| Project/Area Number |
24659823
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
WADA Koichiro 大阪大学, 歯学研究科(研究院), 准教授 (90263467)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAJIMA Atsushi 横浜市立大学, 附属病院, 教授 (30326037)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 肝炎 / 口腔細菌 / LPS / NASH / 患者 / マウス / 脂肪蓄積 / レプチン / ヒト |
|---|
| Research Abstract |
We investigated the role of oral bacteria-related substances on the development of nonalcoholic steatohepatitis (NASH). We found that P. gingivalis-related substances such as lipopolysaccharide (LPS) induced the pathogenesis of NASH on mice under high-fat diet condition. We found the potential mechanisms about the high-fat diet-induced and LPS-stimulated NASH on mice like that leptin-mediated hypersensitivity against LPS was involved in the mechanism. These findings are very important for the prevention of NASH, and we reported such findings to many high-level journals such as "Cell Metabolism".
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