29  

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