| Project/Area Number |
24659828
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 口腔生理 / 味覚 / ENaC / アンジオテンシン / アルドステロン / 国際情報交換 |
|---|
| Research Abstract |
Salty taste is a crucial sense for detecting essential minerals, especially sodium ions in the environment and influences sodium intake. Angiotensin II is a key hormone that regulates sodium homeostasis. This study demonstrated that Angiotensin II suppresses amiloride-sensitivity of the mouse gustatory and behavioral responses to NaCl via its receptor AT1 expressed in taste cells. Interestingly, significant increases of taste nerve responses to sweeteners were also observed after the Angiotensin II administration, without effects on the responses to sour, bitter and umami tastants. These results suggest that the regulatory mechanisms by Angiotensin II on the salt and sweet taste sensitivities may exist in peripheral taste organs, contribute to salt and calorie intake, and play important roles in sodium and glucose homeostasis.
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