| Project/Area Number |
24659815
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAZA Haruyoshi 九州大学, 大学院歯学研究院, 講師 (30336151)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 乳歯幹細胞 / 造血機能 / 再生医療 / エリスロポイエチン / 骨髄ニッチ / エリスロポエチン |
|---|
| Research Abstract |
Erythropoietin (EPO) Receptor was expressed on stem cells from human exfoliated deciduous teeth (SHED). EPO-stimutated SHED unregulated Stat5 phospholiration. EPO-stimulated SHED were capable of increasing the formation of hematopietic niches compared to non-stimulated SHED when SHED were subcutanously transplanted with hydroxyapatite carriers into immunocompromised mice. In the increase hematopoietic niche, hematopoietic cells were found by immunofluorescent and flow cytometric analyses. Taken together, these data suggested that EPO is able to induce the capacity of hematopoiesis through SHED.
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