| Project/Area Number |
24659821
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中尾 龍馬 国立感染症研究所, 細菌第一部 (10370959)
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| Co-Investigator(Renkei-kenkyūsha) |
古川 壮一 日本大学, 生物資源科学部 (40339289)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | アミロイド / S. mutans / バイオフィルム / 遺伝子 / コンゴーレッド / 異常蛋白質 / SMU482 / SMU574 / S. gordonii / 病原性 / S, gordonii / コンゴ―レッド / 異常タンパク質 |
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| Research Abstract |
Amyloid is an insoluble fiber protein involving one specific structure. It was clealy that this amyloid was associated with the biofilm formation in gram positive bacteria.Streptococcus mutans is possessing the amyloid implicated in the biofilm formation.This study showed a posssibility that SMU482 and SMU574 associated with amyloid formation in S. mutans genes. SMU482 related with the biofilm formation but SMU574 did not related with that. Therefore, it was clearly that the amyloid formation is not necessarily concerned with biofilm formation.
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