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Role of oral bacteria on hepatitis

Research Project

Project/Area Number 24659823
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Functional basic dentistry
Research InstitutionOsaka University

Principal Investigator

WADA Koichiro  大阪大学, 歯学研究科(研究院), 准教授 (90263467)

Co-Investigator(Kenkyū-buntansha) NAKAJIMA Atsushi  横浜市立大学, 附属病院, 教授 (30326037)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords肝炎 / 口腔細菌 / LPS / NASH / 患者 / マウス / 脂肪蓄積 / レプチン / ヒト
Research Abstract

We investigated the role of oral bacteria-related substances on the development of nonalcoholic steatohepatitis (NASH). We found that P. gingivalis-related substances such as lipopolysaccharide (LPS) induced the pathogenesis of NASH on mice under high-fat diet condition. We found the potential mechanisms about the high-fat diet-induced and LPS-stimulated NASH on mice like that leptin-mediated hypersensitivity against LPS was involved in the mechanism. These findings are very important for the prevention of NASH, and we reported such findings to many high-level journals such as "Cell Metabolism".

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (21 results)

All 2014 2013 2012

All Journal Article (13 results) (of which Peer Reviewed: 13 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] Oral choline tolerance test as a novel noninvasive method for predicting nonalcoholic steatohepatitis.2014

    • Author(s)
      Imajo K, Yoneda M, Fujita K, Kessoku T, Tomeno W, Ogawa Y, Shinohara Y, Sekino Y, Mawatari H, Nozaki Y, Kirikoshi H, Taguri M, Toshima G, Takahashi J, Saito S, Wada K, Nakajima A.
    • Journal Title

      Journal of Gastroenterology

      Volume: 49 Issue: 2 Pages: 295-304

    • DOI

      10.1007/s00535-013-0776-3

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Microbiota and nonalcoholic steatohepatitis.2014

    • Author(s)
      Imajo K, Yoneda M, Ogawa Y, Wada K, Nakajima A.
    • Journal Title

      Seminars in Immunopathology

      Volume: 36 Issue: 1 Pages: 115-132

    • DOI

      10.1007/s00281-013-0404-6

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of fatty acid binding protein 4 is involved in the cell growth of oral squamous cell carcinoma2014

    • Author(s)
      Lee D, Wada K, Taniguchi Y, Al-Shareef H, Masuda T, Usami Y, Aikawa T, Okura M, Kamisaki Y, Kogo M
    • Journal Title

      Oncology Reports

      Volume: 31 Issue: 3 Pages: 1116-20

    • DOI

      10.3892/or.2014.2975

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Soluble CD14 levels reflect liver inflammation in patients with nonalcoholic steatohepatitis.2013

    • Author(s)
      Ogawa Y, Imajo K, Yoneda M, Kessoku T, Tomeno W, Shinohara Y, Kato S, Mawatari H, Nozaki Y, Fujita K, Kirikoshi H, Maeda S, Saito S, Wada K, Nakajima A.
    • Journal Title

      PLoS One

      Volume: 8(6) Issue: 6 Pages: 65211-65211

    • DOI

      10.1371/journal.pone.0065211

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rodent models of nonalcoholic Fatty liver disease/nonalcoholic steatohepatitis.2013

    • Author(s)
      Imajo K, Yoneda M, Kessoku T, Ogawa Y, Maeda S, Sumida Y, Hyogo H, Eguchi Y, Wada K, Nakajima A.
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 14 Issue: 11 Pages: 21833-21857

    • DOI

      10.3390/ijms141121833

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Critical role of leukotriene B4 receptor signaling in mouse 3T3-L1 preadipocyte differentiation2013

    • Author(s)
      Hirata K, Wada K, Murata Y, Nakajima A, Yamashiro T, Kamisaki Y
    • Journal Title

      Lipids in Health and Disease

      Volume: 12 Issue: 1 Pages: 122-122

    • DOI

      10.1186/1476-511x-12-122

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plasma free choline is a novel non-invasive biomarker for early-stage non-alcoholic steatohepatitis : A multi-center validation study2012

    • Author(s)
      Imajo K, Fujita K, Yoneda M, Shinohara Y, Suzuki K, Mawatari H, Takahashi J, Nozaki Y, Sumida Y, Kirikoshi H, Saito S, Nakamuta M, Matsuhashi N, Wada K, Nakajima A
    • Journal Title

      Hepatology Research

      Volume: 42 Issue: 8 Pages: 757-766

    • DOI

      10.1111/j.1872-034x.2012.00976.x

    • NAID

      10031144294

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of leukotriene B_4 receptor signaling in human preadipocyte differentiation.2012

    • Author(s)
      Hirata K, Katayama K, Nakajima A, Takada K, Kamisaki Y, Wada K
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 429(3-4) Issue: 3-4 Pages: 197-203

    • DOI

      10.1016/j.bbrc.2012.10.110

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differential expression of aquaporin 5 and aquaporin 3 in squamous cell carcinoma and adenoid cystic carcinoma.2012

    • Author(s)
      Ishimoto S, Wada K, Usami Y, Tanaka N, Aikawa T, Okura M, Nakajima A, Kogo M, Kamisaki Y
    • Journal Title

      Int J Oncol

      Volume: 41 Pages: 67-75

    • DOI

      10.3892/ijo.2012.1445

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Peroxisome proliferator-activated receptor gamma exacerbates Concanavalin A-induced liver injury via suppressing the translocation of NF-kB into the nucleus2012

    • Author(s)
      Ogawa Y, Yoneda M, Tomeno W, Imajo K, Shinohara Y, Fujita K, Shibata W, Kirikoshi H, Saito S, Wada K, Maeda S, Nakajima A
    • Journal Title

      PPAR Research

      Volume: 2012 Pages: 940384-940384

    • DOI

      10.1155/2012/940384

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hyperresponsivity to low-dose endotoxin during progression to nonalcoholic steatohepatitis is regulated by leptin-mediated signaling2012

    • Author(s)
      Imajo K, Fujita K, Yoneda M, Nozaki Y, Ogawa Y, Shinohara Y, Kato S, Mawatari H, Shibata W, Kitani H, Ikejima K, Kirikoshi H, Nakajima N, Saito S, Maeyama S, Watanabe S, Wada K, Nakajima A
    • Journal Title

      Cell Metab

      Volume: 16(1) Issue: 1 Pages: 44-54

    • DOI

      10.1016/j.cmet.2012.05.012

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hyperresponsivity to low-dose endotoxin during progression to nonalcoholic steatohepatitis is regulated by leptin-mediated signaling.2012

    • Author(s)
      Imajo K, Fujita K, Yoneda M, Nozaki Y, Ogawa Y, Shinohara Y, Kato S, Mawatari H, Shibata W, Kitani H, Ikejima K, Kirikoshi H, Nakajima N, Saito S, Maeyama S, Watanabe S, Wada K, Nakajima A
    • Journal Title

      Cell Metabolism

      Volume: 16 Pages: 44-54

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Plasma free choline is a novel non-invasive biomarker for early-stage non-alcoholic steatohepatitis: A multi-center validation study2012

    • Author(s)
      Imajo K, Fujita K, Yoneda M, Shinohara Y, Suzuki K, Mawatari H, Takahashi J, Nozaki Y, Sumida Y, Kirikoshi H, Saito S, Nakamuta M, Matsuhashi N, Wada K, Nakajima A
    • Journal Title

      Hepatology Research

      Volume: 42 Pages: 757-766

    • NAID

      10031144294

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] マイクロRNAによる脂肪細胞分化の制御2014

    • Author(s)
      村田由香, 和田孝一郎, 平田佳永, 山城隆
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] Resveratrol improves pathogenesis of nonalcoholic steatohepatitis through inhibition of endotoxin-induced liver damage2013

    • Author(s)
      Kessoku T, Imajo K, Tomeno W, Ogawa Y, Mawatari H, Yoneda M, Kirikoshi H, Saito S, Wada K, Nakajima A
    • Organizer
      The 64th Annual Meeting of the American Association for the Study of Liver Diseases : The Liver Meeting 2013
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Small dense low-density lipoprotein as a useful biomarker for predicting arteriosclerotic diseases in nonalcoholic steatohepatitis2013

    • Author(s)
      Imajo K, Yoneda M, Kessoku T, Tomeno W, Ogawa Y, Mawatari H, Kirikoshi H, Sumida Y, Hyogo H, Eguchi Y, Wada K, Nakajima A
    • Organizer
      The 64th Annual Meeting of the American Association for the Study of Liver Diseases : The Liver Meeting 2013
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Resveratrol improves pathogenesis of nonalcoholic steatohepatitis through inhibition of endotoxin-induced liver damage.2013

    • Author(s)
      Kessoku, T; Imajo K, Tomeno W, Ogawa Y, Mawatari H, Yoneda M, Kirikoshi H, Saito S, Wada K, Nakajima A.
    • Organizer
      The 64th Annual Meeting of the American Association for the Study of Liver Diseases.
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] ここまでわかった口腔内細菌による全身疾患 : 最新の研究と臨床知見 :非アルコール性脂肪肝炎発症のリスクファクターとしての口腔内細菌2012

    • Author(s)
      和田孝一郎
    • Organizer
      長崎市歯科医師会招待教育講演
    • Place of Presentation
      長﨑
    • Year and Date
      2012-09-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Association between estrogen receptor alpha gene polymorphism and development of nonalcoholic fatty liver disease (NAFLD)2012

    • Author(s)
      Imajo K, Hotta K, Yoneda M, Kessoku T, Ogawa Y, Shinohara Y, Suzuki K, Shibata W, Kirikoshi H, Saito S, Wada K, Nakajima A
    • Organizer
      The 63rd Annual Meeting of the American Association for the Study of Liver Diseases : The Liver Meeting 2012
    • Place of Presentation
      Boston, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] ここまでわかった口腔内細菌による全身疾患:最新の研究と臨床知見: 非アルコール性脂肪肝炎発症のリスクファクターとしての口腔内細菌2012

    • Author(s)
      和田孝一郎.
    • Organizer
      長崎市歯科医師会招待 教育講演
    • Place of Presentation
      長崎
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] 「非アルコール性脂肪肝炎におけるレプチンと腸内細菌の役割─レプチンによるエンドトキシン感受性の制御を中心として」.糖尿病学2013(門脇孝編)2013

    • Author(s)
      中島淳,今城健人,米田正人,和田孝一郎
    • Publisher
      医学書出版診断と治療社,東京
    • Related Report
      2013 Final Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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