The study of the molecular bases on differences in salt taste sensitivity, palatability and saliva component induced by low or high sodium diet
Project/Area Number |
24659828
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Single-year Grants |
Research Field |
Functional basic dentistry
|
Research Institution | Kyushu University |
Principal Investigator |
|
Project Period (FY) |
2012-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 口腔生理 / 味覚 / ENaC / アンジオテンシン / アルドステロン / 国際情報交換 |
Research Abstract |
Salty taste is a crucial sense for detecting essential minerals, especially sodium ions in the environment and influences sodium intake. Angiotensin II is a key hormone that regulates sodium homeostasis. This study demonstrated that Angiotensin II suppresses amiloride-sensitivity of the mouse gustatory and behavioral responses to NaCl via its receptor AT1 expressed in taste cells. Interestingly, significant increases of taste nerve responses to sweeteners were also observed after the Angiotensin II administration, without effects on the responses to sour, bitter and umami tastants. These results suggest that the regulatory mechanisms by Angiotensin II on the salt and sweet taste sensitivities may exist in peripheral taste organs, contribute to salt and calorie intake, and play important roles in sodium and glucose homeostasis.
|
Report
(3 results)
Research Products
(60 results)
-
-
-
-
-
-
-
-
[Presentation] ホルモンによる塩味および甘味感受性調節2014
Author(s)
重村憲徳, 吉田竜介, 安松啓子, 大栗弾宏, 岩田周介, 高井信吾, 上瀧将史, 仁木麻由, 實松敬介, 二ノ宮裕三
Organizer
第91回日本生理学会大会
Place of Presentation
鹿児島(審査有, 口頭)
Related Report
-
-
-
-
-
[Presentation] ホルモンによる味覚修飾と摂食調節2013
Author(s)
重村憲徳, 吉田竜介, 安松啓子, 大栗弾宏, 岩田周介, 高井信吾, 上瀧将史, 仁木麻由, 實松敬介, 二ノ宮裕三
Organizer
日本味と匂学会第47回大会
Place of Presentation
仙台(審査有, 口頭)
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Taste perception and food intake2013
Author(s)
Shigemura N, Yoshida R, Yasumatsu K, Ohkuri T, Sanematsu K, Jyotaki M, Niki M, Ninomiya Y
Organizer
The 86th Annual Meeting of The Japanese Pharmacological Society
Place of Presentation
Fukuoka, Japan
Related Report
Invited
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-